Abstract: Cerebral ischemic stroke is a life threatening neurological disorder leads to mortality and long term disability in survival patients. Atherosclerosis is a common cause of ischemic strokes which inturn predisposes thromboembolism and than triggers thrombotic strokes or transient ischemic attacks. The atherogenic nature of homocysteine plays a vital role in the development of cardiac or cerebral ischemic strokes. The purpose of this case - control study was to corelate homocysteine in cerebral ischemic stroke patients.
Keywords: stroke, homocysteine, ischemia, thrombosis
[1] Hatano S. Experience from a multicentre stroke register: a preliminary report. Bull World Health Organ 1976; 54:541–553.
[2] Dalal PM. Strokes in young and elderly: risk factors and strategies for stroke prevention. J Assoc Phys India 1997;. 45:125-31.
[3] Itrat A, Ahmed B, Khan M, Muhammad M, Risk factor profiles of South Asians with cerebrovascular disease Int J Stroke. 2011 Aug;6(4):346-8.10.1111/j.1747-4949.2011.00622.x
[4] Qian Jia, MD, Liping Liu, MD, PhD, Yongjun Wang, Risk Factors and Prevention of Stroke in the Chinese Population: Journal of Stroke and Cerebrovascular Diseases Volume 20, Issue 5, September–October 2011, Pages 395–400 [5] Baidarbhi Chakraborty, Gaurav Vishnoi, Binita Goswami, Lipoprotein(a), Ferritin, and Albumin in Acute Phase Reaction Predicts Severity and Mortality of Acute Ischemic Stroke in North Indian Patients: Journal of Stroke and Cerebrovascular Diseases 2012.10.013,10.1016
[6] Bertsch T, Mielke O, Höly S, Zimmer W, Casarin W, Homocysteine in cerebrovascular disease: an independent risk factor for subcortical vascular encephalopathy:Clin Chem Lab Med. 2001 Aug;39(8):721- 4
[7] Abraham R, John MJ, Calton R, Dhanoa J. Raised serum homocysteine levels in patients of coronary artery disease and the effect of vitamin b12 and folate on its concentration. Indian Journal Of Clinical Biochemistry 2006;21(1):95-100.
[8] Elizabeth A. Varga, MS; Amy C. Sturm, MS; Caron P. Misita, PharmD;Stephan Moll, MD Homocysteine and MTHFR Mutations Relation to Thrombosis and Coronary Artery Disease Circulation. 2005; 111: e289-e293
[9] Hanke, Graeme J.; Eikelboom, John W: Homocysteine and stroke: Current Opinion in Neurology:February 2001 - Volume 14 - Issue 1 - pp 95-102
[10] Chambers JC, McGregor A, Jean-Marie J, Obeid OA, Kooner JS. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Circulation.1999;99:1156-1160