iosr-JDMS   Volume-23 ~ Issue-10 ~ October 2024

Abstract: Background: Stevens-Johnson Syndrome SJS is a rare but very serious mucocutaneous disease primarily caused by medications that includes antibiotics. This case report is about a 35-year-old male who suffered from SJS due to treatment for urinary tract infection using co-trimoxazole. Case Presentation: The patient began with symptoms of flu, later on followed by rapid progression of erythematous rash and painful mucosal involvement. On clinical examination, there were blisters, skin detachment involving 10%.......

Keywords: Stevens-Johnson Syndrome, co-trimoxazole, drug hypersensitivity, antibiotic-induced reactions

[1]. Lee, E. Y., Knox, C., & Phillips, E. J. (2023). Worldwide Prevalence Of Antibiotic-Associated Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis: A Systematic Review And Meta-Analysis. Jama Dermatology, 159(4), 384–392.
[2]. Mockenhaupt, M., Dunant, A., Paulmann, M., Et Al. (2016). Drug Causality In Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis In Europe: Analysis Of 10 Years Regiscar-Study. Pharmacoepidemiology And Drug Safety, 25(Suppl 3), 3.
[3]. Hsu, D. Y., Brieva, J., Silverberg, N. B., & Silverberg, J. I. (2016). Morbidity And Mortality Of Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis In United States Adults. Journal Of Investigative Dermatology, 136(7), 1387–1397.
[4]. Lipovy, B., Holoubek, J., Hanslianova, M., Cvanova, M., Klein, L., Grossova, I., Zajicek, R., Bukovcan, P., Koller, J., Baran, M., Et Al. (2021). Impact Of Antibiotics Associated With The Development Of Toxic Epidermal Necrolysis On Early And Late-Onset Infectious Complications. Microorganisms, 9(1), 202.
[5]. Acharya, A., Acharya, S. P., & Bhattarai, T. R. (2020). Cotrimoxazole Induced Steven Johnson Syndrome: A Case Report. Jnma Journal Of Nepal Medical Association, 58(229), 702–704.

Abstract: Background The aim of the study is to compare the results of non-descent vaginal and total abdominal hysterectomy procedures done in women in a tertiary care hospital. A retrospective study done by collecting the data from medical records who underwent non-descent vaginal and total abdominal hysterectomy done in women with fibroids, adenomyosis, endometrial atypical hyperplasia and abnormal uterine bleeding. Materials and Methodology This was a retrospective......

Keyword: Total abdominal hysterectomy, non-descent vaginal hysterectomy, gynaecological diseases, operative outcome

[1] Juha Makinen, Jari Johansson, Candido Tomas, Eija Tomas, Pentti K Heinonen Et Al Morbidity Of 10110 Hysterectomies By Type Of Approach. Human Reproduction 2001; 16(7):1473-1478
[2] Wicox Ls, Koonin Lm, Peterson Hb, Pokras R Et Al Hysterectomy In The United States 1988-1990. Obstet Gyn 1994; 83:549-555
[3] V De Leo, P De Palma, A Ditto Et Al Total Abdominal Hysterectomy: A Randomized Study Comparing Two Techniques 1999 Aug: 85(2):141-5
[4] Tejal L.Patel*, Rinkal R.Patel, Vaibhavi Vaghela, Comparative Study Of Non-Descent Vaginal Hysterectomy With Abdominal Hysterectomy, International Journal Of Reproduction, Contraception, Obstetrics And Gynecologypatel Tl Et Al. Int J Reprod Contracept Obstet Gynecol. 2019 Jan;8(1):308-312
[5] Katja Stenstrom Bohlin Et Al Am J Obstet Gynecol 2017 Jan: 216(1):53. E1-53.E9.

Abstract: Background: Opioid-free anesthesia (OFA) is gaining prominence, particularly in neurosurgery, due to its potential to minimize opioid-related complications such as postoperative nausea and vomiting (PONV) and shivering. This Prospective observational study aims to compare the efficacy of a standard drug dose mixture comprising intravenous magnesium sulphate, lignocaine, paracetamol, and tramadol with fentanyl in attenuating the hemodynamic stress response during laryngoscopy and tracheal intubation. Methods: Sixty:......

Keyword: Opioid-free anesthesia, Hemodynamic stress response, Laryngoscopy, Tracheal intubation, Neurosurgery, Standard drug dose mixture, Fentanyl, Multimodal analgesia

[1] Imran Ahmed Khan, Shiv Kumar Singh. Efficacy, Safety, And Patient Satisfaction Of A Simple Combination Of Readily Available Medications (Shiv-Mix) For Perioperative Analgesia, Hemodynamic Stability, And Postoperative Recovery Profile. *Journal Of Anaesthesia And Critical Care Case Reports*. 2020; 6(1):13-18.
[2] Kothari D, Bansal A, Sunny SA. Effect Of Pre-Emptive Intravenous Paracetamol, Magnesium Sulfate, And Lignocaine On Hemodynamic Variables During Perioperative Period In Preeclampsia Patients Scheduled For Lower Segment Cesarean Section Under General Anesthesia: A Prospective Randomized Study. *Asian J Med Sci*. 2022; 13(12):29-36.

Abstract: An eruption cyst (EC) is a benign, nonodontogenic lesion. It appears as a Semi-spherical swelling in the mucosa overlying an erupting tooth. This condition occurs when the dental follicle separates from the crown, leading to the formation of a fluid-filled space. Eruption cysts usually have an epithelial lining and are encased in fibrous connective tissue. In a case involving an eleven-year-old girl, a painless, dome-shaped swelling was observed in the lower left posterior region of her jaw. This was diagnosed as an eruption cyst associated with tooth 35. An inferior alveolar nerve block was.....

Keywords: Benign cyst, Eruption cyst, Horizontal incision

[1] Shafer WG, Hine MK, Levy BM. Shafer's Textbook Of Oral Pathology. 6th Ed. Philadelphia: Elsevier; 2009. 71-110.
[2] Gaddehosur CD, Gopal S, Seelinere PT, Nimbeni BS. Bilateral Eruption Cysts Associated With Primary Molars In Both The Jaws. Case Reports. 2014 May 1;2014:Bcr2013202606.
[3] American Academy Of Pediatric Dentistry. Management Considerations For Pediatric Oral Surgery And Oral Pathology. The Reference Manual Of Pediatric Dentistry. Chicago, Ill.: American Academy Of Pediatric Dentistry; 2023:527-36.
[4] Bansal MB, Kumari A, Asrani KH, Yadav A. Eruption Cyst Treated With Diode Laser: A Case Report. International Journal Of Clinical Pediatric Dentistry. 2022 Mar;15(2):215.
[5] Kumari A, Thomas AM, Kundra R, Kumar R. Eruption Cyst: A Literature Review And Case Report. International Journal Of Applied Dental Sciences. 2021;7(1):363-6.

Abstract: This review article focuses on the essential topic of antibiotic resistance, a growing global health threat that calls into question the efficacy of previously effective therapies. It starts by recognizing the enormous influence that antibiotics, which were discovered in the 20th century, have had on medicine. Despite their effectiveness in treating infections, these medications' overuse and abuse have had unforeseen repercussions. Pathogens have evolved a number of defense mechanisms against antibiotics as their usage in human healthcare, agriculture, and animal husbandry has increased. This resistance extends throughout communities and the environment in addition to occurring in.....

Keywords: Antibiotic resistance, Transmission of illness, β-lactamase enzymes, resistant strains, multipronged strategy.

[1] Davies J, Davies D. Origins And Evolution Of Antibiotic Resistance. Microbiol Mol Biol Rev. 2010 Sep;74(3):417-33.
[2] Alekshun Mn, Levy Sb. Molecular Mechanisms Of Antibacterial Multidrug Resistance. Cell. 2007 Mar 23;128(6):1037-50.
[3] Maxwell A, Dowson Cg, Spencer J. The Molecular Basis Of Antibiotic Action And Resistance. J Mol Biol. 2019 Aug 23;431(18):3367-3369.
[4] Gniadkowski M. Evolution Of Extended-Spectrum Beta-Lactamases By Mutation. Clin Microbiol Infect. 2008 Jan;14 Suppl 1:11-32.
[5] Morar M, Wright Gd. The Genomic Enzymology Of Antibiotic Resistance. Annu Rev Genet. 2010;44:25-51..

Abstract: Résumé Introduction L'objectif était de préciser les particularités épidémiologiques et cliniques des prolapsus pelviens en Abidjan. Matériels et méthodes Une étude prospective analytique a été menée au service de gynécologie-obstétrique du Centre Hospitalier Universitaire de Treichville à Abidjan sur une période de 15 mois allant d'octobre 2022 à mars 2024. Elle incluait une série continue de toutes les patientes prise en charge pour un prolapsus des organes pelviens pendant la période. Le test de Chi deux a été utilisé pour la comparaison avec un seuil alpha fixé à 0.05 %. Résultats.......

[1] Bah M B, Diallo T O, Diallo TMO, Bah M D, Bamba S M, Diallo AB. Prolapsus Génitaux : Manifestations Urologiques Et Prise En Charge Au Service D'urologie Du CHU d'Ignace Deen. Annales De La SOGGO 2023;18(40): 45-50
[2] Bader G, Koskas M. Prolapsus Des Organes Pelviens. Du Symptôme A La Prise En Charge Thérapeutique. EMC Elsevier Masson SAS, Paris, Traité De Médecine Akos, 3-Pp1280, 2008
[3] Nayama M, Garba M, Salifou I, Idi N, Vanegas R, Djibril B. Prolapsus Génital : Prise En Charge Dans Une Maternité De Référence Du Niger Etude Prospective A Propos De 77 Cas. Med Afr Noire 2009 ; 59(2) : 107-13.
[4] Dia A, Toure C, Diop M, Thognon P, Diop A. Les Prolapsus Génitaux A Dakar. Dakar Med 1991 ; 36 : 39-45.
[5] Osei K. Wusu-Ansah, Henry S. Opare-Addo. Prolapsus Des Organes Pelviens Dans Les Zones Rurales Du Ghana. Int J Gynaecol Obstet 2008 ; 103(2):121-4. Disponible En Ligne Sur Doi: 10.1016/J.Ijgo.2008.06.014.

Abstract: Positioning of iris in a custom-made ocular prosthesis is a technique sensitive proceedure, where visual assessment alone may not be accurate. The present article is an illustration of a case report highlighting a guided orientation and positioning of an iris, exacting the contralateral side of the eye, using a facebow. This technique gives an accurate registration of the position and alignment of iris disc assembly, thus giving a life-like appearance to the prosthesis.....

Keywords: pthisical eye, custom ocular prosthesis, iris orientation

[1] Doshi Pj, Aruna B. Prosthetic Management Of Patient With Ocular Defect. J Ind Prosthodont Soc 2005; 5: 37-38.
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Abstract: Résumé : L'étude des anticorps anti-HLA est d'une importance ultime dans le bilan pré-greffe rénale. La technologie Luminex a dépassé de loin les anciennes techniques pour la recherche et l'identification des anticorps anti-HLA cependant, elle n'est pas dénuée de limites vu qu'elle est soumise à de nombreux artefacts qui rendent difficile l'interprétation des résultats.........

[1] Ann Biol Clin 2014 ; 72 (2) : 178-84 Pièges De L'interprétation Des Anticorps Anti-Hla Par Technologie Luminextmpitfalls In Interpreting Anti-Hla Antibodies By Luminextmtechnology(Mail)
[2] Aubert O, Loupy A, Hidalgo L, Duong Van Huyen J-P, Higgins S, Viglietti D, Et Al. Antibodymediated Rejection Due To Preexisting Versus De Novo Donor-Specific Antibodies In Kidney Allograft Recipients. J Am Soc Nephrol Jasn. 2017 Jun;28(6):1912–23.
[3] Cytotoxicite´ Des Anticorps Anti-Hla Naturels Chez Des Patients Marocains Candidats A` La Greffe Re´Nalecytotoxicity Of Natural Anti-Hla Antibodies In Moroccan Patients Awaiting For Kidney Transplantation Nadia Benseffaj A, *, B, Sanae Ouadghiri A, Asmaa Drissi Bourhanbour A, Asmae Noor Zerrouki B, Malika Essakallia,B
[4] Enhancing Precision Of The Single-Antigen Bead (Sab) Assay: Considerations And Challenges Vikash Chandra Mishra* And Vimarsh Raina Author Information Journal Of Clinical And Translationalpathology2024;4(1):12-17 [4] Développement D'un Outil D'aide À L'interprétation Des Résultats De Tests De Single Antigen Hla Dans Le Cadre De La Greffe D'organes Bastien Cauquil P28

Abstract: Objective: The objective of the study was to determine the frequency and intensity of vitamin D insufficiency in individuals with type 2 diabetes mellitus (DM). Methods: This retrospective investigation was carried out in the Department of Medicine over a one-year period. After receiving the consent of the patients and approval from the Ethical committee, a total of 200 participants were recruited for the study. Out of them, 100 healthy individuals were included as the case group (Group-A) and.....

Keywords: Prevalence, Severity, Vitamin D deficiency, Diabetes Mellitus

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[4] Holick Mf. Vitamin D Deficiency. N. Eng. J. Med. 357(3), 266–281 (2007).
[5] Calvo Ms, Whiting Sj, Barton Cn. Vitamin D Intake: A Global Perspective Of Current Status. J. Nutr. 135(2), 310–316 (2005).
[6] Wortsman J, Matsuoka Ly, Chen Tc, Lu Z, Holick Mf. Decreased Bioavailability Of Vitamin D In Obesity. Am. J. Clin. Nutr. 72(3), 690–693 (2000).

Abstract: Objective: To assess the clinico-demographic profile thyroid dysfunction (TD in patients with metabolic syndrome (MetS). Methods: Research was done at the Medical Department. We included 200 MetS patients in this investigation. Demographics, anthropometric measurements, significant medical (including FPG, serum TG, and HDL-C values from patients' medical records) and surgical history, family history, lifestyle parameters, history of obesogenic medicine.....

Keywords: Metabolic Syndrome, Hypothyroidism, Subclinical hypothyroidism, thyroid dysfunction

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[4] Fernández-Real Jm, López-Bermejo A, Castro A, Casamitjana R, Ricart W. Thyroid Function Is Intrinsically Linked To Insulin Sensitivity And Endothelium-Dependent Vasodilation In Healthy Euthyroid Subjects. The Journal Of Clinical Endocrinology & Metabolism. 2006 Sep 1;91(9):3337-43.
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Abstract: Background: The exteriorization of the uterus during a caesarean section involves carefully bringing the uterus out of the abdominal cavity and placing it on the woman's abdomen, affording surgeons better visualization and access during the procedure. Advocates of this technique argue for its routine adoption, emphasizing potential benefits such as enhanced surgical precision and reduced risk of complications. Conversely, critics raise concerns regarding associated risks, including increased likelihood of infection and prolonged surgical time. In the complex landscape......

Keywords: Exteriorization, Caesarean Section, Surgical Procedure, Benefits and Risks

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[2] Acog Practice Bulletin No. 205: Vaginal Birth After Caesarean Delivery. Obstet Gynecol. 2019 Feb;133(2):E110-E127.
[3] Clapp Ma, Barth Wh. The Future Of Caesarean Delivery Rates In The United States. Clin Obstet Gynecol. 2017 Dec;60(4):829-839.
[4] Palmer Sk, Zamudio S, Coffin C, Parker S, Stamm E, Moore Lg. Quantitative Estimation Of Human Uterine Artery Blood Flow And Pelvic Blood Flow Redistribution In Pregnancy. Obstet Gynecol. 1992 Dec;80(6):1000-6.
[5] Barber El, Lundsberg Ls, Belanger K, Pettker Cm, Funai Ef, Illuzzi Jl. Indications Contributing To The Increasing Caesarean Delivery Rate. Obstet Gynecol. 2011 Jul;118(1):29-38.

Abstract: Résumé Les sarcomes de type Ewing (Ewing-like) sont un sous-groupe émergent de petits sarcomes ronds à globules bleus qui partagent divers degrés de similitude morphologique, immunohistochimique, moléculaire et clinique avec le sarcome d'Ewing. Nous rapportons le cas d'un patient âgé de 25 ans, tabagique chronique sevré qui présentait depuis 2 mois une douleur thoracique. L'examen clinique une pâleur cutanéo-muqueuse. La TDM thoracique a montré un processus tissulaire en regard du segment postérieur du lobe supérieur gauche ovalaire de contour régulier. L'IRM médullaire a objectivé un volumineux processus centré sur les arcs postérieur du 4 ème au 6 ème.......

[1] Renzi S. Et Al. Ewing-Like Sarcoma: An Emerging Family Of Round Cell Sarcomas. Journal Of Cellular Physiology (2018)
[2] Le Sarcome D'ewing Et Les Nouveaux Sarcomes Emergents De Type Ewing : (Sarcomes Réarrangés Cic Et Bcor). Une Revue Systématique 2016 Novembre ; 31(11):1169-81
[3] Cash T, Comparison Of Clinical Features And Outcomes In Patients With Extraskeletal Versus Skeletal Localized Ewing Sarcoma.2016;63(10)
[4] Sbaraglia, M., Righi, A., Gambarotti, M., Et Dei Tos, A. P. (2019). Sarcome D'ewing Et Tumeurs De Type Ewing. Virchows Archiv. Doi :10.1007/S00428-019-02720-8
[5] Yoshida A, Goto K, Kodaira M, Kobayashi E, Kawamoto H, Mori T, Et Al. Cic-Rearranged Sarcomas: A Study Of 20 Cases And Comparisons With Ewing Sarcomas. Am J Surg Pathol. 2016; 40: 313–23

Abstract: Background: prehypertension is asymptomatic and yet a warning sign that the patient may develop hypertension and its complications in his near future. Micro-albuminuria in these cases is a predictor of higher risk of cardiovascular and renal dysfunction and hence early detection will help us to control the development of htn and its complications. Aim: to evaluate.....

Keywords: prehypertansive, microalbuminuria,complications

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Abstract: Background: chronic liver failure is usually associated with hypersplenism and diminished erythrocyte survival is frequent. Dietary deficiencies, alcoholism, bleeding and defective hepatic synthesis of proteins used in blood formation or coagulation worsen the problem. Plasma volume is increased in patients with cirrhosis,particularly in those with ascites ,this hypervolemia may account for a low peripheral hemoglobin or erythrocyte level. Materials and methods: this is a crosssectional,analytical study of 100 patients conducted in patients with decompensated chronic liver disease admitted in siddhartha medical college hospital during the period january 2023 to december 2023.......

[1] Kuntz E, Kuntz H. Hepatology, Textbook And Atlas. Heidelberg: Springer
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[4] Lahari J, Usmani Mh, Kapur Ks, Shukla Ak. Clinical And Haematological Abnormalities In Decompensated Chronic Liver Disease Patients. J Assoc Physicians India. 2022 Apr
[5] Sengupta S, Vidyapati, Mazumdar P. Prevalence Of Various Hematological Abnormalities In Patients With Decompensated Chronic Liver Disease. J Assoc Physicians India. 2020

Abstract: Background: Vitamin D deficiency during pregnancy has been implicated in various adverse maternal and neonatal outcomes. This study aims to assess the prevalence of Vitamin D deficiency among pregnant women in Bangladesh and its association with neonatal and delivery outcomes. Methods: This cross-sectional observational study was conducted at Chattogram Medical College Hospital and other private hospitals in Chattogram from January 2022 to June 2023. A total of 91 pregnant women who provided informed consent were......

Keywords: Vitamin D Deficiency, Pregnancy, Neonatal Outcomes, Postpartum Hemorrhage, Bangladesh

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Abstract: Background: The COVID-19 pandemic presents unique challenges in managing pregnant women, especially in predicting disease severity and adverse clinical outcomes. D-dimer, a fibrin degradation product, is a well-known biomarker for thrombosis and disseminated intravascular coagulation (DIC). Its significance in assessing the severity of COVID-19 infection in pregnant women is critical. This study aimed to evaluate the role of D-dimer as a biomarker for disease severity and morbidity in third-trimester COVID-19 positive pregnant women......

Keywords: COVID-19, D-dimer, pregnant women, disease severity, biomarker, morbidity

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[4]. Lippi G, Bonfanti L, Saccenti C, Cervellin G. Causes of elevated D-dimer in patients admitted to a large urban emergency department. European journal of internal medicine. 2014 Jan 1;25(1):45-8.
[5]. Zhang L, Yan X, Fan Q, Liu H, Liu X, Liu Z, Zhang Z. D‐dimer levels on admission to predict in‐hospital mortality in patients with Covid‐19. Journal of thrombosis and haemostasis. 2020 Jun 1;18(6):1324-9.