iosr-JPBS   Volume-15 ~ Issue-3 ~ May-June 2020

Abstract: RESUME Les adénomes pituitaires ou 'non secrétant' sont rarement associés à une hypersécrétion hormonale. Leur association avec une hyperlipidémie se fait encore plus rare. Le but de ce travail est de déterminer le profil biologique de ces adénomes tout en soulignant la probabilité de survenue d'une hyperlipidémie appariée. Observation: Il s'agit d'une patiente âgée de 68 ans, hypertendue, diabétique de type 2 sous insuline, suivie depuis 5 ans pour hyperthyroïdie sur goitre hétéro multi nodulaire (GMHN) toxique. La patiente a été admise au service d'endocrinologie au centre hospitalier universitaire (CHU) Hassan II de Fès suite à une perturbation métabolique découverte après un malaise.L'examen clinique ne retrouve pas d'anomalies. Cependant devant les épisodes de céphalées, vertiges et brouillard

Keywords: hyperlipidémie majeure; macro adénome hypophysaire; non sécrétant; sérum opalescent

Abstract: Background :Traditional medicine in orthopedic traumatology retains an important place in our country, it is closely linked to the socio-cultural universe and deeply rooted in societal habits. This traditional medicine is responsible for serious complications. Case Report :It is about a 24-year-old student, with morbidity, having as antecedent trauma left forearm by crushing treated by traditional treatment "Jbira" (Poultice) in early childhood. Concave deformation of the forearm, with amyotrophy and no functional repercussion. Result :The latissimus dorsi free flap wase chosen with a good result. Conclusion :Integrating traditional medicine into the national health care system is difficult, but it is important to educate these "Jebbars" about the risks of their practices..

Key Words : Poultice Free flap, Latissumus Dorsi, Microsurgery

Abstract: Kuru, a very rare fatal neurodegenerative disease. It mainly affects the cerebellar region of the brain. It is caused by infectious proteins called prions. These prions are a deviant form of harmless protein. Kuru is a transmissible spongiform encephalopathy, prion disease. It is a human prion disease. The symptoms include tremors, loss of coordination, depression, muscle spasms and behavioural changes and ultimately lead to death. The incubation period of this disease varies from person to person and it could be as short as 5years and could be as long as 50 years. It is most prevalently seen in Papua New Guinea where a ritual of cannibalism is practiced, where most of the elderly women and children are affected as they are the one to whom human brain is given to consume during cannibalism. The....

Keywords: kuru, neurodegenerative disease, prions, transmissible spongiform encephalopathy, tremors, cannibalism, biopsy

Abstract: Introduction: Drug use evaluation is a method of obtaining information to identify problems related to drug use and if properly developed, it also provides a means of correcting the problem and thereby contributes to rational drug therapy. The aim of this study wasto evaluate drug use based on WHO prescribing indicators in private clinics WoliataSodocity, Southern Ethiopia. Methods: A cross sectional study was carried out inWolaitaSodo City private clinics from March 1 – May 30, 2017. Patients' medical records from March 2016 to Feb2017were reviewed for evaluation of WHO prescribing indicators. Total of 720 patient medical records were reviewed. Systematic random sampling was used after clustering health facility for patient load.Statistical Package for Social Sciences (SPSS) version-24 software was used for data management......

Key words:Drug use evaluation, private Clinic, Sodo

Abstract: Background: Irrational prescription of drugs is a common occurrence especially in the developing countries. Regular monitoring of drug utilization pattern promotes the rational use of drugs. The objective of the present study was to assess the prescribing pattern and drug use in ophthalmology in Dhaka, Bangladesh and to evaluate its rationality with WHO core drug prescribing indicators and other parameters. Methods:A retrospective study was conducted for two months on ophthalmology outpatient department in four hospitals of Dhaka city. Data was obtained from a total of 307 prescriptions and descriptive statistics was used in summarizing the results. Results:The study revealed....

Key words: prescribing pattern, drug use, ophthalmology, WHO core drug prescribing indicators, Fixed Dose Combination, polypharmacy

Abstract: Environmental conditions and processed foods which inhibit growth of probiotic bacteria and antimicrobial substances may cause alterations in human microbiota, which can lead to various diseases. Probiotics are live microorganisms that recover indiviual health and are usefull in alleviating post-antibiotic treatment syndromes. Probiotic bacteria can be ingested by consuming fermented food products, as well as probiotic treatment. Majority of the market based probiotics contain lactic acid baceria such as lactobacilli, streptococci, and bifidobacterial, due to them being a crucial component of the gastrointestinal microbiota. Bacterial strain of B. coagulans MTCC 5260, obtained from the commercially available probiotic Prolife was used to test the effect of subinhibitory....

Key Word: probiotics; antibiotics; Lactobacilli; biofilm; MIC

Abstract: Pharmacognostic investigation of fresh, powdered and anatomical sections of leaf, stem and root of Persea americana Mill (Lauraceae), were carried out to determine its macroscopic, microscopic, chemomicroscopical features as well as the physicochemical and phytochemical profile. The macromorphological parts showed alternate, simple and broad with a lanceolate – oblong shape, swollen petiole at the base, margin is entire, slightly undulated and waxy, apex is acuminate with an acute leaf base. The leaf is glossy, pubescent and dark green with a slightly disagreeable smell. The stem has a hard texture, rough fracture, superficially cracked or inconspicuously fissured and peels off in thick pieces with a disagreeable smell. The root has a long.....

Keywords: Persea americana, Pharmacognostic analysis, Macroscopy, Chemomicroscopy, Analytical standards

Abstract: The antioxidant activity of lumichrome and its derivative (its reduced form) namely 5,10- dihydro-7,8-dimethyl alloxazine which was synthesized from lumichrome were investigated. Both compounds were found to be active but the IC50 value of lumichrome was found to be even better than that of the standard ascorbic acid. This finding aptly reflects that further research could be carried out on lumichrome (7,8-dimethyl alloxazine) for development as a new potential antioxidant drug for treating the pathological states caused by oxidative stress. List of keywords: Antioxidant, Free Radical, Lumichrome, DPPH Assay

Abstract: Chloroquine works on the coronavirus via multiple pathways. It predominantly inhibits the process of coronavirus endocytosis (importation into the cell). During endocytosis, the virus forms an envelope using the cell membrane of the host cell. This envelope containing the virus inside it is called an endosome. For the virus to reach its target, the endosome has to travel into the cell plasma, and then enters another subcellular organelle called lysosome. It exits the lysosome and then proceeds to its final destination within the cell, where viral multiplication and absolute tragedy occurs. Now when chloroquine is........

Abstract: Mosquitoes are generally divided intotwo main subfamilies: the Anophelinae and Culicinae. The study was conducted between September 2015 and August 2017 to investigate Culicine species distributions in Taraba state, Nigeria. Indoor mosquitoes in Ardo Kola, Bali and Donga were collected using Spread Sheet Collection method. 1110 Culicine mosquitoes were identified to 9 species level: Culexpipiens 373 (33.6%), Culexpilosus 266 (24.0%), Culexquinquefasciatus 250 (22.5%), were major species. 8 species collected from Ardo Kola79 (7.1%) were dominated by Culexpipiens20 (5.4%). Bali had 428 (38.6%) composed of 7 species, dominated by Culexquinquefasciatus 130 (52.0%). Donga had the highest 603 (54.3%) composed of 8 species, dominated by Culexpilosus 134 (50.4%) and were more abundant in wet season than dry season.Analysis of Variance showed significant differences in species distributions (P < 0.05). This means that the study area has a diverse culicine species.

Keywords: Culicine species, Seasonss, Guinea savanna, Nigeria