Abstract: Background: Scrub typhus (ST), caused by Orientia tsutsugamushi, is an emerging and often under diagnosed cause of acute febrile illness (AFI) in India. Early diagnosis is essential for timely treatment and disease control.
Objectives: This study aimed to determine the sero-molecular epidemiology of O. tsutsugamushi among AFI cases in Surat, South Gujarat, and assess the diagnostic performance of Weil-Felix test (WFT), IgM ELISA, and nested PCR (nPCR).
Methods: A total of ≈600 blood samples from clinically suspected AFI cases were screened using the pooled WFT. Of...
Keywords: Scrub typhus (ST); Orientia tsutsugamushi; Acute Febrile Illness (AFIs); IgM ELISA; Nested PCR (nPCR); Weil-Felix test (WFT); Gujarat; Karp strain
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