Volume-10 ~ Issue-8 ~ August-2017

Abstract: A series of novel 3-(4-(5-amino-1,3,4-oxadiazol-2-yl)phenyl)-1-arylprop-2-en-1-one (chalcones) were obtained by treatment of 4-formyl benzoic acid with different substituted acetophenone followed by reaction with semicarbazide hydrochloride in presence of phosphorous oxychloride. The structures of isolated compounds were confirmed by 1H NMR, IR, LC-MS and elemental analyses. All the derivatives of chalcones were tested for their antibacterial activities against gram negative bacteria Escherichia coli and gram positive bacteria Bacillus subtilis, , Micrococcus luteus, Staphylococcus aureus..

Key words: antibacterial activities, chalcones, oxadiazoles

[1]. S.S Turkar, A.H. Rodge , G.D. Hatnapure et al, Synthesis and anti-bacterial, anti-fungal activity of some novel chalcone derivatives,
Journal of Chemical and Pharmaceutical Research, 2(5), 2010, 348-355.
[2]. M.M.H. Bhuiyan, M.I. Hossain, Mahmud M.M et al, Microwave-assisted Efficient Synthesis of Chalcones as Probes for
Antimicrobial Activities, Chemistry Journal, 01(01), 2011, 21-28.
[3]. Noviany, H. Osman, S. Mohamad et al, Synthesis and biological evaluation of 2′-hydroxy-retro-chalcone derivatives as
antituberculosis agent, Journal of Chemical and Pharmaceutical Research, 8(8), 2016, 468-474.
[4]. T.L.B. Ventura, S.D. Calixto, B. A. Abrahim-Vieira et al, Antimycobacterial and Anti-Inflammatory Activities of Substituted
Chalcones Focusing on an Anti-Tuberculosis Dual Treatment Approach, Molecules, 20, 2015, 8072-8093.
[5]. G. Avila-Villarreal, O. Hernadez-Abreu, S. Hidalgo-Figueroa et al, Antihypertensive and vasorelaxant effects of
dihydrospinochalcone-A isolated from Lonchocarpus xuul Lundellby NO production: computational and ex vivo approaches,
Phytomedicine, 20, 2013, 1241-1246.

Abstract: Natural products appears as an alternative to the use of chemical catalysts for water purification and treating the effluents from textile and dying industries. The Photo-catalytic activities of leaf extracts of S. nigrum, M. koenigii H. cannabinus L and M.arvensisw were studied using methylene blue and congo red dyes. The reactions were done both in presence and absence of light. in the aqueous solution under UV-lamp irradiation as a light source. On comparing the results of dye degradation of methylene blue and congo red with four different plant extracts Mentha arvensis showed maximum percent degradation and minimum degraded percent was observed in Hibiscus cannabinus..

Key words: Congo red, methylene blue, photocatalytic, S. nigrum, M. koenigii, H. cannabinus L , M.arvensis

[1] H. Hassena, Photocatalytic Degradation of Methylene Blue by Using Al2O3/Fe2O3 NanoComposite under Visible Light, Modern Chemistry and Applications, 4(1),2016.
[2] S. Miraj, Solanum nigrum: A review study with anti-cancer and antitumor perspective, Der Pharma Chemica, 8(17),2016,62-68.
[3] F. O. Atanu, U. G. Ebiloma and E. I. Ajayi, A review of the pharmacological aspects of Solanum nigrum Linn, Biotechnology and Molecular Biology Review, 6(1), 2011,001-007
[4] A Eltayeb Elsadig, S Al-Ansari Alia, G Roddick James, Changes in the steroidal alkaloid solasodine during development of Solanum nigrum and Solanum incanum. Phytochemistry, 46(3),1997, 489-494.
[5] Vandana Jain, Munira Momin, Kirti Laddha, Murraya Koenigii: An Updated Review International Journal Of Ayurvedic And Herbal Medicine , 2(4), 2012, 607-627..

Abstract: In the thematic issue we synthesized transition metal complexes with N / S donor ligands. The structures of the obtained complexes were characterized by FT-IR, NMR, elemental analysis, ESR spectral studies, conductometric and magnetic moment measurements. The magnetic moments and electronic spectral studies suggests that the complex has distorted octahedral geometry with unpaired electron lying in dx2 – y2 orbital giving 2B1g as the ground state. The synthesized metal complexes were successfully investigated for biological activities namely antibacterial, antifungal, DNA binding and cleavage activity etc. In an effort towards the development of metallodrugs as chemotherapeutic............

Key words: Antioxidants, Azoles, Copper, Flavonoid Content, Reducing Power.

[1]. M Ozaki, Y. Adachi, Y. Iwahori, and N. Ishii, Application of fuzzy theory to writer recognition of Chinese characters, International Journal of Modelling and Simulation, 18(2), 1998, 112-116.
[2]. B.H.M. Mruthyunjayaswamy, G. Y. Nagesh, M. Ramesh, B. Priyanka and B. Heena, Synthesis, characterization and antioxidant activity of Schiff base ligand andits metal complexes containing thiazole moiety, Der Pharma Chemica, 7(10), 2015, 556-562.
[3]. K. H. Kumar Naik, B. Ashok and N. Nagaraja, .Biologically active N/O/S donor ligands: Synthesis, characterization and biological activity with Metal chelates, International Journal of Chemical and Pharmaceutical Sciences, 4 (2), 2013, 110-116.
[4]. J. Joseph, G. Boomadevi Janaki, Synthesis, Structural Characterization And Biological Studies Of Copper Complexes With 2-Aminobenzothiazole Derivatives, Journal of Material Environment Science, 5 (3), (2014), 693-704.
[5]. E. Akila, M. Usharani and R. Rajavel, Metal (II) Complexes Of Bioinorganic and Medicinal Relevance: Antibacterial, Antioxidant And DNA Cleavage Studies Of Tetradentate Complexes Involving O, N-Donor Environment Of 3, 3′-Dihydroxybenzidine-Based Schiff Bases, International Journal of Pharmacy and Pharmaceutical Sciences, 5(2), 2013, 573-581.

Abstract: Four benzimidazole derivatives namely bis(2-benzimidazolyl-methyl)amine (L1), bis(2 benzimidazolyl-phenyl)amine (L2), bis(2-benzimidazolyl-methyl-6-sulfonate)amine (L3) and bis(2-benzimidazolyl-phenyl-6-sulfonate)amine (L4) were synthesized through condensation reaction of 1, 2-diaminocompounds and dicarboxylic acids. The benzimidazole derivatives and their corresponding oxovanadium (IV), Copper (II) and Zinc (II) complexes were characterized using 1H and 13C NMR, UV-Visible and Infra-red spectroscopies, metal analysis, conductivity...........

Key words: Anti-microbial agents, Benzimidazole, Metal complexes, Syntheses,

[1]. Ansari, K. F. and Lal, C, Synthesis and evaluation of some new benzimidazole derivatives as potential antimicrobial agents. European journal of medicinal chemistry, 44(5), 2009, 2294-2299.
[2]. Kazimierczuk, Z., Upcroft, J. A., Upcroft, P., Górska, A., Starosciak, B. and Laudy, A,.Synthesis, antiprotozoal and antibacterial activity of nitro-and halogeno-substituted benzimidazole derivatives.ActaBiochimicaPolonica-English Edition-, 49(1), 2002, 185-196.
[3]. Grocer, H., Kus, C., Boykin, D. W., Yildiz, S. and Altanlar, N, Synthesis and Anti-fungal Properties of Some Benzimidazole Derivatives. Bioorganic Medicinal Chemistry10, 2002, 2589-2596.
[4]. Tuncbilek, M., Kiper T. and Altanlar, N, Synthesis and in vitro anti-microbial activity of some novel substituted benzimidazole derivatives having potent activity against MRSA. European Journal of Medicinal Chemistry,44, 2009, 1024–1033.
[5]. H. Marijana, S. Kristina, K. Sandra, et al., Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles, Eur. J. Med. Chem., 46, 2011, 2274–2279. ..

Abstract: Piper guineenseis a West African species of Piper known by the Igbos in the South-eastern Nigeria as Uziza. The spice obtained from its dried fruit is ambiguously known as Guinea pepper or West African black pepper. The leaves of this plant have been shown to be useful as spices and in traditional medicine. This study presents the proximate analysis as well as the qualitative and quantitative screening of the phytochemical constituents extracted from the leaves of this indigenous plant by solvent extraction using 95% ethanol. The results of the proximate analysis showed that on dry weight basis, the moisture content is 11.04% (22.08 mg/g), ash content 14.14% (28.28 mg/g), crude protein..............

Key words: Piper guineense, Guinea pepper, West African pepper, uziza, phytochemicals, proximate analysis

[1]. Ara I., Bukhari, N.A., Solaiman, D. and Bakir, M.A (2012). Antimicrobial effect of local medicinal plant extracts in the Kingdom of Saudi Arabia and search for their metabolites by gas chromatography-mass spectrometric (GC-MS) analysis. Journal of Medicinal Plants Research6(45), 5688-5694.
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Abstract: Chemoselective tetrazole ring opening of pyrazolotetrazolopyrimidines 2, obtained from 4- chloropyrazolopyrimidines 1, by reduction with Sodium borohydride under solid-liquid and liquid-liquid phase transfer catalysis has been carried out to form pyrazolopyrimidineamines 3. A comparative study of conventional as well as phase transfer catalysis for synthesis of pyrazolopyrimidineamines 3 has also been reported. One pot synthesis of 3 directly form 1 under liquid-liquid PTC has also been conducted with insitu generation of 2.

Key words: Chemiselective reaction, Pyrazolopyrimidines, PTC, 18-C-6, Aliquat

[1]. N. S. Habib, S. M. Rida, E. A. M. Badawey, and H. T. Y. Fahmy; Condensed Thiazoles, II: Synthesis of 7-Substituted Thiazolo[4,5-d]pyrimidines as Possible Anti-HIV, Anticancer, and Antimicrobial Agents, Monatshefte fiir Chemie 127, 1209-1214, 1996
[2]. C. J. Shishoo and S. K. Jain, Synthesis of some novel azido/tetrazolothienopyrimidines and their reduction to 2,4-diaminothieno[2,3-d]pyrimidines, J Heterocycl. Chem., 29, 883, 1992
[3]. C. G. Dave, R. D. Shah, Synthesis of 7H-Tetrazolopyrrolopyrimidines and their reductive ring cleavage to 4-aminopyrrolopyrimidines: J. Heterocycl. Chem., 31, 1800, 1999

Abstract: The study of the volumetric behavior of Cetrizine HClas electrolytes in solution provides information useful to elucidate ion–ion, ion–solvent, and solvent–solvent interactions. Apparent molar volumes (Φv), and excess viscosity forCetrizine HCl in aqueous system have been determined from density (ρ) and viscosity (η) measurements at four different temperatures using the ANTON PAAR densitometer and Mansing Survismeter respectively. Various concentrations ofaqueous solutionsof Cetrizine HCl ranging from 0.02 to 0.1 M were prepared. The apparent molar volumes were calculated from the density data. In addition adiabatic compressibility and acoustic impedance is also determined. The concentration dependence of the apparent and partial molar volumes can be used to study ion–ion interactions, whereas the partial molar volumes at infinite dilution provide information on ion–solvent interactions.

Key words: Cetrizine HCl, density, excess viscosity, acoustic impedance.

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