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| Paper Type | : | Research Paper |
| Title | : | Medicinal Plants Used By Traditional Healers in UNA District of Himachal Pradesh (North Western Himalayan Region), India |
| Country | : | India |
| Authors | : | Bindu Sharma |
Abstract: The present study was conducted in a Swan river (Main River of district) catchment area of district Una (H.P) to accumulate knowledge regarding diversity of plant resources that are used by local people for medicinal uses and to preserve the traditional way of curing aliments which are losing its importance in young generation. The plant kingdom represents a rich house of organic compound, many of which have been used for medicinal purposes and could serve as good efficacy in various pathological disorders in the coming years. This knowledge could be utilized in formulation of drugs..............
Keywords: Catchment area, Diversity, Organic compound, Survey Questionnaire, Participatory observations
[1] Ahluwalia, K.S Medicinal plants of Kangra valley. Indian Forester 1952, 78(4): 181-194.
[2] .Anonymous, India's Fourth National Report to Convention on Biological Diversity,(Ministry of Environmental and Forest, Govt .of India),2009.
[3] Arora, R. K.?(1987),Ethnobotany and its role in domestication and conservation of native plant genetic resources.IN :JAIN S.K,(ed.) :A Manual of Ethno botany Scientific Publishers, Jodhpur : 94-102
[4] Chauhan,N.SMedicinal and Aromatic plants of Himachal Pradesh,(Indus Publishing Company, New Delhi , 1999.
[5] Dobriyal, RM, Singh, GS, Rao, KS & Saxena, KG, Medicinal plant resources in Chhakinal watershed in north-western Himalaya. J. Herbs Spices & Medicinal Plants 1997, 5: 15-27.
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| Paper Type | : | Research Paper |
| Title | : | Antioxidant Properties and Alpha-Amylase Inhibition of Wild Blackberry Leaf |
| Country | : | Turkey |
| Authors | : | Sebnem Selen Isbilir || Hulya Yagar |
Abstract:In this study, the possible antioxidant properties of ethanolic extract of wild blackberry leaves were investigated by using antioxidant assays including DPPH• scavenging and β-carotene bleaching method. The leaf extract was showed DPPH radical scavenging activity at the 100 μg/mL and above concentrations and
inhibited lipid peroxidation at the high concentrations. The natural compounds known as potential antioxidants
such as phenolics, flavonoids were also determined. Total phenolic content was determined using Folin- Ciocalteu method and was found to be 186.05±1.46 μg of gallic acid equivalents. Total flavonoid content was
studied using AlCl3 reagent and was determined as 19.39±0.83 μg of quercetin equivalents. The different
concentrations of leaf extract had α-amylase inhibitory activity in the range of 21 - 44 %. The observed inhibition effect against α-amylase could be due to phenolic contents of the plant
Keywords: α-Amylase inhibition, Wild blackberry, DPPH· scavenging, Phenolic. *This study was presented at International Congress on Applied Biological Sciences, Skopje, Republic of Macedonia, September16-20, 2015
[1]. B.Halliwell and JMC. Gutteridge, Role of free radicals and catalytic metal ions in human disease: An overview, Methods in
Enzymology, 186, 1990, 1-85.
[2]. M. Percival, Antioxidants, Clinical Nutrition Iniıghts, 10, 1998, 1-4.
[3]. A, Asgar, Anti-diabetic potential of phenolic compounds: A Review International Journal of Food Properties, 16, 2013, 91-103.
[4]. J. Xiao, X. Ni, G. Kai and X. Chen, A review on structure-activity relationship of dietary polyphenols inhibiting α-amylase.
Critical Reviews in Food Science and Nutrition, 53, 2013, 497-506.
[5]. J. Lee, M. Dossett and CE. Finn, Rubus fruit phenolic research: the good, the bad, and the confusing. Food Chemistry, 130, 2012,
785-796..
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| Paper Type | : | Research Paper |
| Title | : | Synthesis, Antimicrobial Activity and Docking Studies of Novel Urea and Thiourea Derivatives |
| Country | : | India |
| Authors | : | Glory M || Dr Kiranmai M || Dr Karunakar GV || Dr Narendra Sharat Chandra |
Abstract: Urea derivatives have been gaining the research interest due to their different biological and pharmacological activities such as anti-bacterial, anti-proliferative, antiviral, anti-cancer, anti-inflammatory and insecticidal properties. In the present study we focused on synthesis of some novel urea and thiourea derivatives through new synthetic approach and in vitro evaluation of synthesized derivatives for their antibacterial and antifungal activities. The synthesis consists of single step and includes various types of amines, isocyanates and isothiocyanates. Method consists of condensation of amines with cyanates. Nine compounds were synthesized and structures were confirmed by 1H NMR, IR and Mass spectral data. All the synthesized compounds were screened for antibacterial and antifungal activity. Synthetic approach followed in the present work was found to be safe, easy............
Keywords: Antibacterial, antifungal, Condensation, Urea derivatives and Thiourea derivatives.
[1]. C. Pardo, G. Alcatraz, M. Cascante, J.Martinez, Diphenyl Urea Derivatives Inhibitors of Transketolase: A Structure-Based
Virtual Screening; plos one, 2012;
[2]. KingkanSanphanya , Suvara K. Wattanapitayakul , OrawinPrangsaengtong , Michiko Jo,Keiichi Koizumi, Naotoshi Shibahara,
AroonsriPriprem, Valery V. Fokin, OpaVajragupta;Synthesis and evaluation of 1-(substituted)-3-prop-2-ynylureas as
antiangiogenic agents,Bioorganic and medicinal chemistry letters ,2012;22 :3001-3005.
[3]. M.Grare, M.Mourer, S.Fontanay, E.DuvaIn vitro activity of para-guanidinoethylcalix [4] arene against susceptible and antibioticresistant
Gram-negative and Gram-positive bacteria J.Antimicrob. Chemother, 2007; 60, 575-581.
[4]. G. Madhavaa, K.VenkataSubbaiah, R.Sreenivasulu and C. Naga Raju, A Synthesis of novel urea and thiourea derivatives of
diphenylphosphoramidate and their antimicrobial activityScholars Research Library Der Pharmacia Lettre, 2012;4 (4):1194-1201.
[5]. A.A. Moneer, K.A.M. Abouzid, M.M. Said, Az. J. Pharm. Sci. 30 (2002) 150.
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| Paper Type | : | Research Paper |
| Title | : | Morphological and Histological Effect of Oral Intake of Rose Water in Mouse |
| Country | : | India |
| Authors | : | Nouf Hakami || Rabah, Samar |
Abstract: Rose water (Maa El-Ward) is one of the major products of rose, it is produced from the petals of Rosa damascene and contains about 0.08-0.12% of essential rose oil. Rose water is used widely between Saudi women (Saudi Arabia), in cooking and taken orally due to its calming effect. This study has been initiated to highlight the morphological and histological changes on mice and its kidney, using two types of rose water (RW1 & RW2), by oral uptake. Eighty four adult female albino mice were divided into one control group (12 mice) that was administered distilled water and two experimental groups. Each experimental group was subdivided into three subgroups 12 each and received oral............
Keywords: Rosa damascene, Rose water, kidney, microscopic changes
[1]. Anthony, S. J.; Zuchowski, W. and Setzer, W. N. (2009): Composition of the Floral Essential Oil of Brugmansia suaveolens. Rec. Nat. Prod., (3): 76-81.
[2]. Ashrafzadeh, F.; Rakhshandah, H. and Mahmoudi, E. (2007): Rosa damascena oil: an adjunctive therapy for pediatric refractory seizer. Iranian journal of child neurology. (1):13–17.
[3]. Basim, E. and Basim, H. (2003): Antibacterial activity of Rosa damascena essential oil. Fitoterapia, (74):394-396.
[4]. Baydar, H. (2006): Oil-bearing rose (Rosa damascene Mill.) Cultivation and rose oil industry in Turkey. Euro Cosmetics, (14)13-17. [5]. Baydar, H. and Baydar, N. G. (2005): The effects of harvest date, fermentation duration and Tween 20 treatment on essential oil content and composition of industrial oil rose (Rosa damascena Mill.). Ind. Crop. Prod., (21):251–255.
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| Paper Type | : | Research Paper |
| Title | : | Clinical and Clinico-pathological Impacts of Upper Gastrointestinal Bleeding in Elderly Egyptian Patients |
| Country | : | Egypt |
| Authors | : | Said Ibrahim Shalaby || Mohamed Abo-Eldahab || Hesham Abd-Elhafeez || Mona Abdel Kader Awad || Medhat Attia || Neelima Gupta |
Abstract: Gastrointestinal (GI) bleeding in elderly is a common problem with numerous causes. The study included 120 patients who attended gastrointestinal endoscopic unit, SayedGalal Hospital, Al-Azhar University, Cairo, Egypt suffering from upper gastrointestinal bleeding. Patients were divided into 2 groups (n=60): Group I: below 55 and Group II: above 55 years. Sixty percent of elderly group presented with hematemesis and melena while 40% with melena. The present study revealed that esophageal varices were responsible for 45% deaths of elderly patients with upper gastrointestinal bleeding............
Keywords: GI bleeding,Predicting factors, Endoscopy, Laboratory analysis
[1]. Abdel-Wahab M, Rabab F, Moamean K and Soheir Z (1993) Contribution of hepatitis B, C viruses in morbidity of schistosomiasis in a rural village in Menofya governorate. 9th Training Workshop ,9th Afro Arab Conference on liver and biliary diseases.
[2]. Antler A, Pitchumoni C, Thomas E and Orangio G (1981) Gastrointestinal bleeding in the elderly. Morbidity, mortality and causes. Am J Surg 142(2) : 271-273.
[3]. Belohlavek J, Hruby M, Polack F and Barolik M (2001) Non variceal acute upper digestive tract hemorrhage. Therapeutic approach. CasLekCesk24 : 149 (1): 295.
[4]. Blatchford O, Davidson I and Murray W (1997) Acute upper gastrointestinal hemorrhage in west Scotland. Case ascertainment study. Brit Med J 315 : 510.
[5]. Bullimore D, Miloszewski K and Losowsky M (1989) The prognosis of elderly subjects with esophageal varices. Age Ageing 18(1) : 35-38.
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| Paper Type | : | Research Paper |
| Title | : | Teratogenic Effects and Maternal Toxicity of Sprague Dawley Rats Fed FicusdeltoideaLeaves AqueousExtract inLate Gestation |
| Country | : | Malaysia |
| Authors | : | Abdullah F || Hussin H. || Sukardi S. |
Abstract: Ficusdeltoidea have many beneficial uses however no report has been documented on the possible teratogenic effects if consumed during pregnancy. A study was conducted to observe the effects of feeding Ficusdeltoidea leaves aqueous extract (FDLAE) to rats during the late gestation period. Thirty pregnant Sprague Dawley rats were divided equally into five groups: positive control (retinylpalmitate in corn oil), negative control (only water), vehicle control (corn oil), low dose (5g/kg/day) and high dose (10g/kg/day) of FDLAE. Dams were sacrificed at...............
[1]. Adam Z, Khamis S, Ismail A, Hamid M. (2012). Ficusdeltoidea: A potential alternative medicine for diabetes mellitus. Evidence-Based Complementary Alternative Medicine. 201 (2): 632763. pp:1-12.
[2]. Ali Khan, S. E., and Hales, B. F. (2006). Retinoid receptor antagonists alter the pattern of apoptosis in organogenesis stage mouse limbs. Toxicological Science. 90(1): 208-220.
[3]. Anjali, S., Tanuja, N. A., Singh, J.K., and Ravish, K. (2011). Effect of Corn Oil as a Vehicle on Kidney of Female Swiss Albino Mice Mus Musculus by Gavages Method. Research Journal of Biotechnology. 6(1):15-8.
[4]. Bunawan, H., Mat Amin, N., Bunawan, S.N.,Baharum, S.N. and Mohd. Noor, N. (2014). Ficusdeltoidea Jack: A Review on Its Phytochemical and Pharmacological Importance. Evidence-Based Complementary and Alternative Medicine. pp: 1-9
[5]. Cessart,Marie.(2010). Suspected Fetal Skeletal Malformations or Bone Diseases: How To Explore. Journal of Pediatric Radiology. 40:1046-1051.
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| Paper Type | : | Research Paper |
| Title | : | Phytochemical Composition and Fungicidal Potential of Moss Philonotis Revoluta against Spore Germination Process of Fungus Helminthosporium Turcicum |
| Country | : | India |
| Authors | : | G.S.Deora || D.Suhalka |
Abstract: Information about the occurrence of phytochemicals which act as antibiotic substances in bryophytes and the medicinal use of bryophytes are sporadic. Despite of a long history of medicinal use of bryophytes by various tribal and local communities across the world, their significant utilization in medicines is still a dream due to lack of concise ethnobotanical information, scarcity of material degrading habitats etc. Bryophytes have emerged as potential plants for many bioactive phytochemicals with antimicrobial efficacies. Antifungal activity of a moss Philonotis revoluta has been assessed using various extracts..............
Keywords: Phytochemical, Fungicidal potential, Moss, Philonotis revoluta, Helminthosporium turcicum, Hanging drop technique
[1]. Flowers, S, 1957. Ethnobryology of the Gosiute Indians of Utah. Bryologist. 60, 11–14.
[2]. Ellof, JN., 1998. Which extractant should be used for the screening and isolation of antimicrobial components from plants? J. Ethnopharmacol. 60, 1-6.
[3]. Frahm, JP, 2004. New frontiers in bryology and lichenology: Recent developments of commercial products from bryophytes. Bryologist. 107, 277-283.
[4]. Asakawa, Y., 2001. Recent advances in phytochemistry of bryophytesacetogenins, terpenoids and bis (bibenzyl) from selected Japanese, Taiwanese, New Zealand, Argentinean and European liverworts. Phytochemistry. 56, 297-312.
[5]. Ilhan, S. et.al., 2006. Antimicrobial activity of Palustriella commutata (Hedw.) Ochyra extract (Bryophyta). Tr. J. of Biology. 30, 149-152.
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| Paper Type | : | Research Paper |
| Title | : | Bioavailability Improvement of Diltiazem Hydrochloride Gastroretentive Sustained Release Tablets |
| Country | : | Egypt |
| Authors | : | Thanaa M. Borg || Marwa S. El-Dahan || Hayder A. Hammoodi |
Abstract: Floating drug delivery system (FDDS) is the greatest interesting endeavors facing the pharmaceutical scientist. FDDS are associated with advantages of improved bioavailability and minimizing the dosing frequency. Diltiazem hydrochloride (DTZ HCl) is a calcium channel blockers, anti-anginal drug and anti-hypertensive which undergo extensive first-pass metabolism and display poor bioavailability about 30-40%. In this research, formulation of DTZ HCl sustained release floating tablets to be taken once was attempted. These tablets were formulated using different release-retarding polymers as...............
Keywords: Bioavailability, Diltiazem hydrochloride, Floating, Gastroretentive.
[1]. N. Tavakoli, J. Varshosaz, F. Dorkoosh, S. Motaghi and L. Tamaddon, Development and evaluation of a monolithic floating drug delivery system for acyclovir, Chem. Pharm. Bull. 60 (2), 2012, 172-177.
[2]. C. Sauzet, M. Claeys-Bruno, M. Nicolas, J. Kister, P. Piccerelle, and P. Prinderre, An innovative floating gastro retentive dosage system: formulation and in-vitro evaluation, Int. J. Pharm., 378 (1-2), 2009, 23-29.
[3]. K. P. R. Chowdary, and S. A. Hussainy, Formulation and evaluation of floating tablets of gliclazide employing HPMC and carbopol, Int. J. Chem. Sci., 10(3), 2012, 1213-1220.
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| Paper Type | : | Research Paper |
| Title | : | Effect of Aqueous Extract of Defatted Flaxseeds (Linum Usitatissimum Linn) on Fructose-Induced Hypertension in Rats by Inhibiting Angiotensin-Converting Enzyme (ACE) |
| Country | : | Malaysia |
| Authors | : | Shweta Gokhale || Alakh N Sahu |
Abstract: Linum usitatissimum Linn. is a widely acclaimed medicinal plant used in every household. The seeds of L. usitatissimum have both medicinal and nutraceutical properties.The study was conducted to evaluate the anti-hypertensive effect of aqueous extract with Secoisolariciresinol Diglucoside (SDG) enriched fraction (SEF) of defatted flaxseeds on fructose-induced hypertension in rats.Hypertension was induced by administration of 10% w/v solution of fructose orally in drinking water. Hypertension developed was confirmed by Systolic blood pressure (SBP) measured after 2 weeks of administration...............
Keywords: Angiotensin converting enzyme,Flaxseed, Hypertension, Lignans, Secoisolariciresinol Diglucoside
[1]. Amarowicz, R., Karamac, M., Wanasundara, J.P.D. and Shahidi, F., 1997. Antioxidant activity of hydrophobic phenolic fractions of flaxseed. Food/Nahrung,41(3), pp.178-180.
[2]. Bloedon, L.T., Balikai, S., Chittams, J., Cunnane, S.C., Berlin, J.A., Rader, D.J. and Szapary, P.O., 2008. Flaxseed and cardiovascular risk factors: results from a double-blind, randomized, controlled clinical trial. Journal of the American College of Nutrition,27(1), pp.65-74.
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| Paper Type | : | Research Paper |
| Title | : | Phytochemical, Antimicrobial Analysis and wound Healing Activities of Ganoderma Lucidium |
| Country | : | India |
| Authors | : | Jasmin Dora || Vimalin Hena |
Abstract: Ganoderma lucidium mushrooms are an important natural source of foods and medicines. Mushrooms represent a major and untapped source of potent new pharmaceutical products. Traditional aboriginals knew the medicinal importance of edible and wild mushrooms and these are now being screened for their bioactivity in various ailments. The effect of Ganoderma lucidium extract on cancer, hypertension, hypercholesterolemia, hepatitis, wound healing and antimicrobial activities have been reported by many researchers...............
Keywords: Ganoderma lucidium, antimicrobial, phytochemical analysis, wound healing activity
[1]. Carson, C.F. Hammer, K.H. Riley, T.V. (2006), Melaleuca alternifolia (Tea Tree) oils; A review of Antimalarial and other medicinal properties, Clinical microbiology, Review, 19 (1)150-162.
[2]. Dei, H.K. Rose, S.P and Mackenzie A. (2007), Shea nut, (Vitellaria paradoxa) meal as a feed ingredient for poultry. In World Poultry Science Journal. 63(4). 611-624.
[3]. Edris, A.A. (2007), Pharmaceutical and therapeutic potentials of essential oils and their individual volatile Constituents; A Review, Phytotherapia Research 21(4)308-323.
[4]. Idowu, Y.O. Onawunmi, G.O. Ogundani, A.O. Adesanya, S.A. (2003), Antimicrobial constituents of Crysophyllum albidum seed: Cotyledon. Nigerian Journal of veterinary production and medicine. 7:33-36.
[5]. Ko. H.H. Hung, C.F. Wang, J.P., Lin, C, N. (2008) , Anti-inflammatory Triterpenoids and steroids from Ganoderma lucidium and Ganoderma Tsugae, Phytochemistry.69(1) 234-239
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| Paper Type | : | Research Paper |
| Title | : | Validated Reverse Phase Stability-Indicating Hplc Method for Clofarabine in the Presence of Degradation Products and its Process-Related Impurities |
| Country | : | India |
| Authors | : | JagadeswaraRao K || Murali Mohan SV || Rama Rao Malla |
Abstract: The study reports simultaneous determination [1] of Clofarabine and its related substances of impurities in their pharmaceutical dosage form using validated stability indicating reverse phase high performance liquid chromatography method.The column used was Inertsil ODS 3V, 250x4.6 mm, 5 μm using phosphate buffer pH 3.0: acetonitrile with gradient mixing mobile phase at a flow rate of 1.0 ml/min. Quantification was achieved with UV detection at 250 nm over the concentration range...............
Keywords: Clofarabine, Analytical Method development, Analytical Method validation and High Performance Liquid Chromatography.
[1]. Buttner B, Oertel R, Schetelig J, Middeke JM, Bornhauser, Seeling A, Knoth H, Simultaneous determination of clofarabine and cytarabine in human plasma by LC-MS/MS 2016 Jun 5;125:286-91.
[2]. De Gennero LJ, Raetz E, Acute lymphoblastic leukemia 2004.
[3]. Centre for drug evaluation and research, application number 21-673, http://www.accessdata.fda.gov.
[4]. Description of clofarabine, http://www.drugbank.ca/drugs/ DB00631
[5]. B. Zhu, J.F.Y. Huang, Zhongliu Yaoxue, 2011,1, 140.
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| Paper Type | : | Research Paper |
| Title | : | The Isolation and Structural Determination of Flavonoids from Justicia Gendarussa |
| Country | : | India |
| Authors | : | Raghu.M.G || Pushpa Agrawal |
Abstract: The current study was intended for isolation of bioactive polyphenolic compounds from methanol extract of Justicia Gendarussa and their subsequent characterization. The flavonoid compounds were isolated and identified by using thin layer chromatography (TLC), were qualified by using reverse phase high performance chromatography (RP-HPLC). Their structures and chemical bonds were analyzed using Ultraviolet-Visible spectrophotometer (UV-VIS spectrophotometer), Fourier Transform-Infra Red spectroscopy (FTIR), Nuclear magnetic resonance NMR..............
Keywords: Justicia gendarussa, TLC, HPLC, UV, FTIR, SEM, EDX, DSC, NMR, LC-MS, Apigenin, Vitexin
[1]. L.A. Shelef,Antimicrobial effects of spices,J. Food Safety, 1983, 6: 29–44.
[2]. L.L. Hargreaves, B. Jarvis, A.P. Rawlinson and J.M. Wood, The antimicrobial effects of spices, herbs and extracts from these and other food plants. Scientific and Technical Surveys, British Food Manufacturing Industries Research Association, 1975, 88: 1–56.
[3]. S.G. Deans andG. Ritchie, Antibacterial properties of plant essential oils, Int. J. Food Microbiol, 1987, 5: 165–180.
[4]. N. Nakatani,Antioxidative and antimicrobial constituents of herbs and spices, In: Charalambous.G. (ed.) Spices, Herbs, and Edible Fungi. Elsevier, Amsterdam, 1994, 251–272.
[5]. K. Hirasa andM. Takemase, Spice Science and Technology. Marcel Dekker, New York, 1993
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| Paper Type | : | Research Paper |
| Title | : | Synthesis, characterization and pharmaceutical applications of Curcumin metal complex |
| Country | : | India |
| Authors | : | Dr.A.Gubendran || Dr. M.Amutha || P.Dhanasekaran || A.Imayatharasi || M.Vijayalakshmi |
Abstract: Nowadays People are often down with dengue, pneumonia, and viral infected fever because of unclean surrounding. This is the first attempt to use curcumin complex in a model anti-bacterial assay experiment on Staphylococcus aureus, E. coli, Klebsiella pneumonia and Pseudomonas fluorescence.Results show thatcurcumincomplex has significant higher activity compared to pure curcumin. Curcumin copper complex was synthesized by using DMSO and ethanol solvent mixture at 350oC and characterised by FT- IR spectral analysis...............
Keywords: copper- curcumin complex, FT-IR,Staphylococcus aureus, E. coli, Klebsiella pneumonia and Pseudomonas fluorescence
[1]. B. Marchetti, M.P. Abbracchio, Trends Pharmacol. Sci. 26 (2005) 517.
[2]. S. Mandel, O. Weinreb, T. Amit, M.B.H. Youdim, J. Neurochem. 88 (2004) 1555.
[3]. Z.Z. Chong, F.Q. Li, K. Maiese, Prog. Neurobiol.75 (2005) 207.
[4]. O. Weinreb, S. Mandel, T. Amit, M.B.H. Youdim, J. Nutr. Biochem.15 (2004) 506.
[5]. M.T. Carri, A. Ferri, M. Cozzolino, L. Calabrese, G. Rotilio, Brain Res. Bull. 61(2003) 365.
[6]. G.L. Millhauser, Acc. Chem. Res. 37 (2004) 79.
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| Paper Type | : | Research Paper |
| Title | : | Aménorrhée Primaire Révélant un Adénome a Prolactine Evoluant Depuis L'enfance Primary Amenorrhea Revealing a Prolactinoma Evolving Since Childhood |
| Country | : | Maroc |
| Authors | : | I.Damoune || M.Rchachi || H.El Ouahabi || F.Ajdi |
Abstract: Primary amenorrhea can occur for a variety of reasons as genetic defects, tumors or hormonal disorders. We will report the cases of two adult patients with primary amenorrhea with normal secondary sexual characters revealing a prolactinoma probably evolving since childhood which stopped pubertal development before the occurrence of menstruation
Keywords: Primary amenorrhea, pituitary adenoma, hyperprolactinemia
[1]. Peigné M . Aménorrhées. Gynécologie [156-A-10]. 2014
[2]. Castinetti , Brue T. Adénome hypophysaire. Traité de medicine AKOS 3-0600. 2010
[3]. BrueT, Delemer B. French Society of Endocrinology (SFE) work group on the consensus on hyperprolactinemia. Diagnosis and management of hyperprolactinemia: expert consensus - French Society of Endocrinology. Ann Endocrinol (Paris) 2007;68:58-64.
[4]. Casanueva FF, Molitch ME, Schlechte JA, Abs R, Bonert V, Bronstein MD, et al. Guidelines of the Pituitary Society for the diagnosis and management of prolactinomas. Clin Endocrinol (Oxf) 2006;65:265-73.
[5]. Bonneville J et al. L'IRM hypophysaire : indications et résultats en gynécologie et en obstétrique. Gynécologie Obstétrique & Fertilité 2005 ; 33 : 147–153
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| Paper Type | : | Research Paper |
| Title | : | Comparative Study between Quaternary Ammonium Compounds and Formalin in Clean Room Sanitation |
| Country | : | India |
| Authors | : | M. Nadeem Javed Qureshi || Dr. Kashif A. Safdar || W. Jamil || Dr. Jawaid A. Siddiquie |
Abstract: Sanitization of Pharmaceutical clean room is always been a burning issue for clean room experts. This is not only because of the sensitivity of product manufactured in clean room but also due to emergence of natural resistance of Micro-organisms , regulatory requirement ,which are becoming strict day by day and the effect of chemicals used for the disinfection of clean on human health. Today there is a very vast range of chemicals available for clean room sanitation and each of them has its own disadvantages and advantages. Formaldehyde and Quaternary ammonium compound...............
Keywords: Formalin, Quaternary Ammonium Compound (QUATS), CFU, Sanitization, Clean room
[1]. Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008 William A. Rutala, Ph.D., M.P.H.1,2, David J. Weber, M.D.,M.P.H.1,2, and the Healthcare Infection Control Practices Advisory Committee (HICPAC)3 YOSHIHIRO OYAMA, (JP); SATORU INOUE,(JP)
[2]. Stephan M. Hubig, Maplewood, MN (US); Jaclyn Joy Steep, Woodbury, MN (Us) Vickie Leonard, RN, PhD, School of Nursing, Institute for Health & Aging, University of California, San Francisco (UCSF) Carol Westinghouse, Informed Green Solutions, Vermont Asa Bradman, PhD, Center for Environmental Research and Children's Health, School of Public Health, University of California (UC), Berkeley, Ralph Trujillo, Kermit F. Lindell Appl Microbiol. 1973 July; 26(1): 106–110. PMCID: PMC379725
[3]. Merrel C.R., M. E. Bisher, M. Harrington, A.C. Steven (1988). Coloration of Silver Stained Proteins in Polyacrylamide Gels is caused by Light Scattering from Silver Grains of Characteristic Sizes. Proc Natl Acad, 85 (2): 453-457.
[4]. Moustafa Y. M. El-Naggar,* Mohamed A. Akeila,1 Helmi A. Turk,1 Ali A. El-Ebady,2 and Mona Z. Sahaly2 (Received July 4, 2000; Accepted March 16, 2001)
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| Paper Type | : | Research Paper |
| Title | : | A Validated High Performance Liquid Chromatography Method for the Determination of Saxagliptin and Metformin in Bulk and Pharmaceutical Dosage Form, a Stability Indicating Study |
| Country | : | India |
| Authors | : | Ramesh J || Dr. Senthil Kumar N |
Abstract: A Stability indicating reverse phase high performance liquid chromatography (RP-HPLC) method was developed and validated for the simultaneous estimation of Saxagliptin (SAX) and Metformin (MET) in bulk and pharmaceutical dosage form. The separation was carried on kromasil- C18 column (4.5 x 250 mm; 5 μm) column with mobile phase consisting of 50mM sodium dihydrogen phosphate buffer (pH adjusted to 2.7 using orthophosphoric acid): methanol in the ratio of 80:20 v/v with a flow rate of 0.9 ml/min and PDA detection at 242nm. The linearity was found to be in range of 0.5-3 μg/mL (R2 = 0.9995) and 50-300 μg/mL (R2 = 0.9995) for SAX and MET respectively. The method has shown good, consistent recoveries for SAX 98.39-101.53% and MET 100.46 -101.59% respectively. The method was found to be accurate, precise, specific, robust and linear for the determination of SAX and MET in bulk and pharmaceutical dosage form
Keywords: ICH guidelines, Metformin, Method validation, RP-HPLC, Saxagliptin.
[1]. Srikanth Inturi, Ravikanth Inturi, Isreal kumar Tagaram. Validated novel LC determination of saxagliptin in pure bulk and pharmaceutical dosage forms. International Journal of Pharmaceutical Research and Development, 3(8), 2011, 45-52.
[2]. R. Pravin Cumar, M. Vasudevan, Deecaraman. A Validated RP-HPLC method for simultaneous estimation of metformin and saxagliptin in tablets. Rasayan Journal of Chemistry, 5(2), 2012, 137-141.
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| Paper Type | : | Research Paper |
| Title | : | Genetic Variation in Progeny Performance Traits in Soapnut (Sapindus Mukorossi Gaertn.) of Himachal Pradesh. |
| Country | : | India |
| Authors | : | Vinod Kumar Kairon || H. P. Sankhyan || N.B. Singh || K.R. Sharma |
Abstract:Evaluation in Progeny performance traits was carried out among different twenty four seed sources and in two D.B.H. classes. Progeny performance traits of soapnut seedlings were recorded at intervals, of 3 months and 6 months growth period. All growth performance traits showed significant variation at 3 months and 6 months of intervals among different seed sources.Banjar (S16) seed sources which has larger and heavier seeds showed best performance than under study. Large sized seeds of soapnut exhibited superior growth characteristics than medium and small sized. Banjar seed source is recommended for raising quality planting material and to get improved genetic gain.
Keywords: Soapnut, Sapindus mukorossi, Genetic variation, Progeny performance traits, Nursery evaluation
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| Paper Type | : | Research Paper |
| Title | : | The Dame Blanche's Balm Based on the Hangman's Ointment Behaves as a Occlusive Bandage on Décolletée Skin in man and Woman to Avoid Evaporation and Maintain a Hydrated Epidermis. |
| Country | : | Italy |
| Authors | : | Texia Research || Lorenzo Martini |
Abstract: Ancient beuticians (especially those who lived in the Kings' court) have always sustained that occlusion of epidermis by animal waxes was the unique method to maintain a rich hydration of the neck and décolletée epidermis.Effectively I have attempted to re-create a dermal-cosmetological formula where the hang man's grease (revisited and adjusted to modern concepts) that could perform the attitude to occlude and so to permit the decrease of the evaporation rate of the neck and décolletée skin, a body area that is very delicate since lacks completely of sebaceous glands and is poor of many esters of cholesterol and ceramides.
Keywords: ceramide 1, ceramide 6, Dame Blanche's balm, Ehler Damlos' disease, Pichés evaporimeter.
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