Series-1 (Sep. – Oct. 2025) Sep. – Oct. 2025 Issue Statistics
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| Paper Type | : | Research Paper |
| Title | : | Title |
| Country | : | |
| Authors | : | xxx |
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: | 10.9790/ 264X-1105010108  |
Abstract: The 21 st century witnessed an accelerating convergence of three paradigm shifting technologies: stem cell biology, genomic engineering and artificial intelligence. Although both disciplines are strong individually, the combination of the two disciplines is providing new possibilities in the medical field to an unfathomable degree. This paper will comment on this synergy by looking at how artificial intelligence (AI) is making CRISPR-Cas9 gene editing of stem cells more accurate and more effective. This is the highly potent duo that is transforming science fiction therapies into something that is tangible in their existence.
[1].
[Induced Pluripotent Stem Cells] Takahashi, K., & Yamanaka, S. (2006). Induction Of Pluripotent Stem Cells From Mouse Embryonic And Adult Fibroblast Cultures By Defined Factors. Cell, 126(4), 663–676.
[2].
[Foundational CRISPR-Cas9 Discovery] Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012). A Programmable Dual-RNA-Guided DNA Endonuclease In Adaptive Bacterial Immunity. Science, 337(6096), 816–821.
[3].
[CRISPR-Cas9 In Human Cells] Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., ... & Zhang, F. (2013). Multiplex Genome Engineering Using CRISPR/Cas Systems. Science, 339(6121), 819–823.
[4].
[AI For On-Target Grna Design - Deepcrispr] Chuai, G., Ma, H., Yan, J., Chen, M., Hong, N., Xue, D., ... & Wei, J. (2018). Deepcrispr: A Deep Learning-Based Model For The Prediction Of CRISPR/Cas9 Guide RNA Cleavage Efficiency. BMC Bioinformatics, 19(1), 1-12.
[5].
[AI For On-Target Grna Design - Azimuth] Doench, J. G., Fusi, N., Sullender, M., Hegde, M., Vaimozhang, E. W., Thompson, J. F., ... & Root, D. E. (2016). Optimized Sgrna Design To Maximize Activity And Minimize Off-Target Effects For Genetic Screens With CRISPR-Cas9. Nature Biotechnology, 34(2), 184–191.
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| Paper Type | : | Research Paper |
| Title | : | Biochemical And Haematological Effects Of Ethanol Leaf-Extract Of Cnidoscolus Aconitifolius In Testosterone Propionate-Induced Benign Prostate Hyperplasic Rats |
| Country | : | Nigeria |
| Authors | : | Valentine Osita Godwin Nwobodo || Udu Ama Ibiam || Charles Chiedozie Ndu || Obiajulu Christian Ezeigwe || Obasi Uche Orji || Adachukwu Lilian Chukwu || Blessing Ngozi Osita |
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: | 10.9790/ 264X-1105010920 |
Abstract: The study investigated the biochemical and hematological effects of the ethanol leaf extract of Cnidoscolus aconitifolius in testosterone propionate-induced benign prostate hyperplasia (BPH) rats. Thirty male albino rats were divided into six groups of 5 rats each. Group 1 received subcutaneous administration of 1 ml/kg body weight of olive oil and 1 ml/kg of distilled water orally. Groups 2 to 6 were induced with BPH through daily subcutaneous injection of 3 mg/kg testosterone propionate followed by oral administration of the extract. Group 2 received 1 ml/kg distilled water; Group 3 received.......
Keywords: Cnidoscolus aconitifolius, benign prostate hyperplasia, haematology, dihydrotestosterone, ethanol leaf-extract.
[1]. Ajiboye BO, Oyinloye BE, Agboinghale PE, Ojo OA. Cnidoscolus Aconitifolius (Mill.) I. M. Johnst Leaf Extract Prevents Oxidative Hepatic Injury And Improves Muscle Glucose Uptake Ex Vivo. Journal Of Food Biochemistry, (2019); 43(12): 1-8.
[2]. Atata JA, Ayoola TO, Ajadi AA, Adamu S, Olatunji AO, Biobaku KT. Anti-Anaemic Effect Of Ethanol Leaf Extract Of Cnidosculusaconitifolius On Cyclophosphomide-Induced Anemia In Rats. Journal Of Complementary And Integrative Medicine, (2020); 18(1): 87–92.
[3].
Atroshchenko MM, Shitikova AM, Krokhotina LV, Engalycheva MG, Dmitrieva MN. Effect Of Testosterone, Dihydrotestosterone, Estradiol And Cortisol On The Quality Of Fresh And Cryopreserved Stallion Sperm.Journal Of Experimental Biology And Agricultural Sciences, (2022); 10(3): 619 – 627.
[4]. Bautista-Robles V, Guerrero-Reyes G, Sánchez-Torres GI, Parada-Luna F, Barrios-Gutiérrez JJ, Vázquez-Cerero D, Keita H. Cnidoscolus Aconitifolius: Usosterapéuticos Y Propiedadesfitoquímicas. Revisión De La Literatura. Revista De La Facultad De Medicina, (2020); 68(3): 1-8.
[5]. Bhattacharjee P, Bhattacharyya D. Characterization Of The Aqueous Extract Of The Root Of Aristolochia Indica: Evaluation Of Its Traditional Use As An Antidote For Snake Bites. Journal Of Ethnopharmacology, (2013);145(1):220-226.
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| Paper Type | : | Research Paper |
| Title | : | Structure -Based Inhibitor Design Targeting IDH1-R132Q In Glioblastoma Using Drug Discover With Biopython |
| Country | : | India |
| Authors | : | Namit Narang || Uma Kumari || Avirup Dey || Adarsh Murali |
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: | 10.9790/ 264X-1105012136 |
Abstract: In order to find novel inhibitors that target the Isocitrate Dehydrogenase 1 R132Q mutant (IDH1-R132Q), a major oncogenic driver in secondary glioblastoma (GBM), this paper describes a Structure-Based Drug Design (SBDD) approach. We described the allosteric regulatory site using the high-resolution X-ray crystal structure (PDB: 8VHB), which was confirmed by strict quality metrics (ERRAT: 97.9%; PROCHECK: 91.4% preferred). The best binding.......
Keywords: SDBD, Biopython, IDH1-R132Q, Glioblastoma, Structure Analysis, Sequence Alignment.
[1].
Abou-Ghanem, A., Farooq,
[2].
O., Liew, M., & Zein, A. (2023). Looking Beyond The Surface: Olutasidenib And Ivosidenib For The Treatment Of Mutant Idh1 Aml. Pharmacists’ Applications To Practice, 13(1), 12–16.
[3].
Berman, H. M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T. N., Weissig, H., Shindyalov, I. N., & Bourne, P. E. (2000). The Protein Data Bank. Nucleic Acids Research, 28(1), 235–242. Https://Doi.Org/10.1093/Nar/28.1.235
[4].
Clinicaltrials.Gov. (2023). A Phase 1 Study Of Ds-1001b In Patients With Recurrent Or Progressive Idh1-Mutant Gliomas (Nct05303519). National Library Of Medicine (Us). Https://Clinicaltrials.Gov/Study/Nct05303519
[5].
Colovos, C., & Yeates, T. O. (1993). Verification Of Protein Structures: Patterns Of Nonbonded Atomic Interactions. Protein Science, 2(9), 1511–1519. Https://Doi.Org/10.1002/Pro.5560020914
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| Paper Type | : | Research Paper |
| Title | : | Adsorption Of Recalcitrant Basic Blue 3 Dye Using Coffee Husks Powder: Equilibrium And Kinetics Studies |
| Country | : | Kenya |
| Authors | : | Wycliffe C. Wanyonyi || Gilbert K. Cheruiyot || Kiplimo J. Joyce |
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: | 10.9790/ 264X-1105013744 |
Abstract: Coffee Husks Powder (CHP) was evaluated for potential application in adsorptive removal of recalcitrant Basic Blue 3 (BB3) dye from aqueous solution. Basic Blue 3 dye is among extensively used colorant in textile industries to impart color while posing serious ecological challenges and health related risks. Batch adsorption experiments were designed ascertain the influence of pH, dye concentration, adsorbent dose, and contact time in dye removal by CHP. Dye.......
Keywords: Basic Blue 3 Dye, Coffee Husks Powder, adsorption, kinetics, equilibrium
[1] U. Roy Et Al., “Dye Removal Using Microbial Biosorbents,” In Green Adsorbents For Pollutant Removal, Vol. 19, G. Crini And E. Lichtfouse, Eds., In Environmental Chemistry For A Sustainable World, Vol. 19. , Cham: Springer International Publishing, 2018, Pp. 253–280. Doi: 10.1007/978-3-319-92162-4_8.
[2] S. Hussain, N. Khan, S. Gul, S. Khan, And H. Khan, “Contamination Of Water Resources By Food Dyes And Its Removal Technologies,” In Water Chemistry, M. Eyvaz And E. Yüksel, Eds., Intechopen, 2020. Doi: 10.5772/Intechopen.90331.
[3] J. N. Wekoye, W. C. Wanyonyi, And P. T. Wangila, “Adsorption Of Recalcitrant Malachite Green Dye From Aqueous Solution Using Cabbage Waste Powder,” Presented At The Technologies And Materials For Renewable Energy, Environment, And Sustainability: Tmrees23fr, Metz, France: Aip Publishing, 2023, P. 020002. Doi: 10.1063/5.0172478.
[4] W. C. Wanyonyi, J. M. Onyari, P. M. Shiundu, And F. J. Mulaa, “Biodegradation And Detoxification Of Malachite Green Dye Using Novel Enzymes From Bacillus Cereus Strain Km201428: Kinetic And Metabolite Analysis,” Energy Procedia, Vol. 119, Pp. 38–51, July 2017, Doi: 10.1016/J.Egypro.2017.07.044.
[5] S. Asad, M. A. Amoozegar, A. A. Pourbabaee, M. N. Sarbolouki, And S. M. M. Dastgheib, “Decolorization Of Textile Azo Dyes By Newly Isolated Halophilic And Halotolerant Bacteria,” Bioresour. Technol., Vol. 98, No. 11, Pp. 2082–2088, Aug. 2007, Doi: 10.1016/J.Biortech.2006.08.020.