Series-2 (May – Jun. 2025) May – Jun. 2025 Issue Statistics
- Citation
- Abstract
- Reference
- Full PDF
- Cover Paper
| Paper Type | : | Research Paper |
| Title | : | Molecular Markers of Cervical Cancer Stem Cells |
| Country | : | |
| Authors | : | HARIOM RAJPUT || JYOTI SHINDE |
 |
: | 10.9790/ 264X-1103020108  |
Abstract: Cervical cancer remains the leading cause of cancer-related mortality among women, despite the existence of screening and vaccination programs. While treatments such as surgery and chemotherapy can extend the lives of patients, they do not offer a permanent cure. Radical surgery is often required for advanced-stage cervical cancer, but this comes with the risk of impairing fertility and potential recurrence of the disease. Hence, there is a critical need to develop new......
Keywords: Cervical Cancer, Cancer Stem Cells, Cervical Cancer Stem Cells, Human Papillomavirus (HPV), Tumorigenesis, Radiation Resistance.
1.A.B. de Villemeur, C. Exbrayat, A. Garnier, R. Ancelle-Park, J.-P. Ferley, C. Jestin, Evaluation of a combined screening programme for breast, cervical and colorectal cancers in France, European journal of cancer prevention (2007) 26-35.
2.G. Mendoza‑Almanza, E. Ortíz‑Sánchez, L. Rocha‑Zavaleta, C. Rivas‑Santiago, E.Esparza‑Ibarra, J. Olmos, Cervical cancer stem cells and other leading factors associated with cervical cancer development, Oncology Letters 18(4) (2019) 3423-3432.
3.A.J. Minn, G.P. Gupta, P.M. Siegel, P.D. Bos, W. Shu, D.D. Giri, A. Viale, A.B. Olshen, W.L. Gerald, J. Massagué, Genes that mediate breast cancer metastasis to lung, Nature 436(7050) (2005) 518-524.
4.M. Maqbool, M.A. Dar, I. Gani, S.A. Mir, M. Khan, Herbal medicines as an alternative source of therapy: a review, World J Pharm Pharm Sci 3 (2019) 374-80.
5.J.M. Walboomers, M.V. Jacobs, M.M. Manos, F.X. Bosch, J.A. Kummer, K.V. Shah, P.J. Snijders, J. Peto, C.J. Meijer, N. Muñoz, Human papillomavirus is a necessary cause of invasive cervical cancer worldwide, The Journal of pathology 189(1) (1999) 12-19..
- Citation
- Abstract
- Reference
- Full PDF
| Paper Type | : | Research Paper |
| Title | : | Molecular Docking Insights into Cannabidiol's Antimicrobial Potential Against Resistant Bacteria |
| Country | : | Brazil |
| Authors | : | Leonardo Ferreira Oliveira || Alessandro Soares Fonseca de Matos || Nayara Gonçalves Pereira || Adriana Froes do Nascimento Souto || Agueda Maria de França Tavares || Franciane Gabrielle dos Santos || Ageu Emerson Braz do Carmo || Suze Adriane Fonseca || Joao Bosco de Souza Júnior || Lorena Bianca Chaves Barbosa || Sabrina Ferreira Simões do Nascimento || Meriane Gonçalves Resende || Ana Elisa Lelis de Oliveira || Maria Júlia Ribeiro Magalhães |
|
: | 10.9790/ 264X-1103020914 |
Abstract: Background: The global rise in antimicrobial resistance (AMR) has made traditional antibiotics increasingly ineffective. Cannabidiol (CBD), a compound from Cannabis sativa, has gained attention for its antimicrobial potential, particularly due to its unique mechanisms and effectiveness against resistant bacteria.
Materials and Methods: Researchers used molecular docking to study CBD's interaction with bacterial proteins from both Gram-positive and Gram-negative species. Proteins were selected from the Protein Data Bank, prepared using PyMOL, and docked with CBD using.......
Keywords: Cannabidiol, Docking, Resistance, Proteins.
[1].
Ji S, An F, Zhang T, Lou M, Guo J, Liu K, Zhu Y, Wu J, Wu R. Antimicrobial peptides: An alternative to traditional antibiotics. Eur J Med Chem. 2024;265:116072.
[2].
Sharma P, Kaur J, Sharma G, Kashyap P. Plant derived antimicrobial peptides: Mechanism of target, isolation techniques, sources and pharmaceutical applications. J Food Biochem. 2022;46(10):e14348.
[3].
Xuan J, Feng W, Wang J, Wang R, Zhang B, Bo L, Chen ZS, Yang H, Sun L. Antimicrobial peptides for combating drug-resistant bacterial infections. Drug Resist Updat. 2023;68:100954.
[4].
Periferakis A, Periferakis K, Badarau IA, Petran EM, Popa DC, Caruntu A, Costache RS, Scheau C, Caruntu C, Costache DO. Kaempferol: Antimicrobial Properties, Sources, Clinical, and Traditional Applications. Int J Mol Sci. 2022;23(23):15054.
[5].
Kesavan Pillai S, Hassan Kera N, Kleyi P, de Beer M, Magwaza M, Ray SS. Stability, biofunctional, and antimicrobial characteristics of cannabidiol isolate for the design of topical formulations. Soft Matter. 2024;20(10):2348-2360
- Citation
- Abstract
- Reference
- Full PDF
| Paper Type | : | Research Paper |
| Title | : | Biopython and Nextgeneration sequencing data analysis of Neuroblastoma derived PHOX2B peptide |
| Country | : | India |
| Authors | : | Mansi Jangir || Uma Kumari |
|
: | 10.9790/ 264X-1103021524 |
Abstract: This work is devoted to computational analysis of the Neuroblastoma-derived PHOX2B peptide bound to HLA-A24:02. PDB ID 7MJA. PHOX2B encodes a homeobox protein that plays a crucial role in the development of the autonomic nervous system. The focus of this study is on the HLA-A24:02 complex, which could be of importance in immune surveillance and targeted therapy. A comprehensive analysis has been performed regarding the structure of the peptide, its functional domains, and interaction with HLA-A24:02. Using Biopython for sequence.........
Keywords: Neuroblastoma, NGS, Peptide, PHOX2B, sequenceAnalysis, Mutation Detection, Biopython, Proteomics
[1]. Yarmarkovich M, Marshall QF, Warrington JM, et al. Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs [retracted in: Nature. 2023 Nov;623(7988):872. doi: 10.1038/s41586-023-06731-z]. Nature. 2021;599(7885):477-484. doi:10.1038/s41586-021-04061-6
[2]. Zafar A, Wang W, Liu G, et al. Molecular targeting therapies for neuroblastoma: Progress and challenges [published correction appears in Med Res Rev. 2022 Jan;42(1):641. doi: 10.1002/med.21843]. Med Res Rev. 2021;41(2):961-1021. doi:10.1002/med.21750
[3]. Aygun N. Biological and Genetic Features of Neuroblastoma and Their Clinical Importance. CurrPediatr Rev. 2018;14(2):73-90. doi:10.2174/1573396314666180129101627
[4]. Boeva V, Louis-Brennetot C, Peltier A, et al. Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries. Nat Genet. 2017;49(9):1408-1413. doi:10.1038/ng.3921
[5]. Peggion S, Najem S, Kolman JP, Reinshagen K, PagerolsRaluy L. Revisiting Neuroblastoma: Nrf2, NF-κB and Phox2B as a Promising Network in Neuroblastoma. Curr Issues Mol Biol. 2024;46(4):3193-3208. Published 2024 Apr 6. doi:10.3390/cimb46040200.