Series-1 (Mar. – Apr. 2020)Mar. – Apr. 2020 Issue Statistics
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| Paper Type | : | Research Paper |
| Title | : | Logistic Regression Analysis of Diabetes Mellitus Patients Using Clinical Diagnosis in Debre Berhan Referral Hospital, Debre Berhan, Ethiopia |
| Country | : | Ethiopia |
| Authors | : | A.R.Muralidharan || WudnehKetema Moges |
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: | 10.9790/264X-0602010110  |
Abstract: Diabetes mellitus (DM) is a metabolic disorder where by glucose cannot effectively get transported out of the blood. It is a chronic disease with a high prevalence and a growing concern in worldwide. There are two Types of diabetes, which are Type I and Type II. A longitudinal data analysis retrospective based study was conducted between 1 st September, 2012 to 30 th August 2015 in Debre Berhan referral hospital.The main objective of the study was to analysis of progression of Diabetes Mellitus patients using fasting blood sugar level count following insulin, metformin and to identify factors predicting the progression of diabetic infection using logistic regression. Methods: A total of 248.....
Key Words: Diabetics, Diabetes Mellitus, Clinical diagnosis of insulin, Referral Hospital, Logistic regression
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[3]. Donald r. Hedeker and robert d. Gibbons., (2006). Longitudinal data analysis. J. Wiley and sons.
[4]. D. R. Whiting, l. Guariguata, c. Weil, and j. Shaw., (2011 and 2030). IDF diabetes atlas, global estimates of the prevalence of diabetes, diabetes research and clinical practice, vol. 94, no. 3, pp. 311–321.
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| Paper Type | : | Research Paper |
| Title | : | Recent Advancement in Using Genetic Engineering for Curing Deadly Diseases |
| Country | : | India |
| Authors | : | Kamal Murtala Farouq || Abdulaziz Umar Kurya |
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: | 10.9790/264X-0602011117 |
Abstract: CAR T-cell remedy is a "precision medicine" treatment, which means remedy that is tailored to person sufferers. It also belongs to a brand new group of most cancers treatments known as immunotherapy. In CAR T Cell remedy, a person's T-cells which might be a number of the body's maximum essential immune cells are taken from their blood, and then infused into the man or woman's bloodstream. As of late, one of the most encouraging novel malignancy treatments has been the improvement of illusory antigen receptor CAR T cells. Their best model is focusing on the B cell lineage explicit surface antigen CD19, But CARs allow T-cells to locate and kill most cancers-carrying cells, that may otherwise be tough to perceive. Once within the bloodstream, CAR T-cells maintain to multiply, and this is why the treatment is every now and then called a "living drug."In one tisagenlecleucel.....
Key Words: T cell · Gene modification, chimeric antigen receptor, Cancer, immunotherapy
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[2]. Fox, Maggie (July 12, 2017). "New Gene Therapy for Cancer Offers Hope to Those With No Options Left". NBC News.
[3]. Srivastava S, Riddell SR (August 2015). "Engineering CAR-T cells: Design concepts". Trends in Immunology.
[4]. Sadelain M, Brentjens R, Rivière I (April 2013). "The basic principles of chimeric antigen receptor design". Cancer Discovery.
[5]. Hartmann J, Schüßler-Lenz M, Bondanza A, Buchholz CJ (2017). "Clinical development of CAR T cells-challenges and opportunities in translating innovative treatment concepts". EMBO Molecular Medicine.
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| Paper Type | : | Research Paper |
| Title | : | The Glutamic Acid Decarboxylase (GAD1) Gene Polymorphisms (Rs 3749034 and Rs 11542313) and Their Association to Attention- Deficit\ Hyperactivity Disorder (ADHD) |
| Country | : | Egypt |
| Authors | : | HebaKamelAnwer Rady || Mohammad Abd El Hakeem Seleem || ManalAbd El-Wahed Eid || Sahar Ahmed Fathi Hammoudah |
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: | 10.9790/264X-0602011826 |
Abstract: Objectives: Attention-deficit hyperactivity disorder (ADHD) is a common childhood-onset neurodevelopmentaldisorder and may persist into adulthood. ADHD is a complex and heterogeneous disorder with a strong heritability estimation averaging 75% in children. Recent studies recommended a role for the γ-aminobutyric acid (GABA) on ADHD etiology due to behavioral disinhibitioncaused by inappropriate modulation of glutamatergic and GABAergic signaling.The glutamic acid decarboxylase (GAD1) gene encodes a key enzyme of GABA biosynthesis. Aim of the Study: The study aims to explore the potential association between attention deficit \hyperactivity disorder (ADHD) and glutamic acid decarboxylase.....
Key Words: ADHD; GABA; GAD1; susceptibility; association
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[2]. Wankerl B, Hauser J, Makulska-Gertruda E, et al. (2014): Neurobiology of attention deficit hyperactivity disorder. FortschrNeurolPsychiatr.; 82:9–29.
[3]. Silveri MM, Sneider JT, Crowley DJ, et al. (2013): Frontal lobe g-aminobutyric acid levels during adolescence: Associations with impulsivity and response inhibition. Biol Psychiatry; 74:296–304.
[4]. Gilbert DL, Isaacs KM, Augusta M, et al. (2011): Motor cortex inhibition: A marker of ADHD behavior and motor development in children. Neurology; 76:615–621.
[5]. Bruxel EM, Akutagava-Martins GC, Salatino-Oliveira A, et al. (2016): GAD1 Gene Polymorphisms Are Associated With Hyperactivity in Attention-Deficit/ Hyperactivity Disorder. Am J Med Genet Part; 171B:1099–1104.