Abstract: Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder in which pathological changes can occur years before clinical symptoms become apparent. Early detection is therefore important for timely intervention. Current diagnostic methods include cognitive assessments, neuroimaging, and biomarker analysis, but these approaches may not reliably identify the disease during its earliest stages and can be expensive or difficult to implement for large-scale screening. Machine learning (ML) has increasingly been applied to this problem because it can identify patterns within complex biomedical datasets.......
Key Word: Alzheimer’s disease; Machine learning; Deep learning; Multimodal data; Early diagnosis; Neurodegenerative disorders.
[1]
ADI - Dementia statistics. (n.d.). ADI - Dementia Statistics. https://www.alzint.org/about/dementia-facts-figures/dementia-statistics/
[2]
World Health Organization. (n.d.). Dementia. https://www.who.int/news-room/fact-sheets/detail/dementia
[3]
Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Dunn, B., Haeberlein, S. B., Holtzman, D. M., Jagust, W., Jessen, F., Karlawish, J., Liu, E., Molinuevo, J. L., Montine, T., Phelps, C., Rankin, K. P., Rowe, C. C., Scheltens, P., Siemers, E., Snyder, H. M., & Sperling, R. (2018). NIA-AA research framework: Toward a biological definition of Alzheimer’s disease. Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association, 14(4), 535–562. https://doi.org/10.1016/j.jalz.2018.02.018
[4]
Soni, P., Hasan, S. M., Kushwaha, S. P., Singh, K., Kumar, A., Hafeez, A., Suvaiv, Samman, & Khan, S. (2025). Amyloid beta and tau aggregation: The etiology and potential pharmaceutical approaches for Alzheimer’s disease. Biomedical Research and Therapy, 12(9), 7708–7722. https://doi.org/10.15419/rjv09v43
[5]
Aksman, L. M., Oxtoby, N. P., Scelsi, M. A., Wijeratne, P. A., Young, A. L., Alves, I. L., Collij, L. E., Vogel, J. W., Barkhof, F., Alexander, D. C., Altmann, A. (2023). A data-driven study of Alzheimer’s disease related amyloid and tau pathology progression. Brain, 146(12), 4935–4948. https://doi.org/10.1093/brain/awad232