Series-1 (Sep. – Oct. 2021)Sep. – Oct. 2021 Issue Statistics
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Abstract: The objective of this paper is to determined the concentration levels of some mineral elements, vitamins and proximate composition of the roots of goose grass (Eleusin indica) and pawpaw (Carica papaya) to ascertain their nutritional and medicinal potentials, using standard methods. The result obtained showed the concentration level of calcium (Ca), phosphorus (P), sodium (Na), Magnesium (Mg) and potassium (K) in pawpaw (Carica papaya) to be (0.05±0.01 g/100g, 0.00±0.00 m/100g, 0.01±0.02 g/100g, 0.00±0.03 g/100g and 0.01±0.01 g/100g, respectively; while those of goose grass (Eleusin indica) were 0.04±0.02 g/100g, 0.00±0.00 g/100g, 0.01±0.01 g/100g, 0.00±0.01 g/100g and 0.01±0.03 g/100g respectively. The concentration levels of vitamin A, B1, C and D in pawpaw (Carica......
[1]. Adame, I. (2002). "Leaf absorption of mineral nutrients in carnivorous plants stimulates root nutrient uptake" (PDF). New phytologist, 155:89-100.
[2]. Adrogue, H. J. and Madias, N. E. (2014). The impact of sodium and potassium on hypertension risk. Semin Nephro, 34(3):257-272.
[3]. Ahmad, N., Fazal, H., Ayaz, M., Abbasi, B. H., Mohammad, I. and Fazal, L. (2011). Denque fever treatment with Carica papaya leaves extracts. Asian pac J. Trop Biomed, 1(4):330-333.
[4]. Alobi, N. O., Enyi-Idoh, K. H., Okoi, A. I., Abara, A. E. and Eja, M. E. (2013). Vitamin profiles of cnidoscolus carumbium (Hospital no far) and spigelia marilandica (worm grass). Journal of Science, Engineering and Technology, 2(2):59-61.
[5]. Al-Harrasi, A., Al-Rawahi, A., Hussain, J., Rehman, N., Ali, L. and Hussain, H. (2012). Proximate analysis of the resins and leaves of Boswellia Sacra. J. Med. Plants Res. 6(16):3098-3104.
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Abstract: Background: Analgesia, one of the components of triad of anaesthesia, has now extended to relief of postoperative pain, chronic pain and cancer pain. The spinal cord has taken the center stage in analgesia practice and Spinal anaesthesia is the commonly used technique for lower limb surgeries as it is easy to administer, economical and causes less hemodynamic variation than general anaesthesia. Hence different additives can be used to increase the duration of postoperative analgesia. Since there are no studies comparing Buprenorphine and Nalbuphine, we have selected this study to evaluate the effect of intrathecal Bupivacaine with Buprenorphine compared with Nalbuphine.......
Keywords: Intrathecal; Bupivacaine; Buprenorphine; Nalbuphine; Postoperative analgesia
[1]. Abubakar E.M. Efficacy of crude extract of garlic (Allium SativumLinn) against nacosomial Escherichia coli, Staphylococcus aureus, Streptococcus pneumonia and Pseudomonas aeruginosa. Journal of Medical Plant Research 2009 pp. 179 – 185 3 (4).
[2]. Ahmed, Z., Khan, S.S., Khan, M., Tanveer, A. and Lone Z. A. Synergy effect of Salvadorapersica extract, Tetracycline and Penicilline against Staphylococcus aureus. African Journal of Basic and Applied Science 2010 pp. 25 – 29 2 (1-2).
[3]. Al- Astal, Z.Y. Effect of storage and Temperature of aqueous garlic extract on the growth of certain pathogenic bacteri. Journal of Al azhar University – Gaza 2003 pp. 11- 20, 6 (2)
[4]. Amagase, H. Significance of garlic and its Constituent in Cancer and cardiovascular Disease. The Journal of Nutrition [Online], 136, pp. 716S – 725S 2015. Available at: http://www.Google.co.uk
[5]. Ankri, S. and Mirelman D. Antimicrobial properties of Allicin from Garlic. Microbes and Infection [Online] 2, pp. 125 – 129 2015. Available at http://www.Sciencedirect.co.uk.
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Abstract: The present research was conducted to evaluate antioxidant potentials of Alpina muricata leaf extracts. Extracts were prepared from the leaf of the plant with aqueous, ethanolic and ethylacetate solvents system at 5.0% concentration. Free radical scavenging ability using 2,2-diphenyl-2-pricrylhydrazyl [DPPH] and metal chelation ability of the leaf extracts were assessed. Results revealed significantly (P<0.05) high antioxidant potential obtained from both aqueous and ethanolic extracts which was comparatively higher than that obtained from ethylacetate extract. Highest DPPH inhibition (97%) was exhibited by aqueous leaf extract of Alpina muricata plant, followed by (60%) ethanolic extract while the least DPPH inhibition (56%) was obtained in ethylacetate leaf extract. Besides, highest metal.......
Key Word: Alpina muricata, 2,2-diphenyl-1-picryl hydrazyl, metal chelation, antioxidant potential.
[1]. Miron, D.M., Crestani, R.M., Schetinger, M.V., Morsch, B. (2005). Effect of herbicide clomazone, quinclorac and metsulfuron-methyl on acetylcholinesterase activity in silver catfish. Ecotoxicol. Saf. 61: 398-403.
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[3]. Usoh, I.F., Akpan, E.J., Etim, E.O., Farombi, E.O. (2005). Antioxidant action of dried flower extract of Habiscus sabdariffa.. L on sodium arsenite induced oxidative stress in rats. Pakistan journal of Nutrition , 4: 135-141.
[4]. Fejes, S.A., Blazovics, A., Lugasi, E., Lemberkovics, G., Kery, A. (2000). In vitro antioxidant activity of Anthriscus cerefolium (Hoffin) extracts. J. of Ethnopharmacol. 69: 259-265.
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Abstract: Objective: - The aim of this study was to find the association of Plasma IL-6 with Fibrinogen and t-PA in IHD subjects (STEMI subjects).
Materials and Methods: The study was conducted on 110 STEMI subjects and 110 age and gender matched healthy controls. Plasma IL-6, Fibrinogen and t-PA levels were estimated by ELISA technique. Difference in all the parameters between STEMI subjects and healthy subjects were analyzed by t-test and correlation between two parameters were accessed with Pearson's correlation test.
Results: STEMI subjects had significantly high levels of Plasma IL-6, Fibrinogen and t-PA when compared with healthy controls. A positive significant correlation was observed between IL-6 and Fibrinogen while a positive non-significant correlation between IL-6......
Key Word: IL-6, t-PA, STEMI, BMI, SBP, DBP
[1]. Gibbons RJ, Abrams J, Chatterjee K, Daley J, Deedwania PC, Douglas JS, Ferguson TB Jr, Fihn SD, Fraker TD Jr, Gardin JM, O'Rourke RA, Pasternak RC, Williams SV, Gibbons RJ, Alpert JS, Antman EM, Hiratzka LF, Fuster V, Faxon DP, Gregoratos G, Jacobs AK, Smith SC Jr; American College of Cardiology; American Heart Association Task Force on Practice Guidelines 2002. Committee on the Management of Patients with Chronic Stable Angina.
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[4]. Prabhakaran D, Jeemon P, Sharma M, et al.: The changing patterns of cardiovascular diseases and their risk factors in the states of India: the Global Burden of Disease Study 1990-2016. Lancet Glob Health. 2018, 6:1339-1351.
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Abstract: COVID-19 pandemic caused by the SARS-CoV-2 coronavirus shifted attention towards all the types of coronaviruses that have emerged in the last few years and have shown their presence among humans. These include SARS-CoV, MERS and SARS-CoV-2 causing severe symptoms in humans and some other coronaviruses that cause fevers and common respiratory symptoms. Two of the most important viruses that have caused severe symptoms in humans are the 2003 coronavirus SARS-CoV and the 2019 coronavirus SARS-CoV-2. Here, we have gone through the various similarities and dissimilarities of the two viruses in terms of their origin, phylogenetic background, structure, genomic composition as well as the immune response the body shows against infection due to these.....
Key Word: SARS-CoV, SARS-CoV-2, Open reading frames (ORF), Angiotensin converting enzyme-2 (ACE-2), Spike protein
[1]. Iman Salahshoori, Noushin Mobaraki-Asl, Ahmad Seyfaee, Nasrin Mirzaei Nasirabad, et al. Overview of COVID-19 Disease: Virology, Epidemiology, Prevention Diagnosis, Treatment, and Vaccines. Biologics 2021, 1(1), 2-40. https://doi.org/10.3390/biologics1010002
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Abstract: Human Serum Albumin (HSA) is the most prominent and abundant protein in blood plasma. Deficiency of HSA may cause hypoalbuminemia which is an indicator of cancer. In this study HSA has been quantified in blood samples from nine different cancer patients before (pre) and after (post) first dose of applied chemotherapy drug. Albumin has been quantified by the auto-ranging path length capability of NanoDrop™ 2000. Optical properties of these samples have also been measured. Nonlinear optical properties of human serum albumin from the same human blood plasma has been measured by the Z-scan technique. Change in albumin concentration in the blood serum of a cancer patient undergoing chemotherapy with the corresponding change in nonlinear optical (NLO) response has been calculated. Data analysis reveals a regular change in albumin concentration and a substantial change in the NLO response due to the application of the chemo-drug.
Key Word: NanoDrop™ 2000, HSA, Nuclease Free Water, PBS, 0.9% NaCl, Z-Scan, Plasma, Chemotherapy, Nonlinear Optical Response (NLOR)
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[3]. Satoshi Ikeda, Hiroshige Yoshioka, Satoshi Ikeo, Mitsunori Morita, Naoyuki Sone, Takashi Niwa, Akihiro Nishiyama, Toshihide Yokoyama, Akimasa Sekine, Takashi Ogura, Tadashi Ishida. Serum albumin level as a potential marker for deciding chemotherapy or best supportive care in elderly, advanced non-small cell lung cancer patients with poor performance status. BMC Cancer. 2017; 17: 797. Published online 2017 Nov 28.
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Abstract: Background: Deltamethrin insecticide showed severe toxicity to testicular tissues regarding damages in their architecture, deterioration in fertility hormones secretion and severe anomalies in their structure. However, selenium nanoparticles exhibit protective role that can recover such damages, anomalies and strengthen the reproductive potency as well. The aim of this study was to investigate the effect of selenium nanoparticles on the expression of the proliferating cell nuclear antigen (PCNA) gene in testes of rats treated with 13.5 mg/ kg bwt and 27 mg/Kg bwt deltamethrin corresponding to its 1/10 and 1/5 LD50 using corn oil as a solvent for 28 days. Materials and Methods: In this prospective five groups each of ten adult albino male rats were considered. One group was the control with rat fed.......
Key Word: Deltamethrin, Proliferating cell nuclear antigen (PCNA), Selenium nanoparticles, Testicular immunocytochemistry, Testicular histology.
[1]. Sharma P, Singh R, Jan M. Dose-dependent effect of deltamethrin in testis, liver, and kidney of wistar rats.Toxicol Int 2014, 1(2):131-9. doi: 10.4103/0971-6580.139789.
[2]. Rashid A, Nabiha Zara AN and Ara C. Testicular toxicity induced by deltamethrin in Albino mice. J. 20012012,.44: 1349-1353.
[3]. Rana T. Nano-selenium on reproduction and immunocompetence: an emerging progress and prospect in the productivity of poultry research Reviews: Tropical Animal Health and Production . 2021, 53, 324.
[4]. Zhang J, Wang X, Xu T. Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with semethylselenocysteine in mice. Toxicol Sci; 2008, 101:22-31.
[5]. Abd-Allah S, Hashem KS. Selenium nanoparticles increase the testicular antioxidant activity and spermatogenesis in male rats as compared to ordinary selenium. Int J Adv Res. 2015, 3:792-802.
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Abstract: HIV breaks down the body's immune system and progressively leads to Acquired Immune Deficiency Syndrome, a fatal illness, prevalent more in Africa, Nigeria inclusive. Patients infected with HIV have an increased risk of developing heart disease. Information on cardiac status in HIV infected subjects in Nigeria is scanting. The study assessed the impact of HIV infection on serum Apolipoprotein and lipid profiles.A total of 390 (M = 220, F = 170) subjects were studied.The subjects were grouped based on WHO criteria for staging HIV infection Symptomatic HIV on Antiretroviral therapy (ART), Symptomatic HIV not on ART, Asymptomatic HIV subjects andHIV seronegative controls.Enzyme linked Immuno Assay (ELISA) was used for Apolipoproteins, Myoglobin and Troponin I. Spectrophotometric method......
Key Word: Apoliporotein, lipid, HIV, CK-T, CK-MB
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