Abstract: A highly efficient, eco-friendly, and simple one-pot three-component synthesis of fused [1,2,4] triazoloquinazolinone derivatives has been developed utilizing sulphanilic acid (4-aminobenzenesulfonic acid) as an inexpensive, non-toxic, and readily available solid acid catalyst. The reaction involves the multicomponent condensation of 3-amino-1,2,4-triazole, substituted aromatic aldehydes, and dimedone (or 1,3-cyclohexanedione) under ethanol reflux conditions. Optimized reaction parameters (10 mol% sulphanilic acid in EtOH at 78°C) afforded the target heterocycles in high to excellent yields (88-96%) within significantly shortened reaction times.....
Keywords: Sulphanilic acid, Multicomponent reaction, One-pot synthesis, [1,2,4] Triazoloquinazolinones, Green chemistry, Solid acid catalyst
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