Volume-17 ~ Issue-7 ~ July 2024

Abstract: Bivalirudin is used as anticoagulant in patients with coronary artery disease undergoing percutaneous coronary intervention. Also it is safe and cost effective as compared to other anticoagulants which are in use. Bivalirudin is a peptide having 20 amino acids. Related impurities formed during the manufacturing process determine quality of the peptide drugs. These impurities may cause toxicity or change the desired efficacy. ICH guidelines established by regulatory authorities have provided identification threshold for related impurities to ensure purity of.......

Keywords: Bivalirudin, Mass, NMR Spectroscopy, HPLC, Amino acid sequencing, Anticoagulant

[1] Jing Li, Sanbao Chen, Sicong Ma, Mingque Yang, Zizhao Qi, Kun Na, Miaohan Qiu, Yi Li, And Yaling Han, (2022), Safety And Efficacy Of Bivalirudin Versus Unfractionated Heparin Monotherapy In Patients With Cad And Dm Undergoing Pci: A Retrospective Observational Study, Cardiovascular Therapeutics, Volume 2022, Article Id 5352087, 10 Pages
[2] Kostromina M.A., Tukhovskaya E.A., Shaykhutdinova E.R., Slashcheva G.A., Ismailova A.M., Palikov V.A., Palikova Y.A., Dyachenko I.A., Kravchenko I.N., Sadovnikova E.S., (2021), Screening Of The Promising Direct Thrombin Inhibitors From Haematophagous Organisms. Part I: Recombinant Analogues And Their Antithrombotic Activity In Vitro, Biomedicines 2022, 10, 11
[3] Alessandra Basso, (2019), Development Of A Novel Combined Iex-Rp Chromatographic Process For The Purification Of Bivalirudin, Chromatography Today, August / September 2019
[4] Nilini Ranbaduge, Ying Qing Yu, (2018), Synthetic Peptide Characterization And Impurity Profiling Using A Compliance-Ready Lc-Hrms Workflow, Waters, 720006367, August 2018
[5] Hua Yang, Stephan M. Koza, William J. Warren, Weibin Chen, (2018), Synthetic Peptide Impurity Analysis On Waters Reversed-Phase Columns, Waters, 720006244, April 2018

Abstract: The global demand for clean and sustainable energy sources has led to the exploration of hydrogen (H₂) as a promising alternative, due to its high energy content and zero-emission characteristics. This review highlights the potential of carbon dots (CDs) in photocatalytic hydrogen production, emphasizing their exceptional optical and electronic properties, including broad-spectrum light absorption, upconverted photoluminescence, and superior electron transfer capabilities. CDs, a novel class of carbon nanomaterials, offer advantages such as low cost, low.......

Key Word: Carbon dots; Photocatalytic H2 Generation; Carbon dots based Hybrid/Composites

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Abstract: A new series of transition metal complexes have been synthesized by conventional as well as microwave technique from ligand, HL E-N'-(2-hydroxy-4-methoxybenzylidene)-5-methyl-2H-pyrazole-3-carbohydrazide (3) in methanol. The Key intermediate schiff base ligand were prepared by allowing condensation of 2-hydroxy-4-methoxybenzaldehyde (1) with 5-methyl-1H-pyrazole-3-carbohydrazide (2) under microwave irradiation using bio based greener solvent system ethyl lactate: water. The authenticity of these ligands and their Fe(II), Zn(II), Cu(II), Co(II) and Ni(II) complexes were confirmed on the basis of spectroscopic technique such as Mass, IR, 1H NMR, UV spectroscopy and elemental analyses. The thermal stability of metal complexes was also studied by TGA..

Key Word: Pyrazole schiff-base ligand, Metal Complexes, Ethyl lactate Microwave irradiation

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Https://Doi.Org/10.1016/0065-2571(77)90012-7
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[5] Huang Zx, May Pm, Quinlan Km, Metal Binding By Pharmaceuticals. Part 2. Interactions Of Ca(Ii), Cu(Ii), Fe(Ii), Mg(Ii), Mn(Ii) And Zn(Ii) With The Intracellular Hydrolysis Products Of The Antitumour Agent Icrf 159 And Its Inactive Homologue Icrf 192. Agents And Actions. 1982; 12:536–542. Https://Doi.Org/10.1007/Bf01965940

Abstract: Struvite (MgNH4PO4.6H2O) is a phosphate mineral that has recently become a prudent venture for many researchers due to its nutritional value to plants in the field of agriculture. The cost of production of this mineral heavily relies on the cost of the magnesium source used. In this study, hot spring water was investigated as a potentially cheaper natural source of magnesium ions while sewage wastewater was used as a source of phosphate and ammonium ions for the struvite synthesis. The synthesized struvite composite was then characterized........

Key Word: Characterization, Hot spring water, Struvite, Synthesis, Wastewater

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