Abstract: Summary: Many factors are likely to influence the subjective assessment of quality of life by people with schizophrenia. Among clinical factors, emotional disturbance and depression are most frequently reported to have a major negative influence on subjective quality of life, while positive or negative clinical manifestations have little impact on this measure. These subjective manifestations have a significant impact on the non-observance of care strategies and probably on the emergence of depressive disorders or suicidal ideation; the relationship between akathisia and suicide is for example widely documented in the literature. Improvement of cognitive functions is often associated with better autonomy in daily life. The awareness of the disorders and the improvement of cognitive functioning cannot totally exclude the risk of deterioration in the subjective quality of life of patients and potentially the appearance of depressive disorders..
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