Volume-6 ~ Issue-2 ~Mar. – apr. 2020

Abstract: Diabetes mellitus (DM) is a metabolic disorder where by glucose cannot effectively get transported out of the blood. It is a chronic disease with a high prevalence and a growing concern in worldwide. There are two Types of diabetes, which are Type I and Type II. A longitudinal data analysis retrospective based study was conducted between 1 st September, 2012 to 30 th August 2015 in Debre Berhan referral hospital.The main objective of the study was to analysis of progression of Diabetes Mellitus patients using fasting blood sugar level count following insulin, metformin and to identify factors predicting the progression of diabetic infection using logistic regression. Methods: A total of 248.....

Key Words: Diabetics, Diabetes Mellitus, Clinical diagnosis of insulin, Referral Hospital, Logistic regression

Abstract: CAR T-cell remedy is a "precision medicine" treatment, which means remedy that is tailored to person sufferers. It also belongs to a brand new group of most cancers treatments known as immunotherapy. In CAR T Cell remedy, a person's T-cells which might be a number of the body's maximum essential immune cells are taken from their blood, and then infused into the man or woman's bloodstream. As of late, one of the most encouraging novel malignancy treatments has been the improvement of illusory antigen receptor CAR T cells. Their best model is focusing on the B cell lineage explicit surface antigen CD19, But CARs allow T-cells to locate and kill most cancers-carrying cells, that may otherwise be tough to perceive. Once within the bloodstream, CAR T-cells maintain to multiply, and this is why the treatment is every now and then called a "living drug."In one tisagenlecleucel.....

Key Words: T cell · Gene modification, chimeric antigen receptor, Cancer, immunotherapy

Abstract: Objectives: Attention-deficit hyperactivity disorder (ADHD) is a common childhood-onset neurodevelopmentaldisorder and may persist into adulthood. ADHD is a complex and heterogeneous disorder with a strong heritability estimation averaging 75% in children. Recent studies recommended a role for the γ-aminobutyric acid (GABA) on ADHD etiology due to behavioral disinhibitioncaused by inappropriate modulation of glutamatergic and GABAergic signaling.The glutamic acid decarboxylase (GAD1) gene encodes a key enzyme of GABA biosynthesis. Aim of the Study: The study aims to explore the potential association between attention deficit \hyperactivity disorder (ADHD) and glutamic acid decarboxylase.....

Key Words: ADHD; GABA; GAD1; susceptibility; association

Abstract: The application of diesel oil as the continuous phase of drilling mud is widespread when drilling through sensitive producing formation and troublesome shale zone. Due to the increase in environmental issues associated with the disposal of used fossil diesel, drilling companies are in recent times exploring options of use of environmentally friendly degradable oil as based for drilling fluids formulation. In this study, bio-lubricant also called polyol ester was formulated from biodiesel also called CAOFAME (chrysophyllum albidum oil fatty acid methyl ester) synthesized from vegetable oils extracted from chrysophyllum albidum (African star apple) fruit seed. The study also characterized the oils extracted against other vegetable oils. In addition, physiochemical properties of petroleum diesel oil, CAOFAME and polyol ester were examined against ASTM standards for purposes....

Key Words: chrysophyllum albidum seed oil, biodiesel, bio-lubricant, environmentally friendly

Abstract: Water pollution occurs when pollutants are directly or indirectly discharged into water bodies without adequate treatment to remove harmful compounds. Phenol along with other xenobiotic compounds is one of the most common organic pollutants present in effluents from chemical process industries. Due to the high toxicity of phenols, they are strictly regulated and their industrial use is increasingly avoided by substituting them with harmless compounds. Phenol contaminants are relatively soluble in water and accumulate in soil, resulting in extensive surface water, ground water and soil contamination owing to its severe toxicity. Materials: Bacillus pumilus strain SCH2JF914985, a newly phenol-degrading bacterium with high biodegradation activity and high....

Key Words: Phenol, Bacillus pumilus strain SCH2JF914985, HPLC

Abstract: Background: Justicia carnea is a medicinal plant reported to have diverse pharmacological functions including blood boosting potentials. Diabetes mellitus is one of the most common endocrine disorders accompanied with many metabolic syndromes. Use of herbal medicines has always been an option to treat a great number of diseases such as cancer, diabetes and its complications. The aim of this study was to evaluate the effects of ethanol extract of Justicia carnea on the biochemical parameters of alloxan-induced diabetic rats. Materials and Method: Acute toxicity test was done using Lorke's method. Thirty (30) albino wistar rats of both sexes were assigned into five (5) groups of six (6) rats. All rats, except the normal control group, were induced with diabetes by single intraperitoneal injection of 150 mg/kg alloxan. Group A (normal control) received water, group B received the standard drug; glibenclamide (0.1mg/kg) orally, Group C (diabetic control) received water while Groups D and E received 100 and 200mg/kg body weight of the extract orally once per day respectively. Treatment lasted for 14 days.....

Key Word: Alloxan-induced, Diabetic, Justicia carnea, ethanol, Biochemical parameters, Lipid profile

Abstract: Electricity is a form of energy resulting from charged particles (such as electrons or protons), either statically as an accumulation of charge or dynamically as a current. Microorganisms are ubiquitous and are used in almost all industries to produce specific products. They are termed as "the degraders" of the environment. They utilize a wide range of substrates in order to survive. This property is harnessed for the production of electricity. The biochemical interactions are converted into electricity. They act as catalysts for the production of electricity utilizing a wide range of substrate which helps generate power. Microorganisms were isolated....

Key Word: MFC, LED, Degraders, DC, AC, Cooum.

Abstract: The use of compost is very important to sustainable crop growing. Plant growth-promoting bacteria (PGPB) were studied in this work to affect the enlargement, yield and nutrient uptake by a selection of methods. Seven various plant growth-promoting characters and antagonistic capacity was selected to screen bacteria isolated from various composts. Growth supporting capability of bacteria was studied on seed germination and biomass of plant. Ten isolates stand on various plant growth-promoting characters and seed vigor index were estimated at greenhouse for plant growth-promoting action on pearl millet. Maximum increase in plant weight was by P. fluorescens ISR 33 (1110 mg), S. marcescens ISR75 (772 mg). Plant growth-promoting action of composts and bacteria was considered....

Key Word: PGPB, Compost, Seed germination, Biomass, Greenhouse, Pearl millet