Series-1 (May – Jun.2024)May – Jun. 2024 Issue Statistics
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| Paper Type | : | Research Paper |
| Title | : | Unraveling The Molecular Landscape Of Diabetic Retinopathy : Pivotal Genes And Pathways |
| Country | : | India |
| Authors | : | Tamil Selvan T |
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: | 10.9790/ 264X-1003010107  |
Abstract: Diabetic Retinopathy (DR) is one of the major microvascular complications in diabetes mellitus and is a leading cause of vision impairment worldwide. The condition usually arise due to the chronic exposure of retinal blood capillaries to high glucose, leading to dysruption in the tight junctions of retinal capillaries, increased vascular permeability, chronic inflammation, apoptosis, and neovascularization causing vitreous heamorrhage and tractional retinal detachment followed by irreversible vision loss. Proliferative diabetic retinopathy is the advanced stage of DR and is characterized by the formation of neovessels that are immature and leaky in nature....
Keywords: Diabetic retinopathy, Neovascularization, Tractional retinal detachment, Chronic inflammation, Antioxidant defense system, Angiogenesis
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| Paper Type | : | Research Paper |
| Title | : | Effect Of Semi-Organic Culture Media Based On Musa Paradisiaca L. Peels Crude Extract On Growth, Soluble Protein Content, General Pigments And Secondary Metabolites Quality Of Arthrospira Platensis. |
| Country | : | Cameroon |
| Authors | : | Baleng Fabrice || Mutlen Melvin || Zango Paul || Fokom Raymond Tomedi Eyango Minette |
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: | 10.9790/ 264X-1003010820 |
Abstract: Background:The cyanobacterium Arthrospira platensis is a food source of high nutritional quality thanks to the diversity and richness of its constituents. However, its production in a synthetic medium is very costly given the excessively high mineral element requirements of this micro-alga. The aim of this study was to evaluate the effect of Musa paradisiaca peels crude extract on the growth, soluble protein content, general pigments and secondary metabolites quality of Arthrospira platensis....
Keywords: Arthrospira platensis, Musa paradisiaca, growth, soluble proteins, general pigments, secondary metabolites
[1].
Abd El-Baky, Hanna H., El Baz, Farouk K., El –Baroty, Gamal S., 2009. Production Of Phenolic Compounds From Spirulina Maxima Microalgae And Its Protective Effects In Vitro Toward Hepatotoxicity Model. Electronic Journal Of Environmental, Agricultural & Food Chemestry. Snn:1579-4377,Vol 8, Issue 12, P1099.
[2].
Aoac.(2000). Analysis Of The Association Of Official Analytical Chemists. (Ed. William, H.), 17ed., Gaithersburg, Md, Usa, Pp.141-144.[3].
Arvouet-Grand A, Vennat B, Pourrat A, Legret P. Standardisation D'un Extrait De Propolis Et Identification Des Principaux Constituants. Journal De Pharmacie De Belgique. 1994;49:462-468.
[4].
Assemand, E., Camera, F., Kouame, F., Konan, V. And Kouame, L.P. (2012) Biochemical Characterization Of Plantain (Musa Paradisiaca) Variety 'Agnrin' Fruits In Côte D'ivoire And Sensory Evaluation Of Its Derivatives. Journal Of Applied Biosciences, 60: 4438-444.
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| Paper Type | : | Research Paper |
| Title | : | Anticancer Docking Study Of Selected Compound Of Clove |
| Country | : | Nigeria |
| Authors | : | Dawen D. E || C. A. Amienyo || O.B. Okechalu || Asogwa N.T |
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: | 10.9790/ 264X-1003012130 |
Abstract: This study was designed to identify the phytochemicals from ethanolic extract of Syzygiumaromaticum(clove) using Gas Chromatography–Mass Spectrometery (GC-MS) analysis against cancer. Various anticancer medications have been discovered due to advances in the health care industry though they have adverse side-effects. Anticancer drugs derived from natural sources have low side effects, making them good for cancer therapy. This study aimed....
Keywords: Syzygiumarmaticum, GC-MS, Molecular docking, anticancer
[1] Rebecca, L., Siegel, M. P. H., Kimberly, D., Miller, M. P. H., &Ahmedinjemal, D. V. M. (2018).Cancer Statistics. Ca: A Cancer Journal For Clinicians, 68(1), 7–30
[2] Ferlay, J., Colombet, M., Soerjomataram, I., Mathers, C., Parkin, D., Pineros, M., Znaor, A., & Bray, F. (2019).Estimating The Global Cancer Incidence And Mortality In 2018: Globocan Sources And Methods.International Journal Of Cancer, 144, 1941–1953
[3] Mullan, P. B., Quinn, J. E., & Harkin, D. P. (2006).The Role Of Brca1 In Transcriptional Regulation And Cell Cycle Control. Oncogene, 25, 5854–5863.
[4] Saravanan, R., Raja, K. Andshanthi, D. (2022). Gc – Ms Analysis, Molecular Docking And Pharmacokinetic Properties Of Phytocompounds From Solatiumtorvum Unripe Fruits And Its Effect On Breast Cancer Target Protein.
Applied Biochembiotechnol194(1): 529 – 555.
[5] Burga, L. N., Tung, N. M., &Troyan, S. L. (2009).Altered Proliferation And Diferentiation Properties Of Primary Mammary Epithelial Cells From Brca1 Mutation Carriers.Cancer Research, 69, 1273–1278.
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| Paper Type | : | Research Paper |
| Title | : | Effect Of Prolonged Administration Of Aqueous And Methanol Leaf Extracts Of Vitex Doniana And Bombax Buonopense On The Activities Of Liver Enzymes Of Albino Rats. |
| Country | : | |
| Authors | : | Nweke, Odinachi Lynda |
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: | 10.9790/ 264X-1003013141 |
Abstract: Samples of Vitex doniana and Bombax buonopense leaf were collected from Abakaliki metropolis. The edible portion were washed dried, ground into powdered and fed Albino rats for 21 days at different concentration ranging from 100, 200, 400 and 800mg/kg body weight of the Albino rats. Thereafter, the level of liver enzymes: AST, ALP, ALT and 5'-Nucleotidas were measured using standard procedures and histological analysis of the hepatic tissue was also conducted. From, the analysis the administration of the aqueous and methanol leaf extracts of....
Keywords: Vitex doniana, Bombax buonopense, Liver enzymes, Histological studies
[1]
Abdu K And Echeme J.O (2006). Phytochemical And Antimicrobial Screening Of The Ethanoic Extract Of Leaves Of Anogeissus Leiocarpus. Best 3:162-164.
[2]
Abdulrahman, F. I., Akan, J. C., Sodipo, O. A. And Onyeyili, P. A. (2010). Effect Of Aqueous Root-Bark Extract Of Vitex Doniana Sweet On Haematological Parameters In Rats. Journal Of American Science, 6(12):8-12.
[3]
Ansah, E., Oppong, E And Duwiejua, M. (2009). Toxicity Study On Alchornea Cardifolia; Journal Of Natural Health, 2 (1): 19-24.
[4]
Asase A. Oppong-Mensah G (2009). Traditional Antimalarial Phytotherapy Remedies In Herbal Markets In Southern Ghana. Journal Ethnopharmacol 126:492-499.
[5]
Beentje, H.J.,1994. Kenya Tress, Shrubs And Lianas. 1st Edition, National Museums Of Kenya, Kenya, Pp:1-722.
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| Paper Type | : | Research Paper |
| Title | : | Abatement Of Potassium Bromate Induced Hepatorenal Toxicity And Altered Biochemical Indices In Male Wistar Rats Using Ethanol Leaf Extract Of Irvingia Gabonensis |
| Country | : | Nigeria |
| Authors | : | Kalu, W.O. || Nwauche, K.T. || Ngozi Kalu Achi || David –Chukwu. N. || Nmeregini, G.K || Ighorodje-Monago, C.C. || Belonwu, D.C. |
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: | 10.9790/ 264X-1003014253 |
Abstract: The renal toxicity associated with potassium bromate (KBrO3) treatment in both animals and humans have been reported. Irvingia gabonensis a perennial plant belonging to the family Irvingiaceae is known to elicit beneficial health effects. However, the influence of Irvingia gabonensis on the renal and hepatotoxicity associated with KBrO3 induced nephrone toxicity is unavailable in the literature. The current study evaluated the effects of Irvingia gabonensis on the dysfunctional renal and liver status triggered by KBrO3 exposure in rats. Experimental animals were exposed to KBrO3 (50mg/kg), co-treated with Irvingia gabonensis (500 mg/kg) and (1000 mg /kg) for 14 days. Results revealed that Irvingia gabonensis treatment significantly assuaged KBrO3-mediated....
Keywords: Potassium Bromate, Irvingia gabonensis, Kidney, Histopathology, Oxidative stress, inflammatory stress.
[1]
Adamson, I., Okafor, C. And Abu-Bakare, A. (1990) A Supplement Of Dikanut (Irvingia Gabonesis) Improves Treatment Of Type Ii Diabetics. West African Journal Of Medicine, 9: 108-115.
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Adewole, S.O., Salako, A.A., Doherty, O.W., Naicker T. (2007). Effect Of Melatonin On Carbon Tetrachloride-Induced Kidney Injury In Wistar Rats. African Journal Of Biomedical Research, 10:153–164
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Ajonuma, L. C., Chang, L. N., Chow, P. H., Kung, L. S., Chang, A. N., Ho, L. S., Briton-Jones, C, Lok, I. H., Haines, C. J., Chan, H. C. (2005). Ultrastructural Characterization Of Whole Hydrosalpinx From Infertile Chinese Women. Cell Bio Int; 25: 849-856.
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Beutler E., Duron O. And Kelly M. B. (1963). Improved Method For Determination Of Blood Glutathione. Journal Of Laboratory And Clinical Medicine, 61: 882–888.
[5]
Cadenas, S, Barja, G. (1999). Resveratrol, Melatonin, Vitamine, And Pbn Protect Against Renal Oxidative Dna Damage Induced By Kidney Carcinogen Kbro3. Free Radical Biology And Medicine, 26:1531–1537.
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| Paper Type | : | Research Paper |
| Title | : | Evaluation Of Antibiotic Resistant Microorganisms From Selected Manured Farmlands In Parts Of Enugu State, Nigeria |
| Country | : | Nigeria |
| Authors | : | Edeh, Princess Amarachi || Tasie, Floretta Omebere || Mbah-Omeje Kelechi Nkechinyere |
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: | 10.9790/ 264X-1003015462 |
Abstract: Background: A rising concern in recent years has been the entry of resistance genes into the food system through the amendment of soils with manure from animals treated with antibiotics. This study examined the prevalence of antibiotic-resistant microorganisms (ARM) from selected manured farmlands. Materials and Methods: A total of 12 soil samples were collected randomly from farmlands (maize farm, yam farm, cassava farm and control soil) in 3 local governments (Enugu North, West and South) within Enugu State, Nigeria. Prior....
Keywords: Soil, Resistant microorganisms, PCR, Antibiotics. Antifungal drugs
[1]
Aleruchi, C., Eboatu, A. N., And Emenalom, O. O. (2019). "Antifungal Susceptibility Testing: Methods And Interpretation." Journal Of Medical Microbiology, 27(4): 213-230.
[2]
Amarakoon, I.D., Surac, S., Zvomuya, F., Cessna, A.J. And Larney, F.J. (2016). Dissipation Of Antimicrobials In A Seasonally Frozen Soil After Beef Cattle Manure Application. Journal Of Environmental Quality, 45: 1644–1651
[3]
Bhullar, K., Waglechner, N., Pawlowski, A., Koteva, K. And Banks, E.D. (2012). Antibiotic Resistance Is Prevalent In An Isolated Cave Microbiome. Plos One, 7: E349-353.
[4]
Binh, C.T.T., Heuer, H., Kaupenjohann, M. And Smalla, K. (2008). Piggery Manure Used For Soil Fertilization Is A Reservoir For Transferable Antibiotic Resistance Plasmids. Fems Microbiology Ecology, 66: 25–37.
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Chantziaras, I., F. Boyen, Callens, B. And Dewulf, J. (2014). "Correlation Between Veterinary Antimicrobial Use And Antimicrobial Resistance In Food-Producing Animals: A Report On Seven Countries". Journal Of Antimicrobial Chemotherapy, 69(3): 827-834.