Abstract: Objective: This study was undertaken to evaluate the anti-obesity potential of the methanolic extract of leaves of Heritiera fomes. (MEHF) in high fat cafeteria diet (HFCD) fed obese rats.
Methods: Wistar strain of albino rats were divided into six groups comprising of six rats each. Group I served as normal control fed with normal pellet chow, group II served as disease control fed with high fat cafeteria diet, group III, IV and V animals, received MEHF at a dose level of 100, 200 and 400mg/kg b.w along with HFCD for 40 days, while, group VI served as standard drug control, which received Orlistat at a dosage of 50mg/kg b.w along with HFCD.............
Keywords: High Fat Cafeteria diet, Obesity, Heritiera fomes, Orlistat.
[1]. Vinay Kumar, Uma Bhandari, Chakra Dar Tripathi, Geetika Khanna. Evaluation of antiobesity and cardioprotective effect of Gymnema sylvestre extract in murine model. Indian J Pharmacol 2012; 44(5): 607-613.
[2]. Mokdad A, Ford E, Bowman B, Dietz W, Vinicor F, Bales V, Marks J. Prevalence of obesity, diabetes, and obesity related health risk factors. JAMA 2003; 289: 76–79.
[3]. Cragg GM, Newman DJ. Natural Product Drug Discovery in the Next Millennium. Pharm Biol 2001; 39(1): 8-17.
[4]. Ali, K. Nahar, M. Sintaha et al., "An evaluation of antihyperglycemic and antinociceptive effectsof methanol extract of Heritiera fomes Buch- Ham. (Sterculiaceae) barks in Swiss albino mice," Advances in Natural and Applied Sciences, vol. 5, no. 2, pp. 116–121, 2011.
[5]. M. A. Hossain, S. Panthi, M. Asadujjaman, S. R. Khan, F. Ferdous, and S. K. Sadhu, "Phytochemical and pharmacological assessment of the ethanol leaves extract of Heritiera fomes Buch. Ham. (Family- Sterculiaceae)," Journal of Porphyrins and Phthalocyanines, vol. 2, pp. 95–101, 2013.