Series-2 (July-August 2019)July-August 2019 Issue Statistics
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| Paper Type | : | Research Paper |
| Title | : | Evaluation of Intravenous Iron Sucrose Therapy for Iron Deficiency Anaemia in Pregnancy |
| Country | : | India |
| Authors | : | CH.Sri Devi || K. Sai Ram || L. Divya Vani || K. Praneetha || Lubna Jabeen |
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: | 10.9790/3008-1404020106  |
Abstract: Iron deficiency anaemia (IDA) is the most common nutritional deficiency in pregnancy. Prophylactic oral iron is recommended during pregnancy to meet the increased requirement. In India, women become pregnant with low baseline haemoglobin levels resulting in high incidence of moderate to severe anaemia in pregnancy, where oral iron therapy cannot meet the requirement. Pregnant women with anaemia are to be treated with parenteral iron therapy. An Observational Prospective study was conducted to evaluate the safety and efficacy of IV Iron Sucrose therapy in the treatment of Iron Deficiency Anaemia. In this study two hundred pregnant women with.........
Key Words:Iron Deficiency Anaemia, Parenteral Iron Therapy, Iron Sucrose Complex, Pregnant women
[1]. Dutta Dc. Text book of obstetrics including perinatology & contraception. 6th ed.Calcutta: New Central Book Agency (P) Ltd; 2004. Anaemia in pregnancy; pp. 262–7.
[2]. Kalaivani K. Prevalence & consequences of anaemia in pregnancy. Indian J Med Res.2009; 130:627–33. [PubMed]
[3]. Iron-deficiency anemia. American Society of Hematology.http://www.hematology.org/Patients/Anemia/Iron-Deficiency.aspx. Accessed Oct. 16, 2016.
[4]. Seril DN, Liao J, Ho KL, Warsi A, Yang CS, Yang GY. Dietary iron supplementation enhances DSS-induced colitis and associated colorectal carcinoma development in mice. -Dig Dis Sci. 2002; 47(6):1266–1278. [PubMed].
[5]. Koutroubakis IE, Oustamanolakis P, Karakoidas C, Mantzaris GJ, KouroumalisEASafety and efficacy of total-dose infusion of low molecular weight iron dextran for iron deficiency anemia in patients with inflammatory bowel disease. Dig Dis Sci. 2010; 55(8):2327–2331. [PubMed].
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| Paper Type | : | Research Paper |
| Title | : | Development and Evaluation of Fast Dissolving Furosemide Tablet |
| Country | : | India |
| Authors | : | SandeepA.Wathore || V.M.Kale YuvrajL.Pandhare || Sandesh R. Sul |
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: | 10.9790/3008-1404020717 |
Abstract: Problems of swallowing and provides a quicker onset of action overcomes by fast dissolving tablets constitute an innovative excipients. The bioavailability of some drugs may be increased due to absorption of drugs in oral cavity. Fast dissolving tablets of Furosemide, prepared by sublimation method using camphor as subliming agent and croscarmellose sodium, sodium starch glycolate and cross povidone as a super disintegrates by direct compression method. FTIR Spectroscopy was carried out to determine the suitability of superdisintegrates with the drug. The prepared fast dissolving tablets of Furosemide, were evaluated for post compression parameters. Optimum formulation of Croscarmellose sodium S3 showed disintegration time of 9 seconds and 97.07% of drug release..
Key words: Mouth dissolving tablet, Sublimation technique, Furosemide, Subliming agent, Superdisintegrates
[1]. Sameer LG, Yi-Ying Y, Ajay K. Effect of disintegration- promoting agent, lubricants and moisture treatment on optimized fast disintegrating agent. Int. J. Pharm, 2008, 1-8.
[2]. Abdelbary G, Prinderre P, Eouani C, Joachim J, Reynier, JP. The preparation of orally disintegrating tablets using a hydrophilic waxy binder. Int. J. Pharm, 2004, 423-433.
[3]. Alai K, Rote HR, Sonawane SH, Thakare VM, Tekade BW, Patil VR. Formulation and Development of Aceclofenac Fast Dissolving Tablet: Subliming Agents. Int. J. Pharm. Res. Dev, 4, 2012, 80 -84.
[4]. British Pharmacopoeia, Medicine and Healthcare Product Regulatory Agency (MHRA), sixth ed, British Pharmacopoeia Commission Office, London. 2009, II, 5872-5877.
[5]. Pavia DL, Lampman GM, Kriz GS. Introduction to Spectroscopy. Third edition, Indian ed, 2007, 26-27..
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| Paper Type | : | Research Paper |
| Title | : | Newer Approches of the Ocular Drug Delivery System: An Overview |
| Country | : | India |
| Authors | : | Aakashsinh vaghela || Dr.Pragneshpatni |
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: | 10.9790/3008-1404021821 |
Abstract: Ideal ophthalmic drug delivery is one of the most interesting and challenging problem facing the pharmaceutical companies in the market .and the major problem associated with the conventional dosage forms is the bioavailability of drug. The Poor bioavailability of ophthalmic solutions caused by dilution and drainage from the eye can be overcome by using in-situ-forming ophthalmic drug delivery systems. To overcome these problems various types of dosage forms such as nanoparticles, liposomes and microemulsions have been developed.Controlleddrugdelivery systems offer many advantages overconventionaldosage forms interms of improving drug bioavailability, reducing toxicity and decreasing.......
Key words: Ocular drug delivery, eye drug delivery,nanotechnology, Nano- formulation, Ocular Disorder,punctum plugs.
[1]. Wolff, E: Anatomy of eye and orbit. Blakistone Company, New York and Toronto, 4th edition, 1954:207.
[2]. K. P. Sampath Kumar, Debit Bhowmik, G. Harish, S. Duraivel, B. Pragathi Kumar: Ocular Inserts: A Novel Controlled Drug Delivery System. The pharma innovation journal 2013; 1(12): 1-16.
[3]. VHL Lee: New directions in the optimization of ocular drug delivery. Journal ofOculPharmakon 1990; 6:157–164.
[4]. Kaur IP, Kanwar M: Ocular preparations: The formulation approach. Drug developmentIndustrial Pharmacy 2002; 28(5):473-493.
[5]. VHL Lee, JR Robinson. Review: Topical drug delivery: recent developments and future challenges. Journal Oculus Pharmakon. 1986; 2:67–108.
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| Paper Type | : | Research Paper |
| Title | : | Recent Advanced Approaches in Pulmonary Drug Delivery System: A Review |
| Country | : | India |
| Authors | : | Harshrahsinh Rana || Dr. Pragnesh Patani |
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: | 10.9790/3008-1404022227 |
Abstract: The lung has served as a route of drug administration for thousands of year. Now a day's pulmonary drug delivery remains the preferred route for administration of various drugs. Pulmonary route have been used to treat various respiratory diseases for centuries. Ancient inhalation therapies included the use of leaves from plants vapors from aromatic plant, balsam and myrrh. The pulmonary route has gained increasing importance in the recent time due to its unique properties such as a large absorptive area of up to 100m2; extremely thin 0.1μm to 0.2μm absorptive mucosal membrane and good blood supply. Pulmonary drug delivery is an important research area which impacts the.........
Key Words: pulmonary drug delivery, lungs, aerosol, dry powder inhaler, meter dose inhaler, nebulizer, fine particle fraction
[1]. Kohler.D.aerolizedheparin, journal of aerosols medicine.1994; 7(4):307-314.
[2]. Martin.R.J. boguniewicz, m; Henson, J.E.the effect of inhaled interferon gamma in normal human airway, required of respiratory disease, 1993; 148:1677-1682.
[3]. Everard.M.L.; devadason, s. g.:summer,Q.A.le souef, p.n. factor affecting total and respirable dose by salbutamol metered dose inhaler thorax, 1995; 746-749.
[4]. Patton.J.S.mechanism of macromolecule absorption by the lung; adv. Drug delivery review. 1996-3-36.
[5]. Akwete.A.L.gupta;eds;niven delivery of bio therapeutic by inhalation aerosol; inhalation delivery of therapeutic peptide and protein; macrodekker,inc,new york,1997,157-231..
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| Paper Type | : | Research Paper |
| Title | : | Interferon Alpha In Eye Drops For Conjunctivalcarcinoma In Situ |
| Country | : | Maroc |
| Authors | : | Maryama El Kaddoumi || OuafaCherkaoui |
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: | 10.9790/3008-1404022829 |
Abstract: Squamous cell carcinoma of the conjunctiva is a rare, malignant epithelial tumor that usually affects the elderly. The purpose is to recall the importance of histological examination before any suspicious lesion in the diagnosis, therapy and prognosis as well as the interest of topical chemotherapy in the prevention of recurrence.
Key Words: Interferon alpha,conjunctiva,carcinoma in situ
[1]. S. Bouzza, et.alRevue Marocaine du Cancer 2011, vol. 3, n°4 : 20-25
[2]. O Lumbro – C Le Rou N°112 - Tome 13 - février 2008 - RéfleXions Ophtalmologiques
[3]. D de Wolff-Rouendaal, J Sahel EMC Ophtalmologie, 21-150-A-10, 2000, 22 p.
[4]. Kim JW, Abramson DH. Topicaltreatment options for conjunctivalneoplasms. Clin Ophthalmol 2008 ; 2 : 503-15.
[5]. Rozenman Y, Frucht-Pery J. Treatment of conjunctivalintraepithelialneoplasiawithtopical drops of mitomycin C. Cornea 2000 ; 19 : 1-6.
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| Paper Type | : | Research Paper |
| Title | : | Preparation of Dacarbazine Lipid Nanocapsule Based Hydrogel as an Efficient Delivery System for Melanoma |
| Country | : | Egypt |
| Authors | : | Hend Mohamed Abdel-Bar |
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: | 10.9790/3008-1404023035 |
Abstract: Although dacarbazine is the gold therapy for melanoma, its systemic use is usually associated with many limitations. These include poor aqueous solubility, short half-life and toxicity. Herein, we explored the potential of lipid nanocapsule (LNC) based hydrogel as an efficient nanocarrier for transdermal delivery of dacarbazine. The proposed system was fabricated in two consecutive steps firstly,dacarbazine LNC was prepared using labrafac and solutol HS15 in different ratios and characterized regarding the particle size, zeta, entrapment efficiency(EE %) and morphological......
Key Words: cytotoxicity, dacarbazine, hydrogel, lipid nanocapsule, melanoma
[1]. Mishra H, Mishra PK, Iqbal Z, Jaggi M, Madaan A, Bhuyan K, Gupta N, Gupta N, Vats K, Verma R, Talegaonkar S. Co-Delivery of Eugenol and Dacarbazine by Hyaluronic Acid-Coated Liposomes for Targeted Inhibition of Survivin in Treatment of Resistant Metastatic Melanoma. Pharmaceutics,11, 2019, pii: E163.
[2]. Baharara J, Amini E, Nikdel N, Salek-Abdollahi F. The Cytotoxicity of Dacarbazine Potentiated by Sea Cucumber Saponin in Resistant B16F10 Melanoma Cells through Apoptosis Induction. Avicenna J Med Biotechnol. 8, 2016, 112-9.
[3]. DominguesB, LopesJM, SoaresP, PópuloH. Melanoma treatment in review. Immunotargets Ther. 7, 2018, 35–49.
[4]. HafeezA, KazmiI. Dacarbazine nanoparticle topical delivery system for the treatment of melanoma. Sci Rep. 7, 2017, 16517.
[5]. VarshosazJ, HajhashemiV, SoltanzadehS. Lipid Nanocapsule-Based Gels for Enhancement of Transdermal Delivery of Ketorolac Tromethamine. Journal of Drug Delivery. Article ID 571272, 2011
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| Paper Type | : | Research Paper |
| Title | : | Prenatal Dexamethasone Exposure Malfunctions Maternal Outcome of Albino Rats |
| Country | : | Kenya |
| Authors | : | Ndung'u C. Wangui || Kweri J. Kariuki || Thuo Reuben || Kafaya G. Kibe |
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: | 10.9790/3008-1404023648 |
Abstract: Background information:The normal morphogenesis of maternal body has been shown to be disrupted by the prenatal exposure to dexamethasone when used during pregnancy, however the specific effects of varied doses of dexamethasone on various organs at different gestion period have not been refined. Such perturbation has been shown to interfere with the normal structural and metabolic function such a in secretion of digestive juices as well as control of the glucose metabolism, neurobehavior abnormalities and gross impairments of functional organs such as pancreas, kidneys, skeletal muscles, adrenal gland, thymus gland, spleen and adipose tissue. Corticosteroids also have........
Key Words:glucorticoids, dexamethasone, prenatal
[1]. Training AN, Training AN, Training AN. Özgün Çalışma / Original Article THE EFFECT OF DEXAMETHASONE TREATMENT ON MATERNAL OUTCOME IN HELLP SYNDROME HELLP SENDROMUNDA DEKSAMETAZON TEDAVİSİNİN MATERNAL SONUÇLAR. 2019:8-12.
[2]. Objectives A. The WHO ACTION-II ( Antenatal CorticosTeroids for Improving Outcomes in preterm Newborns ) Trial. 2016.
[3]. Pang S, Clark AT, Freeman LC, et al. Maternal side effects of prenatal dexamethasone therapy for fetal congenital adrenal
[4]. Meyer-bahlburg HFL, Dolezal C, Haggerty R, Silverman M, New MI. Cognitive outcome of offspring from dexamethasone-treated pregnancies at risk for congenital adrenal hyperplasia due to 21-hydroxylase deficiency. 2012:103-110. doi:10.1530/EJE-11-0789
[5]. Meneguel JF, Guinsburg R, Miyoshi MH, et al. Antenatal treatment with corticosteroids for preterm neonates: impact on the incidence of respiratory distress syndrome and intra-hospital mortality. Sao Paulo Med J. 2003;121(2):45-52. doi:10.1590/S1516-31802003000200003
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| Paper Type | : | Research Paper |
| Title | : | Comparative Study on Extraction Isolation and Phytochemical Screening of Leaves and Stems of Euphorbia Heterophylla with Their In-Vitro Antioxidant Potential |
| Country | : | India |
| Authors | : | Gulbahar || Amit Joshi |
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: | 10.9790/3008-1404024957 |
Abstract: In recent years, the search for biologically active compounds from Euphorbia heterophylla in the treatment of different diseases has always been of great interest to researchers. In this present study, we investigated the effect of the aqueous leaf and stem extract of euphorbia heterophylla. Phytochemical studies revealed the presence of tannins, anthraquinones, alkaloids, flavonoids and phenols in hexane, acetone and water extracts containing only phenol.The plant extracts demonstrated antimicrobial activity against both the test bacteria and fungi with water extract demonstrating the highest activity followed by the acetone extract. The plant has been presented for further isolation, identification and purification of these phyto-constituents. The result of the study showed that the crude plant material contained some secondary metabolites such as saponins, flavonoids and tannins. The phytochemical.........
Key Words: Euphorbia heterophylla, euphorbiaceae, Phytochemicals, In vitro antioxidant activity, leaf extract, stem extract.
[1] Abu, S., Ali. M., Bhattacharjee, M.A, P.K, Islam , Istaq A, Khan , G.R.M and Yeasmin , S (2005). Biological evaluation of extracts and triterpenoids of E.hirta. Pakistan J. Sci.Industrial res. 48: 122-125.
[2] Alupului A., 2012, Microwave ext ract ion of act ive principles fro mmedicinal plants. U.P.B. Science Bullet in, Series B 74(2)
[3] Amita P., and Shalini T., 2014, Concept of standardizat ion, extraction and pre Phytochemical screening st rategies for herbal drug, Journal of Pharmacognosy and Phytochemist ry 2 (5): 115-119
[4] Anees A., Abbas F., Alkarkhi M., Sufia H., Bazlul M., and Khoo W., and Dur ,2010,Optimization of Soxhlet Extraction of Herba Leonuri Using Factorial design of experiment. International journal of chemist ry.2 (1) 198-205
[5] Ankit G., Madhu N., and Vijay K., 2012, Modern extraction methods for preparation of bioactive plant extracts. Internat ional journal of applied and natural sciences (ijans) vol.1, issue 1 aug 2012 8-26.
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| Paper Type | : | Research Paper |
| Title | : | Effectiveness of Carbapenems in Hospital Acquired Pneumonia and Ventilator Associated Pneumonia against Extended Spectrum β-lactamases Enzyme producing Enterobacteriaceae in a Tertiary Care Hospital |
| Country | : | India |
| Authors | : | Afreen Naz || Sabha Sultana || Sadiqa Begum || Mr Mirza Misba Ali Baig || Syed Mahmood |
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: | 10.9790/3008-1404025872 |
Abstract: Background: This study aims to find out the prevalence of HAP/VAP, risk factors implicated, organisms involved and their sensitivity patterns. This study was designed to improve morbidity and reduce the hospital stay. Objective: The aim was to describe clinical response and microbiologic cure rates associated with carbapenems as first line treatment for infections caused by ESBL-producing organisms. Methodology: A prospective cohort observational open labelled study was conducted at Owaisi Hospital and Research Center, for patients admitted in the Department of Pulmonology for a period of six months. The demographic data, diagnostic criteria, associated risk factors and laboratory data including culture and antimicrobial susceptibility were collected........
Key Words:ESBL organisms, HAP, VAP
[1]. Harrisons "Principles Of Internal Medicine", Editors Dennis L .Kasper , Anthony S.Fauci, Stephen L.Hauser , Dan l. Longo , J .Larry Jameson, Joseph Loscalzo. 19th Edition. (2015)
[2]. Harsh Mohan " Text Book Of Pathology ", Editors Praveen Mohan, Tanya Mohan, Sugandha Mohan. 6th Edition. (2010).
[3]. Mahul P, Auboyer C, Jospe R, et al. "Prevention of nosocomial pneumonia in intubated patients: respective role of mechanical subglottic secretions and stress ulcer prophylaxis". Intensive Care Med 1992;18:20–5.
[4]. Guideline Kalil AC, Metersky ML, Klompas M, Muscedere J, Sweeney DA, Palmer LB, et al. "Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society". Clin Infect Dis. 2016 Jul 14.
[5]. Harsh Mohan " Text Book Of Pathology", Editors Praveen Mohan, Tanya Mohan, Sugandha Mohan. 6th Edition..
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| Paper Type | : | Research Paper |
| Title | : | Extraction Isolation and Phytochemical Screening of Leaves and Stems Of Bidens Pilosa and Evaluation of Antifungal Potential of Extracts |
| Country | : | India |
| Authors | : | Gulfsha Parveen || Mahtab Ali |
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: | 10.9790/3008-1404027385 |
Abstract: Bidens pilosa is a representative perennial herb, globally distributed across temperate and tropical regions. B. pilosa has been traditionally used in foods and medicines without obvious adverse effects. Despite significant progress in phytochemical and biological analyses of B. pilosa over the past few years, comprehensive and critical reviews of this plant are anachronistic or relatively limited in scope. The present review aims to summarize up-to-date information on the phytochemistry, pharmacology, and toxicology of B. pilosa from the literature. B. pilosa is a major crop weed, threat to native fauna, and a physical nuisance. It is considered one of the most noxious........
Key Words: Biden Pilosa, antifungal activity, essential oil, flavonoids, terpenes, treatment.
[1]. Karis, P.O.; Ryding, O. Asteraceae: Cladistics and Classification; Bremer, K., Ed.; Tember Press: Portland, OR, USA, 1994; pp. 559-569.
[2]. Bohlmann, F.; Burkhardt, T.; Zdero, C. Naturally Occurring Acetylenes; Academic Press: New York, NY, USA, 1973; pp. 356-359.
[3]. McCormick, S.P.; Bohm, B.A.; Ganders, F.R. Methylated chalcones from Bidens torta. Phytochemistry 1984, 23, 2400-2401.
[4]. Christensen, L.P.; Lam, J. Acetylenes and related compounds in Heliantheae. Phytochemistry 1991, 30, 11-49.
[5]. Jensen, S.L.; Sörensen, N.A. Studies related to naturally occurring acetylene compounds. XXIX. Preliminary investigations in the genus Bidens. I. Bidens radiate and Bidens ferulaefolia. Acta Chem. Scand. 1961, 15, 1885-1891..