Volume-11 ~ Issue-12 ~ December-2018

Abstract: N-(1-hydroxy propyl) indole was prepared by the reaction of indole with trimethylenechlorohydrin in presence of powdered potassium hydroxide in the solvent medium of DMF stirring at first at room temperature for 4h and then at 400c for 12h. N-(propyl acetate) indole was prepared by the reaction of N-(1-dydroxy propyl) indole with acetic anhydride and pyridine in the water bath for 2h. N-(propylacetate)-3- formylindole was synthesized by the reaction of N-(propyl acetate) indole with POCl3 and DMF mixture stirring at first at 00c for 1h and then at 1000c for 2h. 2-[N-(propylacetate) indolyl]-6- nitro benzothiazole was synthesized by the treatment of N-(propylacetate) -3- formylindole with 2-amino-5-nitro thiophenol in presence of Baker's yeast in the solvent medum of DCM at room temperature for 30h..

Key words: N-(1-hydroxy propyl) indole, N-(propyl acetate)-3-formyl indole, 2-[N-(1-hydroxy propyl) indolyl]-6-nitro benzothiazole, 2-[N-(propyl acrylate) indolyl]-6-nitro benzothiazole, co-polymerization

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Abstract: The reported tetranuclear zinc(II) complex [Zn4(HL)4](NO3)4.2H2O(H2L=1,5-bis(1-(pyridin-2-yl)ethylidene)carbonohydrazide) has been prepared by mixing a methanol solution of Zinc nitrate salt and a methanol solution of H2L in 1:1 molar ratio. The suitablemonocrystalsafforded wereanalysedby X-ray diffraction. The title compound crystallizes in the tetragonal space group I41/a with the following unit cell parameters: a = 14.0254(2) Å, b = 14.0254(2) Å, c = 35.7967(8) Å, α = 94.610(4)°, V = 7041.6(3) Å3, Z = 4, R1 = 0.048 and wR2 = 0.136. The structuresare[2x2] square grids of tetramers units in whichthe metal ions are joined in pairs by the oxygen atom of the..........

Keywords: Schiff base,crystal, complex, grid, luminescence,octahedral.

[1]. J. Ferrando-Soria, J. Vallejo, M. Castellano, J. Martínez-Lillo, E. Pardo, J. Cano, I. Castro, F. Lloret, R. Ruiz-García, M. Julve, Molecular magnetism, quo vadis? A historical perspective from a coordination chemist viewpoint, Coord. Chem. Rev., 2017, 339, 17–103.
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Abstract:The simple and sensitive spectrophotometric method for the determination of Olanzapine reacts with 1ml of DDQ (2, 3 –dichloro -5, 6-dicylano-1, 4-benzoquinone) by charge –transfer complex method. In this method the drug Olanzapine as n-electron donors with acceptor 2, 3 dichloro-5, 6- dicyano 1,4- benzoquinone (DDQ) to form reddish pink color charge-transfer complexes. This reaction is instantaneous and quantitative. The drug maximum absorbance at 450 nm and Beer's law limit was obeyed at 30-150 μg/ml. The optical characteristics of the proposed method such as molar absorptivity, sandell's sensitivity, slope and intercept were 5.16x103 L.mole-1 cm-1 , 0.00161 μg.cm-2 ,0.0050 and -0.005 the correlation coefficient is 0.9999 for Olanzapine respectively. The developed method was found to be simple, specific, robust, accurate and precise for the determination of Olanzapine.

Keywords: Olanzpine, chloroform, methanol, DDQ and UV-Spectrophotometric method

[1]. N. Rajendra Prasad and K. Basavaiah. J of Anal Chemistry, 65, 2010, 482.
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Abstract:In view of the current trend in ICT evolution with incessant usage of web and other online services, copying, sharing, storing and transmitting information is by far done through digital media. It is no surprise that countless methods of protecting such data have evolved, but the greatest disadvantage in digital text transmission is the fact that inestimable digital copies of the data/file can be made and is liable of tainted. This leads to the global problem of copyright protection, copy protection and content authentication. This work critically examines information hiding techniques of text document and their consequences. Various watermarking system properties and..........

Keywords: Watermarking, Steganography, Attack, Text document image, ICT, etc.

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Abstract:A series of novel coumarin isoxazole (3a-3f) and (5a-5f) have been synthesized in good yield starting from 4-formylcoumarins. These newly synthesized coumarin-isoxazole conjugates are mimic structur of valdicoxib which is an anti-inflammatory agent. All the synthesized compounds were screened for their antibacterial and anti-inflammatory activity. The antibacterial activity results exhibited high selectivity against gram positive bacterial strains than gram negative bacterial strains. Interestingly, phenylsulphonamide substituted molecules 5a-5f are more promising against bacterial strains. Further, the anti-inflammatory study showed inhibition of matrix metalloprotiens (MMPs). Particularly, compounds are quite promising with significant inhibition properties against MMP-2 and MMP-9. All the compounds have been characterized by IR, 1HNMR, 13C NMR and mass spectral data.

Keywords: Anti-inflammatory, coumarin-oxime, coumarin-isoxazole, phenylsulphonamide

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Abstract: Groundnut shells, a low-cost agricultural waste material were used without any physical or chemical modification as an alternative and cheap adsorbent for the removal of Cr (VI) ion from aqueous solution. The aqueous solutions containing different concentrations of Cr (VI) were treated with fixed doses of groundnut shells powder for an equilibrium time of 90 min. The determination of Chromium (VI) concentration in the sample solutionswas carried out using UV-Vis spectrophotometer by the diphenylcarbazide indicator method. The equilibrium isotherm studies showed...........

Keywords: Adsorption, adsorbent, groundnut shell, isotherm, chromium

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Abstract: Schiff base ligand [(N1E,N2E)-N1,N2-bis(4-methoxybenzylidene)benzene-1,2-diamine](L) was synthesis through a condensation reaction of benzene-1,2-diamine and 4-Methoxy benzaldehyde in acidic conditions .The synthesis ligand has described with different(C.H.N,1H&13C-N.M.R,, UV-VisandFT-IR) techniques. Mixed complexesof some metal ions [Hg(II), Mn(II), Ni(II),Cu(II) and Co(II)] were prepared by the reaction of Schiff base(L)and 1,10-Phenanthronline with the divalent metal ions in basic medium. The synthesis mixed complexes were characterized with different (atomic absorption, UV-Vis, FT-IR, micro elemental analysis, molar conductance...........

Keywords: antibacterial

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Abstract: Heavy metals are environmentally stable, toxic and tend to accumulate in human beings causing chronic adverse effects on human health. This study was aimed to determine the level of six heavy metal contents in water samples. These water samples were taken from Lake Afdera, lower and upper Dobi (Elidar District) groundwater sites of Afar regional state, Ethiopia. For this study, eight water samples were collected from each three locations. Samples were mixed and one representative sample was taken from each site. All the samples were analyzed for six heavy metals namely; Pb, Cu, Mn, Ni, Zn and Cd, using standard procedures and inductively coupled plasma optical emission spectrometer (ICP-OES).The heavy metals concentrations in the Lake water and groundwater samples of Lake Afdera...........

Keywords: Lake water, Ground water, Heavy metals, ICP-OES.

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Abstract: Oxazole derivatives of ferrocene have been synthesized. Acetyl ferrocene was reacted with substituted benzaldehyde to get substituted chalcones of ferrocene. These were further reacted with hydroxylamine hydrochloride to get oxazole derivatives. Synthesized compounds were characterized by FT-IR, and H1-NMR spectroscopy, these were further evaluated for their Antibacterial activity.

Keywords: Acetyl ferrocene, spectral data and anti-bacterial activity

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Abstract: Drug–polymer conjugation is a modest and competent approach to synthesizing new, effective, and potent antimicrobial agents to counter the problem of microbial resistance. In the present study, a PEGylated thiazoles were synthesized by using the PEGylation process. A series of PEGylated amino thiazoles were evaluated for antibacterial activity against the gram negative , gram positive bacterial strains i.e.,Escherichia coli & Staphylococcus aureus respectively, using cup plate method. Among all PEGylated thiazoles, many derivatives exhibited significant microbial activity against bacterial strains. The newly synthesized compounds were characterized by elemental analysis, IR and 1HNMR, 13CMR and Mass spectral data.

Keywords: PEGylation, thiazoles, antibacterial activity

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Abstract: In the present study various nucleoside derivatives were synthesized by condensing differently substituted [1,3,4] Oxadiazole-2(3H) one with β-D-1,2,3,4,6-penta-O-acetylglucopyranosyl followed by deacetylation. Structure of obtained compounds has been established by using tools like IR, 1HNMR, and elemental analysis. The compounds have been evaluated for their antifungal behavior against fungi such as Aspergillus flavus, Aspergillus niger and Fusarium oxysporum. The disk diffusion methodology was applied for the values of minimum inhibitory concentration using well known antifungal agent fluconazole as reference standard in cases of all the studies done.

Keywords: Antifungal Agent, Nucleosides, Oxadiazole, Fluconazole

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