Abstract: Parkinson's disease (PD) is primarily recognized for its hallmark motor impairments. However, a variety of non-motor symptoms often appear earlier in the disease course and significantly impact patients' quality of life. Despite extensive research, no current treatments effectively alter the progression of the disease. The most widely used therapeutic approach—levodopa—works by restoring dopamine levels to ease motor dysfunctions, but it has limited effects on non-motor...
Keywords: Parkinson's disease (PD), Neurodegenerative disorder, Alpha-synuclein, Lewy bodies, Substantia nigra, Motor symptoms, Non-motor symptoms, Bradykinesia, Tremors, Rigidity, Gait disturbances, Gastrointestinal dysfunction ETC
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