Abstract: With the availability of dinoprostone sustained release vaginal pessary in India, for induction of labour (IOL), this study was planned with the aim of studying its clinical efficacy and comparing it with another preparation of dinoprostone which has been available and being used since years for IOL, i.e. instant released intracervical gel. Different study from west has shown the vaginal dinoprostone to be safe and efficacies for IOL, and PGE2 in different forms of tablets, gel and pessary appear to be equally efficacies. The vaginal preparation has an advantage of single application, slow and sustained release of drug over 24 hours, less invasiveness, ease of administration and removal allowing greater dose control. Patients selected for induction were offered sustained release vaginal preparation and intracervical preparation alternatively and relevant data were collected for first 100 patients for each group. There was statistically insignificant difference between the two groups in parity, gestational......
Key words: Induction of Labour, dinoprostone, vaginal pessary, intracervical gel.
[1]. Kandemir O, Dede H, Yalvac S, Aldemir O, Yirci B, et al., "The Effect of Parity on Labor Induction with Prostaglandin E2 Analogue (Dinoprostone): An Evaluation of 2090 Cases", J Preg Child Health April 15, 2015;2:149. [2]. Swartout JP, Ramin KD (2008), "Controlled-release dinoprostonevaginal insert for cervical ripening and labor induction", Expert RevObstetGynecol 3:13-20. [3]. NICE Clinical Guideline number 70, "Induction of Labour" (update of NICE inherited clinical guideline D) National Collaborating Centre for Women's and Children's Health (UK) London: RCOG Press; July, 2008.
[4]. Leduc, D., Biringer, A., Lee, L., and Dy, J. Clinical Practice Obstetrics Committee, Society of Obsetricians and Gynaecologists of Canada. Induction of labour. SOGC Clinical Practice Guideline No. 296, September 2013. J ObstetGynaecol Can. 2013; 36: 248–252.
[5]. DINOPROSTONE 10mg Vaginal Insert in 241 mg hydrogel polymer (cross-linked polyethylene oxide/urethane) with polyester retrieval system. FERRING PHARMACEUTICALS, (Manufactured For: Ferring Pharmaceuticals Inc). Parsippany, Nj 07054 Rev. 02/2016 6870-03..