iosr-JDMS   Volume-22 ~ Issue-6 ~ June 2023

Abstract: Background: diabetes mellitus is the most common health problem and one of the most challenging.1 Foot ulcers are a common complication of diabetes and represent a major source of morbidity. The incidence of foot ulcers with diabetes is around 2% per year.2 A clinical severity score is considered to be superior to a classification system .A severity scoring system called Diabetic ulcer severity score (DUSS) considering the four clinically defined parameters, namely palpable pedal pulses, probing to bone, ulcer location and presence of multiple ulcerations to outcome this problem, and have found that healing was independently associated with Peripheral arterial disease, ulcer depth & site and ulcer number. Materials and Methods: In this prospective.......

Key Word: diabitic ulcer scoring system, amputation.

[1]. McInnes AD. Diabetic foot disease in the United Kingdom: about time to put feet first. J Foot Ankle Res. 2012 Oct 11;5(1):26.
[2]. Lazzarini PA, Gurr JM, Rogers JR, Schox A, Bergin SM. Diabetes foot disease: the Cinderella of Australian diabetes management? J Foot Ankle Res. 2012 Oct 1;5(1):24.
[3]. Ramsey SD, Newton K, Blough D, McCulloch DK, Sandhu N, Reiber GE, et al. Incidence, outcomes, and cost of foot ulcers in patients with diabetes. Diabetes Care. 1999 Mar;22(3):382–7.
[4]. Wieman TJ. Principles of management: the diabetic foot. Am J Surg. 2005 Aug;190(2):295–9.
[5]. Beckert S, Witte M, Wicke C, Königsrainer A, Coerper S. A new wound-based severity score for diabetic foot ulcers: A prospective analysis of 1,000 patients. Diabetes Care. 2006 May;29(5):988–92..

Abstract: Invasive lobular carcinoma of the breast is the second most prevalent subtype of breast cancer. It constitutes 5 – 15 % of all invasive breast cancers(1). Invasive lobular carcinoma may produce intracellular mucin-producing characteristic signet ring cell morphology by pushing the nucleus to one side(2). Carcinoma of ductal origin is usually related to extracellular mucin production. Recently a new rare variant of invasive lobular carcinoma with extracellular mucin has been described(1). In this manuscript, we report a case of invasive lobular carcinoma with extracellular mucin production with an emphasis on clinico-pathological features.

Keywords: Breast, invasive lobular, mucin

[1]. Lyon et al: WHO classification of tumours. breast tumours. (2019) 5th edn 82-102 . International Agency for Research on Cancer.
[2]. Haltas et al.: Invasive lobular carcinoma with extracellular mucin as a distinct variant of lobular carcinoma: a case report. Diagnostic Pathology 2012 7:91.
[3]. Boukhechba, M., Kadiri, H. and El Khannoussi, B. "Invasive lobular carcinoma of the breast with extracellular mucin: Case report of a new variant of lobular carcinoma of the breast," Case Reports in Pathology, 2018, pp. 1–3.
[4]. Bari, V.B. "Invasive lobular carcinoma of the breast with extracellular mucin- a new rare variant," Journal of Clinical and Diagnostic Research. 2015 Apr, Vol-9(4): ED05-ED06.
[5]. Yu et al., Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies Diagnostic Pathology 2010, 5:3.

Abstract:Inadequate posterior capsular support during cataract surgery makes it impossible to implant posterior chamber intraocular lens. Leaving the eye aphakic affects the quality of life as it causes high hypermetropia and anisometropia. In such conditions, secondary intraocular lens implantation options are sutured scleral fixation, intrascleral fixation, angle‐supported anterior chamber, and anterior chamber or retropupillary iris‐claw IOLs(1) Scleral sutured PCIOL are anatomically closer to the original IOL resulting in good visual outcome but they are technically difficult to insert and passing scleral needle passes increase the risk of intraocularhemorrhage, suture breakage and endophthalmitis.

[1]. Dick HB, Augustin AJ. Lens implant selection with absence of capsular support. Curr Opin Ophthalmol. 2001;12(1):47-57.
[2]. Gonnermann J, Klamann MK, Maier AK, Rjasanow J, Joussen AM, Bertelmann E, et al. Visual outcome and complications after posterior iris-claw aphakicintraocular lens implantation. J Cataract Refract Surg. 2012;38(12):2139-43.
[3]. Rao R, Sasidharan A. Iris claw intraocular lens: a viable option in monocular surgical aphakia. Indian J Ophthalmol. 2013;61(2):74-5.
[4]. Baykara M, Ozcetin H, Yilmaz S, Timuçin OB. Posterior iris fixation of the iris-claw intraocular lens implantation through a scleral tunnel incision. Am J Ophthalmol. 2007;144(4):586-591.
[5]. Rao R, Sasidharan A. Iris claw intraocular lens: A viable option in monocular surgical aphakia. Indian J Ophthalmol 2013;61:74-5

Abstract:Dental Implants have been widely used for effective replacement of missing teeth with a greater survival rate for completely edentulous ,partially edentulous and single tooth restorations. There have been revolutionary changes with time in implants variable sizes, shapes, methods, positions of placements.A preoperative assessment holds an important role for evaluation of surrounding structures, vital nerves and vessels .Also the medical condition of the patient should be carefully determined. The prosthetic phase is precedeed by the assessment of emergence profile, angulation of implant and impact of occlusal forces on the implant.........

Keywords: Dental Implant, mandibular molar, missing molar replacement, Screw cement retained prosthesis. (SCRP)

[1]. Kumar NS, Sowmya N, Mehta DS, Kumar PS. Minimal guided bone regeneration procedure for immediate implant placement in the esthetic zone. Dent Res J. 2013;10 (1): 98-102.
[2]. Hudieb M, AL Khader M, Mortaja S, Abusamak M, Wakabayashi N, Kasugai S. Impact of bone augmentation of facial bone defect around Osseo integrated implant: a three-dimensional finite element analysis. Dent J 2021,9(10):114.
[3]. El Askary AS. Aesthetic considerations in anterior single tooth replacement. Implant Dent 1999; 8:61-67.
[4]. Spielman HP. Influence of the implant position on the aesthetics of the restoration. Pract Periodontics Aesthet Dent. 1996; 8:897-904.
[5]. Simeone P, De Paoli C, De Paoli S, Leofreddi G, Sgaro S. Interdisciplinary treatment planning for single-tooth J Esthet Restor Dent. 2007; 19(2): 79-88.

Abstract:Background: To assess the influential determinants of microbial colonization of oral cavity in term infants Materials and Methods: This study was approved by the ethics committee of the Faculty of Dentistry-Universidad Nacional Federico Villareal and was conducted at the Instituto Nacional Materno Perinatal (INMP), Lima-Peru in March 2022. The sample consisted of 30 full-term births and swabs on the palate and back of the tongue 4 and 8 hours after birth. Five culture media were used for reading and identifying microorganisms Results: Eutocic births were female (36.7%). The mothers of the neonates did not receive dental prophylaxis in the last 6 months (76.6%). 46.7% of eutocic births received Exclusive Breastfeeding and were suitable for gestational age (AEG) in 83.4%. Staphylococcus spp was present 4 and 8 hours after birth (p=0.273) and the rest of the microorganisms were absent (p=0.000).......

Keywords: term births, microbial colonization, oral cavity.

[1]. Aguirre, A., Gamarra, R. (2016). Nivel de colonización de Streptococcus mutans en cavidad oral de neonatos según vía de nacimiento. Oral Año 17. Núm. 53, 2016. 1341-1345. Recibido: Julio, 2015. Aceptado: Enero, 2016.
[2]. Arellano L. (2018). Microbiota Oral en Recién Nacidos por Parto Vaginal y Cesárea en el Hospital Regional Hermilio Valdizán Huánuco 2018. Sunedu.gob.pe. https://doi.org/http://repositorio.udh.edu.pe/123456789/2099
[3]. Cunningham FG, Leveno KJ, Bloom SL, Spong CY, Dashe JS, Hoffman BL, et al. (2015). Williams Obstetricia. 24 ed. México: McGRAW-HILL Interamericana Editores, SA; 1356 p.
[4]. Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010). Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns.
[5]. Proceedings of the National Academy of Sciences, 107(26), 11971–11975. https://doi.org/10.1073/pnas.1002601107

Abstract: Background: Posture Is The Alignment And Maintenance Of Body Segments In Certain Positions Such As Standing, Lying Or Sitting. Postural Kyphosis Is Caused By The Adaptation Of Wrong Posture. Postural Kyphosis Usually Starts To Show Up In Adolescents With More Females Being Affected Compared To Males. Kyphosis Which Occurs To Compensate The Breast Development In Girls After Puberty Due To Carrying Heavy School Bags, Wrong Posture. Occiput Wall Distance Test Is The Type Of Outcome Measure The Severity Of The Kyphotic Curve. The Present Study Is About Effect Of Anti-Gravity Exercises With Or Without Schroth Therapy On Postural Kyphosis Among Female Adolescents.........

Keywords: Anti-gravity exercise, Schroth remedy, Posture, Occiput wall distance test.

[1]. Hanfy, Hala M et al..,: effect of exercise on postural kyphosis in female after puberty- Indian journal of physiotherapy and occupational therapy. Jul-sept2012, vol 6.
[2]. Katzman W et al.., : age-related hyperkyphosis: update of its potential causes and clinical impacts-narrative review. Aging clin exp res. 2017 aug;29(4):567-577. [Pubmed: 27538834]
[3]. Lam JC,MukhdomiT et al..,: kyphosis. 2022 Jan 15 In: statpearls publishing;2022 Jan.
[4]. Drzal-Grabiec J et al.., : changes in the body posture of women occurring with age. BMC geriatr. 2013 oct 12;13: 108.
[5]. Feng Q, Wang M et al.., : A corrective functional exercise program for postural thoracic kyphosis in teenagers: a randomized controlled trial. Clin Rehabil. 2018 Jan;32(1): 48-56. Jun 14.

Abstract: Introduction: Multi Kinase Inhibitors (MKI) like Sorafenib, Lenvatinib are a group of drugs used in the treatment of patients with Hepatocellular carcinoma (HCC), advanced renal cell carcinoma, thyroid malignancies. The main mechanism of action consists of inhibition of Vascular endothelial growth factor receptors (VEGFRs), Fibroblast growth factor receptors, KIT, Platelet derived growth factor receptors (PDGF), RET.

Keywords: Lenvatinib, Sorafenib, kinase inhibitors, Cutaneous drug reaction, HCC.

[1]. Wilhelm SM, Adnane L, Newell P, Villanueva A, Llovet JM, Lynch M. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther. 2008-3129-40. [2]. Padda IS, Parmar M. Lenvatinib. [Updated 2022 Jul 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK567768/ [3]. Cohen PR. Sorafenib-associated facial acneiform eruption. Dermatol Ther (Heidelb). 2015:77-86. [4]. Kwakman JJM, Elshot YS, Punt CJA, Koopman M. Management of cytotoxic chemotherapy-induced hand-foot syndrome. Oncol Rev. 2020-14(1):442. [5]. Kim DH, Son IP, Lee JW, Lee HI, Kim BJ, Kim MN. Sorafenib (Nexavar®, BAY 43-9006)-induced Hand-foot Skin Reaction with Facial Erythema. Ann Dermatol. 2011:119-22.

Abstract:Introduction: Geriatric hip fracture is a common type of osteoporotic fracture with high mortality and disability;Surgical site infection (SSI) can be a devastating complication of this injury. By far, only a few studies identified easily remediable factors to reduce infection rates following hip fracture and less researches have focused on geriatric patients. The objective of this study was to identify risk factors and potentially modifiable factors associated with SSI following geriatric hip fracture surgery. Objectives:The aim of the study is to identify the risk factors associated with surgical site infection in hip fracture surgeries among geriatric population in a tertiary care centre........

Keywords: Surgical site infection; implant related infection; orthopaedic infection; ,hip fracture surgeries; risk factors;, biofilms.

[1]. CAMPBELL‟S operative orthopaedics, 13th edition, volume 1, chapter 21. 771- 779.
[2]. ROCKWOOD AND GREEN‟S FRACTURES IN ADULTS , eighth edition
[3]. ,section1 chapter 26 , 793-818
[4]. JadrankaMaksimovic, LjiljanaMarkovic-Denic, Marko Bumbasirevic,
[5]. JelenaMarinkovic, HristinaVlajinac. Surgical Site Infections in Orthopedic Patients:

Abstract:Purpose: The aim of this meta-analysis is to assess the effectiveness and outcomes of laparoscopic pylorus preserving gastrectomy (LPPG) and laparoscopic distal gastrectomy (LDG) in patient with early gastric cancer (EGC). Methods: Renowned databases such PubMed, Google scholar and Medline were searched from the year 2004 to 2023.Postoperative outcomes recorded were operation time, blood loss, hospital length of stay, lymph node dissection, anastomotic leakage, gastric emptying, gastric stasis, wound infection and ileus. All included studies were analyzed by Review manager software 5.4 (RevMan).......

[1]. Jemal, A., et al., Global cancer statistics. CA: a cancer journal for clinicians, 2011. 61(2): p. 69-90.
[2]. Association, J.G.C., Japanese classification of gastric carcinoma–2nd English edition–. Gastric cancer, 1998. 1: p. 10-24.
[3]. Shi, Y. and Y. Zhou, The role of surgery in the treatment of gastric cancer. Journal of surgical oncology, 010. 101(8): p. 687-692.
[4]. Kim, H.S., et al., Analysis of predictive risk factors for postoperative complications of laparoscopy-assisted distal gastrectomy. Journal of Laparoendoscopic & Advanced Surgical Techniques, 2013. 23(5): p. 425-430.
[5]. Xia, X., et al., Objective evaluation of clinical outcomes of laparoscopy-assisted pylorus-preserving gastrectomy for middle-third early gastric cancer. BMC Cancer, 2019. 19(1): p. 481.

Abstract: Background: Endoscopic retrograde cholangiopancreatography (ERCP) is an invasive procedure and produces substantial discomfort to the patient. Conscious sedation is preferred for sedation in ERCP. Most commonly used drug for conscious sedation is propofol. Different adjuvants are also used with propofol as premedication like midazolam, fentanyl, remifentanil, dexmedetomidine etc. Objective: The aim of the study was to evaluate the effectiveness of dexmedetomidine and midazolam as premedication for sedation in patients undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP). Methods: This Randomized.......

Keywords: Conscious sedation, Dexmedetomidine, Midazolam, Propofol, ERCP

[1]. Hassan HI. Dexmedetomidine versus ketofol for moderate sedation in Endoscopic Retrograde Cholangiopancreatography (ERCP) comparative study. Egyptian Journal of Anaesthesia. 2015 Jan 1;31(1):15-21.
[2]. Gorji FB, Amri P, Shokri J, Alereza H, Bijani A. Sedative and analgesic effects of propofol-fentanyl versus propofol-ketamine during endoscopic retrograde cholangiopancreatography: a double-blind randomized clinical trial. Anesthesiology and pain medicine. 2016 Oct;6(5).
[3]. Lichtenstein DR, Jagannath S, Baron TH, Anderson MA, Banerjee S, Dominitz JA, Fanelli RD, Gan SI, Harrison ME, Ikenberry SO, Shen B. RETRACTED: Sedation and anesthesia in GI endoscopy. Gastrointestinal endoscopy. 2008 Aug 1;68(2):205-16.
[4]. Sethi P, Mohammed S, Bhatia PK, Gupta N. Dexmedetomidine versus midazolam for conscious sedation in endoscopic retrograde cholangiopancreatography: An open-label randomised controlled trial. Indian journal of anaesthesia. 2014 Jan;58(1):18.
[5]. Angsuwatcharakon P, Rerknimitr R, Ridtitid W, Kongkam P, Poonyathawon S, Ponauthai Y, Sumdin S, Kullavanijaya P. Cocktail sedation containing propofol versus conventional sedation for ERCP: a prospective, randomized controlled study. BMC anesthesiology. 2012 Dec; 12:1-7.