Volume-10 ~ Issue-6 ~ June-2017

Abstract: The kinetics of oxidation of 2-phenyl-benzothiazole (BzlH), 2-(4-methoxyphenyl) benzothiazole (OMeBzlH), 2-(4-nitrophenyl)-benzothiazole (NO2BzlH) by chloramine-T; (CAT) in presence of HClO4 has been investigated at 296 K. Under similar experimental conditions, the oxidation reactions follow identical kinetics for all the three benzothiazoles with first order dependence each on [CAT]0 and [substrate]0 and inverse fractional order dependence on [H+]. Solvent composition shows negative effect indicating the involvement of negative ion-dipolar molecule in the rate determining............

Keywords: Activation parameters, dielectric constant, halide effect, Order,reaction mechanism

[1]. S Gupta, N Ajmera,N Gautam, R Sharma and D Gauatam. Novel synthesis and biological activity study of pyrimido [2,1-b] benzothiazoles. Ind J Chem,48B,2009,853-858.
[2]. R.M Kumbhare and V N Ingle, Synthesis of novel benzothiozole and benzisoxazole functionalized unsymmetrical alkanes and study of their antimicrobial activity,Ind J Chem,48B,2009, 996-1000.
[3]. Y.Murthi andD. Pathak, Synthesis and Antimicrobial screening of SubstitutedMercaptobenzothiazoles. J Pharm Res,7(3),2008,153-155.
[4]. B.Rajeeva,N. Srinivasulu andS. Shantakumar, Synthesis and Antimicrobial activity of some new 2-substituted benzothiazolederivatives. E-Journal of Chemistry, 6(3), 2009, 775-779
[5]. M. Maharan,S. William , F. Ramzy andA. Sembel, Synthesis and in vitro Evaluation of new benzothiazolederivaties as schistosomicidal agents,Molecules 12, 2007, 622-633.

Abstract: Recently bio-based polymers have received great importance due to their eco-friendly properties towards environment. As a substitute of conventional reinforcing synthetic polymer, bio-based polymers were from renewable resources like cardanol, i.e., the meta-substituted phenolic compound the chief product of CNSL. A number of IPNs have been synthesized by condensing di-azotised-4-amino benzoic acid and 3-amino benzoic acid cardanol dye with polyurethane of soybean oil. The IPNs produced have been characterized by FTIR, TGA, DSC (Differential scanning calorimetry). Elemental analysis and WAXRD studies. Thermal stability of IPNs has been studied by both TGA and DSC which provides heat capacity and kinetic parameters (order of reaction and activation energy) by Freeman Anderson method of the sample.

Keywords: Cardanol based dye, thermal stability, crystallinity, activation energy, interpenetrating polymer network.

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Abstract: The aim of this research work is to develop a suitable HPLC method for the quantitative determination of process impurity (4-Bromophenyl) {Pyridine-2-yl} Acetonitrile as this compound is organic cyano compound hence it is necessary to quantify at ppm level presence of Brompheniramine Maleate Active Pharmaceutical Ingredient. Hence the HPLC method was developed on Instrument Waters 717 plus Auto Sampler, Waters 2487 Dual _ Absorbance Detector, Waters 2695 Separation Module, Waters 996 PDA Detector with Empower 2 Software on HPLC column Varian C18, 150 x 4.6 mm, 5μ at a flow rate of 1.5 mL/min. The limit of detection and the limit of quantitation for the impurity were established. Validation of the new developed HPLC method was carried out as per requirements of ICH guideline and the data shows that the proposed method is specific, linear, accurate..................

Keywords: High-performance liquid chromatography (HPLC), Process impurity; (4-Bromophenyl){Pyridine-2-yl} Acetonitrile (BPPA), HPLC Column, Brompheniramine Maleate, Threshold of Toxicological Concern (TTC).

[1]. ICH, Validation of Analytical Procedure: Methodology (Q2B), International Conference on Harmonization, Geneva 1996.
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[3]. International Conference on harmonization of technical requirements for registration of pharmaceuticals for human use. Validation of analytical procedures: text and methodology Q2 (R1). Current Step 4 Version, 2005.
[4]. A. Marin, E. Garcia, A. Garcia, C. Barbas, Validation of a HPLC quantification of acetaminophen, phanylephrine and chlorpheniramine in pharmaceutical formulation: capsules and sachets, Journal of Pharmaceutical and Biomedical Analysis, 29, 2002, 701-714.
[5]. N.G. Rathod, M.V. Lokhande, Characterisation and Identification of Process Related Impurity in Amodiaquine Hydrochloride by Using Some Analytical Techniques: A Review, American Journal of Advanced Drug Delivery, 3(5), 2015, 264-284.

Abstract: Bismuth (III) thiolates/dithiolates have been synthesized by electrochemical reactions of ethanethiol, 2-propanethiol, 2-methylpropane-2-thiol, Butanethiol, 1-pentanethiol, , Ethane- 1, 2-dithiol and Butane-1, 4-dithiol at sacrificial bismuth anode and inert platinum cathode using tetrabutylammonium chloride as supporting electrolyte. The coordination compounds of these thiolates/dithiolates with 1, 10-phenanthroline and 2, 2'-bipyridyl have also been synthesized electrochemically. The solid products that separated in the anode compartment have been isolated and characterized by elemental analysis and infrared spectral studies. Current efficiencies of these reactions are quite high.................

Keywords: H-type cell, electrochemical synthesis, Bismuth (III) thiolates/dithiolates, current efficiencies, sacrificial electrode.

[1] Baljit Singh and Harpreet Kaur, Direct electrochemical synthesis of bismuth (III) phenoxides and their coordination compounds, E- Journal of Chemistry, 9(1), 2012, 381-388.
[2] J.S. Banait, Baljit Singh and Harpreet Kaur, J. Indian. Chem. Soc, 56, 2008, 156.
[3] Baljit Singh and Harpreet Kaur, Electrochemical reactions at sacrificial electrodes. Part-XXIII: Direct electrochemical synthesis of bismuth (III) alkoxides, J. Indian. Chem. Soc, 85, 2008, 849-851.
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Abstract: The series of Co (II), Ni (II) and Cu(II) metal complexes quinolin-8-yl (1,3-benzoxazol-2-ylsulfanyl)acetate (BZ) have been synthesized. All the complexes thoroughly characterized by different physico-chemical and spectroscopic techniques (UV-Vis, IR, NMR and ESI-Mass). The powder XRD indicates the crystalline state and morphology of Ni (II) and Cu (II) metal complexes, the thermal stability of the metal complexes as been performed. In the current study, the synthesized compounds were evaluated for their antioxidant activity by using DPPH assay, Cu (II) metal complex exhibited higher antioxidant activity almost close to the standard BHT.................

Keywords: Benzoxazole, metal complex, XRD, Antioxidant, molecular docking

[1] M. Prudhomme, J. Guyot, G. Jeminet, Semi-synthesis of A23187 (calcimycin) analogs. IV. Cation carrier properties in mitochondria of analogs with modified benzoxazole rings Antimicrobial activity, Journal of Antibiotics. 39, (1986), 934-7.
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Abstract: An on-line preconcentration procedure for the determination of heavy metal ions using Flow-injection approach with flame atomic absorption spectroscopy is developed significantly in recent years. This review focuses on chelating resins based on Amberlite XAD resins which have been used in Flow Injection analysis since 1996.The factors like detection limit, enrichment factor and sample throughput are reported. Chelates immobilized on Amberlite XAD matrices and the metal ions separated and determined together with references are given in the review.

Keywords: Flow-Injection, FAAS, Amberlite XAD resins

[1] A. Efendioglu, M. Yagan, B. Bat; Bi(III)4-methylpiperidinedithiocarbamate coprecipitation procedure for separation–pre-concentration of trace metal ions in water samples by flame atomic absorption spectrometric determination; J.Hazard. Mater. 149 (2007) 160–165.
[2] M.R. Jamali, Y. Assadi, R.R. Kozani, F. Shemirani; Homogeneous Liquid-Liquid Extraction Method For Selective Separation And Preconcentration Of Trace Amounts Of Palladium; E-Journal Of Chemistry 6(4) (2009) 1077-1084.
[3] M. Soylak, Y.E. Unsal, N. Kizil, A. Aydin; Utilization of membrane filtration for preconcentration and determination of Cu(II) and Pb(II) in food, water and geological samples by atomic absorption Spectrometry; Food and Chemical Toxicology 48 (2010) 517–521.
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Abstract: The proximate composition and antibacterial activity of Crinum zeylanicum bulb was evaluated with the aim of understanding the rationale usage by herbal traditional practitioners on trouble skin and bone setting/healing. Aqueous, ethanol and n-hexane extracts were tested on Staphylococcus aureus, Streptococcus pneumoniae, Bacillus cereus, Escherichia coli, Salmonella typhi and Shigella dysenteriae using the agar well diffusion technique and zones of inhibition in diameter................

Keywords: Antibacterial activity, bone setting/healing, Crinum zeylanicum bulb, proximate composition, herbal medicine.

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Abstract: Inhibition of soybean (Glycine max) urease by heavy metal ions has been investigated with a view to developing a method for the indirect determination the heavy metals. Urease activity was assayed as a function of metal concentration in the presence of Cd2+, Cr3+, As3+, Cu2+, Pb2+ and Zn2+. Our results revealed concentration dependent inhibition of urease activity within the range of 0.001 – 10 mg/L for Cu2+, As3+, Cr3+ and Cd2+ and 0.1 – 10 mg/L for Zn2+ and Pb2+. The inhibitory strengths of the metals as evaluated from their IC50 values showed the following ranking.................

Keywords: Enzyme, Heavy metals, Inhibition soybean, urease

[1] N. Gan, X.Yang, D. Xie, Y. Wu and W. Wen, A disposable organophosphorus pesticides enzyme biosensor based on magnetic composite nano-particles modified screen printed carbon electrode, Sensors, 10, 2010, 625-638.
[2] Y. Braham, H. Barhoumi and A. Maaref, Urease capacitive biosensors using functionalized magnetic nanoparticles for atrazine pesticide detection in environmental samples, Anal. Methods, 5, 2013, 4898.
[3] K. Loh, Y. H. Lee, A. Musa, A. Salmah and I. Zamri, Use of Fe3O4 nanoparticles for enhancement of biosensor response to the herbicide 2,4-dichlorophenoxyacetic acid, Sensors, 8, 2008, 5775-5791.
[4] S.R Budnikov, O.O Soldatkin , A.L Kukla, I.I Khomenko, S.V Dzyadevych and O.P Soldatkin , Investigation and optimization of reactivation of urease biosensor for heavy metals inhibition analysis, Biotechnologia acta, 8, (6), 2015, 16-21.
[5] S.A Ahmad, M.I.E. Halmi, M.H Wasoh, W.L.W. Johari, M.Y Shukor, and M.A Syed, The development of a specific inhibitive enzyme assay for the heavy metal lead, JEBAT, 1(1), 2013, 9-13...

Abstract: Natural clay drags attention because of their wide application, ample availability, lower cost and ease of modification. Acid treatment of raw clay is easiest way to activate clay. Acid activation improves their bleaching action and also enhances their efficiency as adsorbent. In this paper, study is focused on different aspects of acid activation. Changes in structure, chemical and mineralogical composition and surface morphology have been studied using advanced techniques like FTIR, EDAX, XRD and SEM, respectively.................

Keywords: Clay, montmorillonite, acid-activation, structural modification.

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Abstract: DFT implemented in ADF.2012.01 was applied to study the structures of three macrocyclic paramagnetic hexa coordinate complexes: [L3M]2+ {M=V(II), Ni(II)}, and [L3Cr]3+ (L=2,2-bipyridine) by four spectral techniques. After their pre-optimization, the software was run by using Single Point, LDA, Default, Relativity, Spin Orbit, ZORA, Unrestricted, None, Collinear, Nosym using TZP or TZ2P Basis sets in ESR/EPR/EFG/ZFS Program to obtain ESR parameters: g11, g22, g33, giso, a11, a22, a33, At...............

Keywords: Chemical Shift, Total NMR Shielding Tensor, Nuclear Quadrupole Coupling Constant, Effective Spin Hamiltonian, Asymmetric Coefficient

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