Volume-7 ~ Issue-3 ~May – June 2021

Abstract: The wonder plant Jatropha is commonly known as American purging nut, Barbados nut, curcas bean, hell oil. Jatropha curcas belongs to the family EUPHORBIACEAE (Spurge family) which is a flowering plant. It is native to the tropical areas of the Americas from Mexico to Argentina and has been spread throughout the world in tropical and subtropical regions around the world. It's distribution became cosmopolitan slowly according to the time. It is a prominent cash crop which is a perennial, C3 plant and it's a prominent source of biodiesel. It can thrive in poor and stony soils, although new research suggests that the plant's ability to adapt to these poor soils is not as extensive as had been previously stated.

Abstract: Metastatic neuroendocrine tumors, just like other tumors, are difficult to treat because of the uncontrolled cellular growth that they exhibit. This paper seeks to review research on the treatment of neuroendocrine tumors as conducted by different scholars in order to develop the theoretical foundation for the current study. The paper is organized to include eight subsections that include treatment of neuroendocrine tumors, the importance of peptide receptor radionuclide therapy, methods of peptide receptor radionuclide therapy, radiolabelled 177Lu-DOTATOC therapy, and everolimus therapy for neuroendocrine tumors. Other subsections include somatostatin receptor affinity in somatostatin-based radionuclide therapy, the success of radiolabelled somatostatin analogs in targeted......

Abstract: In Cuba, garlic (Allium sativum L.) production has a low productivity, due to biotic and abiotic factors that affect the quality of the available seed. A methodology for the regeneration of plants from somatic embryogenesis is an alternative for seed production with good physiological quality and for its use in the genetic breeding of the crop. This methodology allows obtaining high multiplication coefficients in a shorter period of time than the conventional one, besides it lowers production costs, constituting an advantage over conventional in vitro propagation methods. The plant material disinfection protocol was adjusted to reduce the microbial contamination in the establishment. For in vitro establishment, the recommended culture medium was used with the addition of VIUSID Agro® to the culture medium in concentrations of 2.5 ml.L-1. For the induction and multiplication of calluses, the most suitable culture medium was determined, which was constituted with salts and vitamins MS 50......

Key Word: garlic, disinfection, embryogenesis, germination, maturity

Abstract: Human Serum Albumin (HSA) is the most prominent and abundant protein in blood plasma. Deficiency of HSA may cause hypoalbuminemia which is an indicator of cancer. In this study HSA has been quantified in blood samples from nine different cancer patients before (pre) and after (post) first dose of applied chemotherapy drug. Albumin has been quantified by the auto-ranging path length capability of NanoDrop™ 2000. Optical properties of these samples have also been measured. Nonlinear optical properties of human serum albumin from the same human blood plasma has been measured by the Z-scan technique. Change in albumin concentration in the blood serum of a cancer patient undergoing chemotherapy with the corresponding change in nonlinear optical (NLO) response has been calculated. Data analysis reveals a regular change in albumin concentration and a substantial change in the NLO response due to the application of the chemo-drug

Key Word: NanoDrop™ 2000, HSA, Nuclease Free Water, PBS, 0.9% NaCl, Z-Scan, Plasma, Chemotherapy, Nonlinear Optical Response (NLOR).

Abstract: This study was designed to examine the genetic polymorphism of TLR7 gene in the Nigerian indigenous chicken populations and ISA Brown commercial layer chicken. The study population comprises eight (8) chicken groups (naked neck, normal and frizzled-feathered Nigerian indigenous chickens in rain forest and Guinea Savannah regions respectively, Fulani ecotype chicken and ISA Brown commercial layer chicken). Blood samples were collected from each of the eight chicken groups. Genomic DNA was isolated from each blood sample using the Zymo Quick-gDNATM Miniprep kit (D3024, Zymo Research Corporation, Irvine, CA, USA) following the manufacturer's instructions. The DNA sequencing of was done using the Sanger Sequencing Chemistry.26 novel single nucleotide polymorphisms.....

Key Word: Chicken, diversity, intronic region, indels, mutations, Toll-like-rceptor

Abstract: Peptide-based radiopharmaceuticals comprise of three components that include a chelating agent, a radionuclide, and a peptide. Some of the commonly used chelating agents in the development of radiopharmaceuticals include DOTA, DPTA, and DOTATE, amongst others, while some of the commonly available radionuclides used in cancer therapies include iodine-131, samarium-153, strontium-89, yttrium-90, ruthenium-106, palladium-103, cobalt-60, caesium-137 and iridium-192 (Delgado, 1995). On the other hand, one of the commonly used peptides, in this case, is somatostatin and its analogs. The development of peptide-based radiopharmaceuticals is highly dependent on coordination chemistry. In the following sections, the significance of coordination chemistry in the development of anti-cancer peptide-based radiopharmaceuticals is discussed.

Abstract: Background: Pleural effusion is the commonest case admitted in IPD of Dept. of Respiratory Medicine/Internal Medicine. Untreated tuberculous pleural effusion (TPE) can develop into active tuberculosis so it is important to make rapid and accurate diagnosis for TPE and initiation of treatment. Adenosine deaminase level in pleural fluid is a cost effective diagnostic chemical biomarker having high sensitivity and specificity of 100% and 95% respectively for diagnosis of tubercular pleural effusion and is routinely employed as a screening tool in countries where tuberculosis is endemic......

Key Word: tuberculosis, exudative pleural effusion, adenosine deaminase, sensitivity, specificity