iosr-JDMS   Volume-21 ~ Issue-12 ~ Dec. 2022

Abstract: Background: Rheumatic heart disease (RHD) is the commonest acquired heart disease in India and other developing countries.This study was undertaken to determine the incidence of RHD with pregnancy and to study the maternal and fetal outcomes in pregnancy complicated by RHD in our institution. Methods: This study enrolled all pregnant patients presenting at RIMS labour room and OPD with Rheumatic heart disease. Based on inclusion criteria, the patients were admitted and followed up. Results and conclusion: The results of this study showed that the incidence of heart disease was 1.2% for all deliveries occurring during our study......

Keywords: RHD, pregnancy

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[3]. Vera Regitz, Zagrosel et al, Task force on management of CVD during pregnancy of ESC, European heart Journal 2011; 32: 3147-97.
[4]. Liah H, Xu JW, Zhao XD et al, Pregnancy outcomes in women with heart diseases, Chin Med J 2010 Sep: 123(17) 2324-30.
[5]. Moor L, Benjamin EJ, et al Effectiveness based guidelines for the prevention of cardiac disease in women 2011, AHA Circulation 2011; 123:1243-62.

Abstract: Background:The pathologies of the anorectal region are manifested by multiple and varied symptoms. Their diagnosis requires a meticulous and well-conducted proctologic examination. The aim of this work is to seek a correlation between the proctological complaints and the diagnoses found in the proctological clinical examination as well as to study the diagnostic contribution of each stage of the proctological clinical examination. Materials and Methods:This is a descriptive and analytical retrospective study conducted over 3 years. Including patients aged over 16 consulting for a proctological reason and benefiting from a proctological examination with good anal......

Key Word: Proctological examination; Proctalgia; rectal bleeding; Haemorrhoidal disease

[1]. Tarrerias A, Garros A. Proctologie en endoscopie. Acta Endosc.2016 ; 46, 330–335 .
[2]. Pravin J.GuptaRevistaMexicana de Coloproctología Vol. 10, No. 3 Septiembre-Diciembre 2004 pp 21-31.
[3]. Kuehn H,Gebbensleben O, Hilger Y, Rohde H. Relationship between anal symptoms and anal findings. Int J Med Sci. 2009;6(2):77-84.
[4]. Tournu G, Abramowitz L, Couffignal C, et al. Prevalence of anal symptoms in general practice: a prospective study [published correction appears in BMC Fam Pract. 2019 Jan 17;20(1):14.
[5]. Abramowitz L, Benabderrahmane M, Pospait D, Philip J, Laouénan C. The prevalence of proctological symptoms amongst patients who see general practitioners in France. Eur J GenPract. 2014;20(4):301-306

Abstract: Background: Loculated effusions are one form of complicated pleural effusions that were difficult to manage in the olden times, but it has become easier now with the invention of newer techniques like intrapleural fibrinolytic therapy with drugs like streptokinase ,urokinase etc.along with tube thoracostomy (ICT insertion).Hence we have selected this study to assess and compare the management of loculated effusion in patients by insertion of Intercostal drain (ICT) alone and by intrapleural instillation of fibrinolytics like Streptokinase (STK) through ICT and also to study the residual pleural thickening by radiological follow up in the study sample........

Key Word: loculated effusions , tube thoracostomy , intra pleural streptokinase instillation

[1]. Avya Bansal, Amita Nene, Jyothi Hattiholi; Role of pleural irrigation with normal saline versus streptokinase in complicated pleural effusions, , European Respiratory Journal 2019 54: PA3133.
[2]. https://tbfacts.org/tb-statistics-india/
[3]. Sharma VP, Guleria R, Gupta R, Sharma SK, Pandey JN. Intrapleural streptokinase in multiloculated empyema thoracis. J Assoc Physicians India 1998; 46:227-9.
[4]. Barthwal MS, Deoskar RB, Rajan KE, Chatterjee RS. Intrapleural streptokinase in complicated parapneumonic effusions and empyema. The Indian journal of chest diseases & allied sciences. 2004 Oct 1;46(4):257-61.
[5]. Omar A, Elfadl AE, Ahmed Y, Refaat S. Using streptokinase for pleural adhesiolysis in sonographically septated pleural effusion. Egyptian Journal of Chest Diseases and Tuberculosis. 2015 Oct 1;64(4):793-7.

Abstract: Introduction: Diffuse large B-cell lymphoma (DLBCL) represents 30 to 40% of all non-Hodgkin's lymphomas. About 60% of patients are recovred with standard treatment. Targeted therapies, that may improve disease outcomes, are currently investigated; however, their effect on anticancer drug budgets seems to be huge. In our study, we analyzed the direct medical cost of DLBCL in our unit, to assess its impact and lead care management strategies and health plans. Methods: this is a retrospective study of patients diagnosed with DLBCL at the department of internal medicine and Onco-Hematology at Hassan II University Hospital in Fez in 2019. We evaluated the direct medical costs of managing newly diagnosed DLBCL......

Key Word: diffuse large B-cell lymphoma, direct medical cost, chemotherapy.

[1]. STRATÉGIE NATIONALE DE FINANCEMENT DE LA SANTÉ. rapport_SNFS VD avril 2021.pdf (sante.gov.ma).
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[3]. Morton LM, Wang SS, Devesa SS, Hartge P, Weisenburger DD, Linet MS. Profils d'incidence des lymphomes selon le sous-type de l'OMS aux États-Unis, 1992-2001. Blood 107(1), 265-276 (2006).
[4]. Wästerlid T, Harrysson S, Andersson TM, et al. Outcome and determinants of failure to completeprimary R-CHOP treatment for reasonsotherthannon-responseamong patients with diffuse large B-celllymphoma. Am J Hematol 2020; 95 : 740–8.
[5]. Décret n° 2-13-852.https://www.sante.gov.ma/Reglementation/TARIFICATION/2-13-852.pdf.
[6]. Best JH, Hornberger J, Proctor SJ, Omnes LF, Jost F. Cost-effectivenessanalysis of rituximab combinedwith chop for treatment of diffuse large B-celllymphoma. Value Health. 2005 Jul-Aug;8(4):462-70..

Abstract: Background The incidence of renal artery stenosis after transplant varies from 1% to 23 % and it has become an important curable cause of hypertension, graft dysfunction and graft loss in kidney recipients. We reported three cases of transplant renal artery stenosis which required interventions. Materials and methods Between January 2012 and December 2016, three patients required interventions for renal artery stenosis (RAS) following live related renal transplant in Department of Urology in Christian Medical College, Vellore. Clinical manifestations, diagnosis and outcomes were analyzed retrospectively. Results and observations........

Key Word: Renal artery stenosis, transplant, angioplasty, hypertension, angiogram

[1]. Fervenza FC, Lafayette RA, Alfrey EJ, Petersen J. Renal artery stenosis in kidney transplantation. Am J Kid Dis 1998; 31:142-148.
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[3]. Krishnamoorthy S, Gopalakrishnan G, Kekre NS, Chacko N, Keshava S, John G. Detection and treatment of transplant renal artery stenosis. Indian J Urol 2009; 25:56-61
[4]. Hurst FP, Abbott KC, Neff RT, et al. Incidence, predictors and outcomes of transplant renal artery stenosis after kidney transplantation: analysis of USRDS, Am J Nephrol , 2009;30: 459-67
[5]. Roberts JP, Ascher NL, Fryd DS, et al. Transplant renal artery stenosis, Transplantation, 1989; 48: 580-83.
[6]. Riehl J, Schmitt H, Bongartz D, Bergmann D, Sieberth HG. Renal artery stenosis: Evaluation with colour duplex ultrasonography. Nephrol Dial Transplant 1997; 12:1608-14

Abstract: Background: Autologous arterio-venous access is the key to long-term success for hemodialysis. Basilic vein transposition (BVT) fulfills the need for a durable conduit with high patency and maturation rates. This retrospective review showed a single centre experience with this procedure. Materials and methods: All patients undergoing BVT between January 2010 and December 2016 in Christian Medical College, Vellore, Tamilnadu, India for hemodialysis with available follow-up data were reviewed retrospectively. Functional patency was used as the end point for this procedure. Results: Twenty nine patients underwent BVT between January 2010 and December 2016 in department of Urology of Christian Medical College, Vellore, Tamilnadu. There were 18 male (62%) and 11 female (38%) patients. Mean age was 52.5.....

Key Word: Basilic vein transposition (BVT), arterio-venous fistula (AVF), patency

[1]. Dagher F, Gelber R, Ramos E, Sadler J. The use of basilic vein and brachial artery as an A-V fistula for long term hemodialysis. J Surg Res. 1976; 20: 373–376.
[2]. Yunhee Lee, Dan Song, Myung Jin Kim, and Sang Chul Yun. Upper Arm Basilic Vein Transposition for Hemodialysis: A Single Center Study for 300 Cases. Vasc Spec Int 2016;32(2):51-56.
[3]. Hakaim AG, Nalbandian M, Scott T. Superior maturation and patency of primary brachiocephalic and transposed basilic vein arteriovenous fistulae in patients with diabetes. J Vasc Surg. 1998; 27:154–157.
[4]. Tsai YT, Lin SH, Lee GC, Huen GG, Lin YF, Tsai CS. Arteriovenous fistula using transposed basilic vein in chronic hypotensive hemodialysis patients. Clin Nephrol. 2002; 57: 376–380.
[5]. Rao RK, Azin GD, Hood DB, Rowe VL, Kohl RD, Katz SG, et al. Basilic vein transposition fistula: a good option for maintaining hemodialysis access site options? J Vasc Surg. 2004; 39:1043–1047.

Abstract: Acute MI Care Outcomes In India, the care outcomes for acute MI patients indicate the constraints that these patients encounter as they attempt to play their roles in the delivery of their healthcare. Studies have found that the care outcomes for Indian MI patients are low in quality (Huffman et al., 2018). The low quality of care outcomes is evident in the fact that many of these patients continue to exhibit the symptoms of acute MI after they have received primary care (Huffman et al., 2018). The quality of the care outcomes shows that the care does not improve the condition of the acute MI patients, which in turn points to the possible role of the design of the care package for acute MI patients and other factors related.....

[1]. Huffman, M. D., Mohanan, P. P., Devarajan, R., Baldridge, A. S., Kondal, D., Zhao, L., ...&Prabhakaran, D. (2018). Effect of a quality improvement intervention on clinical outcomes in patients in India with acute myocardial infarction: the ACS QUIK randomized clinical trial. Jama, 319(6), 567-578.
[2]. Mackey, L. M., Blake, C., Casey, M. B., Power, C. K., Victory, R., Hearty, C., &Fullen, B. M. (2019). The impact of health literacy on health outcomes in individuals with chronic pain: a cross-sectional study. Physiotherapy, 105(3), 346-353.
[3]. Mathew, A., Hong, Y., Yogasundaram, H., Nagendran, J., Punnoose, E., Ashraf, S. M., ...& Graham, M. (2021). Sex and Medium-term Outcomes of ST-Segment Elevation Myocardial Infarction in Kerala, India: A Propensity Score–Matched Analysis. CJC open, 3(12), S71-S80.
[4]. Rymer, J. A., Kaltenbach, L. A., Anstrom, K. J., Fonarow, G. C., Erskine, N., Peterson, E. D., & Wang, T. Y. (2018). Hospital evaluation of health literacy and associated outcomes in patients after acute myocardial infarction. American heart journal, 198, 97-107.
[5]. Zachariah, G., Ramakrishnan, S., Das, M. K., Jabir, A., Jayagopal, P. B., Venugopal, K., ...& CSI-AMI Study group. (2021). Changing pattern of admissions for acute myocardial infarction in India during the COVID-19 pandemic. Indian heart journal, 73(4), 413-423..

Abstract: Background: Jaundice is the commonest abnormal physical finding during the first week of life. Over two third of newborn babies develop clinical jaundice develop clinical jaundice and by adult standard almost all newborns are jaundiced during early days of life. High level of unconjugated bilirubin cross blood brain barrier (BBB) and cause bilirubin encephalopathy/ Kernicterus. DVET is the most effective and reliable method to reduce birth level and prevent kernicterus. Material & Methods: This is a prospective cohort study. Neonates who underwent DVET for hyperbilirubinemia from 1st June 2021 to 31st December 2021 were included in the study. Results: One hundred and twelve neonates underwent DVET. ABO incompatibility was the commonest cause (40.2%). Hypocalcemia was a predominant complication, along with hypoglycemia. Conclusion: ABO incompatibility was the commonest cause for DVET. Very few neonates faced any adverse events. Mortality was 3.6%.

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[3]. Pradhan JB, Kamalarathnam CN. Clinical profiles and outcomes of neonatal hyperbilirubinemia and treated with double volume exchange transfusion: a retrospective study. Int J ContempPediatr, 2019 Sep 6(5): 2178-83
[4]. Kanodia P, Yadav SK, Bhatta NK et al. Clinical Profile and outcome of newborns who underwent double volume exchange transfusion in the neonatal intensive care unit at B.P. Koirala Institute if Health Sciences, Nepal. Sri Lanka J of Child Health, 2016, 45(4), 267-70.
[5]. Weng Yi-Hao, Chiu Ya-Wen. Spectrum and Outcome Analysis of Marked Neonatal Hyperbilirubinemia with Blood Group Incompatibility. Chang Gung Med J 2009; 32:400-8.

Abstract: Vaginal birth after cesarean section (VBAC) is one of the strategies developed to control the rising rate of cesarean sections (CS). It is a trial of vaginal delivery in selected cases of a previous CS in a well-equipped hospital. In 1916, Cragin popularized the dictum, "once a caesarean section, always a caesarean section". That was the era of the classical CS. In the present era of lower segment caesarean section (LSCS), cesarean-related morbidity and mortality are significantly reduced. The dictum now is "once a caesarean section, always an institutional delivery in a well-equipped hospital". The reasons which led to the reversal of the old dictum are based upon the newer concepts of the assessment of scar integrity, fetal well-being, and improved facilities of emergency CS.

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Abstract: INTRODUCTION: Ventriculoperitoneal shunt (VPS) placement is an established procedure for the treatment of hydrocephalus in children and adults. An Abdominal pseudocyst of cerebrospinal fluid, a rare complication and usually occurs after a period of successful surgery. We report a case of abdominal pseudocyst following a VPS surgery. CASE DESCRIPTION : A30 year-old female reported with abdominal distension of 2months duration with diffuse abdominal pain. The patient had a history of undergoing a VPS surgery 3 years earlier for hydrocephalus secondary to brain abscess. Abdominal computed tomography (CECT) revealed a homogeneous low-density multi loculated fluid collection with the tip of VPS catheter within the collection. A peritoneal pseudocyst around chant catheter was suspected and laparotomy was performed...........

Key word: VP shunt-Pseudocyst abdomen-excision-reposition.

[1]. Kashyap S, Ghanchi H, Minasian T, Dong F, Miulli D. Abdominal pseudocyst as a complication of ventriculoperitoneal shunt placement: Review of the literature and a proposed algorithm for treatment using 4 illustrative cases. Surg Neurol Int 2017;8:78. [2]. Atsumi Tamura1, Dai Shida2* and Kyosuke Tsutsum.Abdominal cerebrospinal fluid pseudocyst occurring 21 years after ventriculoperitoneal shunt placement: a case report.BMC Surgery 2013, 13:27
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Abstract: Background: Dengue is one of the most important cause of significant morbidity in last 2 decades .There are 4 serotypes of dengue , For promt and adequate treatment early diagnosis is important .Diagnosis is based on clinical features and serology ,but serology is time consuming .The main aim of study is role of ultrasound of abdomen and thorax by using it as an adjuvant in evaluating dengue fever in clinically serologically positive patient and to known the severity of dengue . Materials and Methods: This prospective comparative study was carried out on patients of ( at Department of radiology ) MAHARAJA 'S INSTITUTE OF MEDICAL SCIENCES ,Nellimarla, Vizianagaram from November 2020 to November 2022. Study was done 50 patients who have clinically symptomatic and serologically positive for dengue (NS1 AG) ,referred to department of radiology for ultrasound abdomen and thorax......

Key Word: GALL BLADDER WALL THICKENING ,ASCITES ,PLEURAL EFFUSION

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[4]. Laing FC, Federle MP, Jeffrey RB, Brown TW. Ultrasonic evaluation of patients with acute right upper quadrant. Radiology. 1981;140(2):449-55. [5]. [5]Rigau-Pérez JG, Clark GG, Gubler DJ, et al. Dengue and dengue haemorrhagic fever. Lancet. 1998 Sep 19;352(9132):971-7.[pubmed]

Abstract: Background: Adjunctive local periodontal therapy is one of the best options to improve the health of the pocket tissue. The comparison of local effects of simvastatin and Lepidium sativum as an aid in reinforcing the healing of periodontal tissue is a point of importance.The objective of this work was to evaluate theeffectiveness of the local application of Lepidium sativum versus simvastatin gel on clinical parameters and nuclear factor kappa B biomarker. Subjects and methods: The current study was conducted on thirty patients selected in this study with localized periodontitis stages (II, and III).....

Key Word: Periodontitis; Non-surgical therapy; Lepidium sativum; Simvastatin, Nuclear factor kappaB

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[4]. Gölz L, Memmert S, Rath-Deschner B, Jäger A, Appel T, Baumgarten G, et al. Hypoxia and P. gingivalis synergistically induce HIF-1 and NF-κB activation in PDL cells and periodontal diseases. Mediators Inflamm [Internet]. 2015;2015:438085. Available from: http://dx.doi.org/10.1155/2015/438085
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Abstract: Hemophilia is a rare X-linked bleeding disorder caused by a deficiency of coagulation factors Factor VIII and Factor IX. Hemophilia can also be acquired due to autoimmune antibodies developed against factor VIII and factor IX. Management of acute bleeding mainly by coagulation factor replacement therapy is the core stone treatment of hemophilia. Development of antibodies(inhibitors) against FVIII or FIX concentrates is a major complication. Hemophilia replacement therapy requires extensive time period and constant monitoring of patients on factor levels, development of inhibitors,etc. Many researches and clinical trials are ongoing in order to develop a cost effective single....

Key Word: Hemophilia, Gene therapy, Hemostasis,Adeno-associated virus vector, Lentiviral vector

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