Abstract: Bioaccumulation of herbicides is a potential hazard for man and animals. In a previous study conducted by our team of researchers, leaves from experimental beans that were treated with butachlor® at pre-emergent were found to have bioaccumulated residues of the herbicide at 6 weeks. The control beans without exposure to herbicide had no trace of butachlor® detected in the leaves but the test beans which were treated with 260mg/m2 (recommended concentration) had 0.10 ppm while 290 and 320 mg/m2 induced a correspondingly increased bioaccumulation value of 0.13 and 0.20ppm. Sub-chronic (28-day) exposure through feeding of experimental rabbits with bean forages containing the different concentrations of the bioaccumulatedbutachlor® was then conducted..........
Keywords: Herbicide, Bioaccumulation, Butachlor®, Hepatotoxicity, Lesions
[1]. G. Allinson, and M. Morita, Bioaccumulation and toxic effects of elevated levels of 3,3′,4,4′-tetrachloroazobenzene (33′44′-TCAB) towards aquatic organisms,in A simple method for the rapid extraction, detection and determination of 33′44′TCAB in multiple biological samples,Chemosphere, 30 (2), 1995, 215-221.
[2]. J.Fenik,M. Tankiewicz, and M.Biziuk, Properties and Determination of Pesticides in fruits and vegetables,Trends in Analytical Chemistry, 30 (6), 2011, 814-824.
[3]. W.F. Heydens, I.C. Lamb, and A.G. Wilson, Chloracetanilides, in Krieger, R. (Ed.), Handbook of Pesticide Toxicology,(San Diego: Academic Press, 2002) 1543–1558.
[4]. D.J.Ecobichon, Toxic effects of pesticides,inKlaassen, C.P. (Ed.), Casarett and Doull's Toxicology, The Basic Science of Poisons, (New York: Mc-Graw-Hill Medical Publ. Division, 2001) 794–795.
[5]. M.Zimmermann, Ethical guidelines for investigation of experimental pain in conscious animals, Pain 16, 1983, 109-110.