Version-3 (Jan-Feb 2018)
Version 1 Version 2 Version 3 Version 4 Version 5 Version 6
- Citation
- Abstract
- Reference
- Full PDF
- Download Cover Page
| Paper Type | : | Research Paper |
| Title | : | Are The Fruiting And Non-Fruiting Acrocarpous Moss Barbula indica (Hooker) Sprengel in Nigeria Distinct Species? |
| Country | : | Nigeria |
| Authors | : | A. Egunyomi || O.O. Oyesiku || A.O. Bolaji |
 |
: | 10.9790/3008-1301030105  |
Abstract: Barbula indica (Pottiaceae), a dioecious acrocarpous moss had never been found with sporophytes in Nigeria. The occurrence of fruiting B. indica from two populations in the Nigerian forest and derived savanna is reported for the first time. Aspects of the morphological characters of fruiting and non-fruiting plants were compared to ascertain if they are distinct species or not. The leaf and costa length were not significantly different in both types of plants. The ratios mean leaf length : mean leaf width, costa length : leaf length and apical cell size were higher in non-fruiting than in fruiting shoots. However basal and median cell lengths were higher in fruiting than non-fruiting samples. Mean shoot lengths in fruiting plants were 8.8 + 2.946 mm and 9.6 + 2.330 mm in non-fruiting samples. Non-fruiting shoots produced more axillary gemmae than fruiting ones. As all of these vegetative differences are within the morphological range of Barbula indica the fruiting and non-fruiting shoots are not distinct species..
Keywords: Barbula indica moss, fruiting, non-fruiting, Nigeria.
[1]. Aziz, N., Vohra, J.N. (2008). Pottiaceae (Musci) of India. Bishen Singh Mahendrapal Singh Dehra Dun.
[2]. Buck, W.R., Goffinet, B. (2000). Morphology and classification of mosses in Shaw, A.J. and Goffinet, B. (eds.), Bryophyte Biology. Cambridge pp. 71-123.
[3]. Zander, R.H. (1993). Genera of the Pottiaceae: Mosses of harsh environments. Bulletin of the Buffalo Society of Natural Sciences 32: 1-378.
[4]. Kucera, J., Kosenar, J., Werner, O. (2013). Partial generic revision of Barbula (Musci: Pottiaceae): Re-establishment of Hydrogonium and Streblotrichum and the new genus Gymnobarbula. Taxon 62 (1): 21-39.
[5]. Magill, R.E. (1981). Mosses (Sphagnaceae - Grimmiaceae) In Flora of Southern Africa-BRYOPHYTA (Ed. O.A. Leistner). Botanical Research Institute, Dept. of Agriculture, Pretoria. 291pp...
- Citation
- Abstract
- Reference
- Full PDF
| Paper Type | : | Research Paper |
| Title | : | Laxative, Antiinflammatory and Analgesic Effects of Cassia Siamea Lam (Fabaceae) Leaves Aqueous Extract |
| Country | : | Congo |
| Authors | : | Nsonde Ntandou G.F || Etou Ossibi A.W. || Elion Itou R.D.G. || Boumba S.L. || Ouamba J.M. || Abena A. A. |
|
: | 10.9790/3008-1301030615 |
Abstract: Purpose: The objective of this study is to evaluate laxative, anti-inflammatory and analgesic activities of the aqueous extract of C. siamea leaves to contribute to the development of an improved traditional phytomedicine based on this plant. Material and Methods: At doses of 400 and 800 mg / kg administered orally, the aqueous extract of Cassia siamea (Fabaceae) leaves was evaluated in rats. Results: in normal and constipated rats the aqueous extract of the leaves of Cassia siamea significantly decreases, the latency of the first fecal excretion (*** p <0.001) and significantly increased the fecal excretion rate (** * p <0.001), and the total amount of excreted feces (*** p <0.001 and * p <0.05)...............
Keywords: Cassia siamea, leaves, aqueous extract, traditional medicine, laxative, anti-inflammatory, phytochemistry.
[1]. Adiukwu P.C., Kayanja F.I.B., Nambatya G., Adzu B., Twinomujuni S., Twikirize O., Ganiyu A.A., Uwiduhaye E., Agwu E., Tanayen J.K., Nuwagira P. and Buzaare P.( 2013) Anti-Inflammatory and Anti-Pyretic Activity of the Leaf, Root and Saponin Fraction from Vernonia amygdalina. British Journal of Pharmacology and Toxicology 4(2): 33-40.
[2]. Alli Y.R., Adanlawo I.G., Asaolu M.F., and Agbewole O.O. (2011). Effect of aqueous extract of Senna siamea (Cassia leaves) on the liver and kidney of albino rats. Asian Journal of Pharmaceutical and Health Sciences 1: 193-195.
[3]. Ayutthaya W. D. N., Pramyothin P., Piyachaturawat P., Ekataksin W., Chavalittumrong P., Chivapat S., Chaichantipyuth C., (2005). Hepatotoxic effect of barakol in mice. Journal of Traditional Medicines 22: 9-14.
[4]. Bose A., Mondal S., Gupta J.K., Ghosh T., Dash G.K., Si S.,(2007). Analgesic antiinflammatory and antipyretic activities of the ethanolic extract and its fractions of Cleome rutidosperma. Fitoterapia 78: 515-520.
[5]. Croci T., Emonds-Alt X., Le Fur G., Maffrand J.P., Manara L.,(1996). The non-peptide tachykinin NK1- and NK2- receptor antagonists SR 140333 and SR 48968 prevent castor-oil induced diarrhea in rats. Acta Physiol Hung 84:273-274.
- Citation
- Abstract
- Reference
- Full PDF
| Paper Type | : | Research Paper |
| Title | : | Self-Prescription and Therapeutic Attitude Among Students in Baghdad College of Medicine |
| Country | : | Iraq |
| Authors | : | Samara M. Ali || Ameer Talib Abd || Hamza KhalifMazyad || Ammar Issa Amran |
|
: | 10.9790/3008-1301031621 |
Abstract: Self- prescribed drugs comprises a big problem in medicine since drug resistance, cumulative side-effects, drug interactions may harm more than the benefit needed from it. In this study we focused on the population of medical students in Baghdad Medical College and evaluate how much they are aware of what misuse can do.
[1]. L, F. (2017) Analysis and quantification of self-medication patterns of customers in community pharmacies in southern Chile.Pharm. World Sci (2008) 30: 863. doi:10.1007/s11096-008-9241-4 .
[2]. World Health Organization/Drug Action Program (WHO/DAP). Public Education in Rational Drug Use; Report of an Informal Consultation, 23-26 November 1993, Geneva.
[3]. Godeliver A.B. Kagashe1, Bumbuli Msela2: Self medication among patients seen at ophthalmology clinics at four hospitals in dares salaam Tanzania. IOSR Journal of Pharmacy ISSN: 2250-3013, www.iosrphr.org ‖‖ Volume 2 Issue 5 ‖‖ Sep-Oct. 2012 ‖‖ PP.21-25.
[4]. Allibone A, Oakes D, Shannon HS. The health and health care of doctors. J R Coll GenPract.1981;31: 728-734.
[5]. Wachtel TJ, Wilcox VL, Moulton AW, Tammaro D, Stein MD. Physicians' utilization of care. J Gen Intern Med 1995; 10:261-265.
- Citation
- Abstract
- Reference
- Full PDF
| Paper Type | : | Research Paper |
| Title | : | A review of literature on Targeted Drug Delivery Systems for the treatment of oropharyngeal cancer and strategies of targeting cancer |
| Country | : | India |
| Authors | : | Dr. Ayesha Sameera || Dr. Sridhar Reddy Erugula || Dr.Vijay Kumar Nellore || Dr.M.V.S Sudhir || Dr. Annem Sudarshan Kumar || Dr.V.R.Chandrababu Pamidi || Dr. K.T.S.S.Rajajee || Dr.B.Badari Ramakrishna |
|
: | 10.9790/3008-1301031628 |
Abstract: Oral cancer is an aggressive cancer with a high mortality rate. Surgery, chemotherapy, and chemoradiotherapy are the conventional methods that have been used to treat oral cancers but they all come with certain level of compromise. Currently, targeted drug delivery has emerged as a promising method of delivering drugs to targeted site with increased concentration drug to the targeted cancer cells, improved efficacy of treatment which leads to administration of drug in fewer doses and hence reduced side effects. For this purpose, various drug delivery systems have been investigated and formulated. These include liposomes, microspheres, nanoparticles , nanoshells, nanorods, nanocubes, carbon nanotube, nanotubes, nanodiamonds, nanomedicine heat therapy, nanotechnology latest oncolytic agent , quantum dots, curcumin ultrasound mediated delivery and magnetic nanoparticles. The aim of a targeted drug delivery system is to have a protected localize drug interaction with the diseased tissue. The objective of this study is to present a review of targeted drug delivery systems for treatment of oropharyngeal cancers.
Keywords: oral cancer, therapeutics, targeted drug delivery
[1]. Siegel, R. L.; Miller, K. D.; Jemal, A. Cancer statistics, 2016. Ca-Cancer J. Clin. 2016, 66, 7−30.
[2]. Ferlay J, Shin HR, Bray F. et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127:2893–917.
[3]. Hashibe M, Brennan P, Benhamou S. et al. Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: Pooled analysis in the international head and neck cancer epidemiology consortium. Journal Of the National Cancer Institute. 2007;99:777–89.
[4]. D'Souza G, Kreimer AR, Viscidi R. et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med. 2007;356:1944–56.
[5]. Carvalho AL, Nishimoto IN, Califano JA. et al. Trends in incidence and prognosis for head and neck cancer in the United States: a site-specific analysis of the SEER database. Int J Cancer. 2005;114:806–16.
- Citation
- Abstract
- Reference
- Full PDF
| Paper Type | : | Research Paper |
| Title | : | Histological study of the embryogenesis of metencephalon in pre-implantation of albino rat's embryos after maternal treated with silver nanoparticles |
| Country | : | Iraq |
| Authors | : | Esraa H. Ali || Lina A. Salih |
|
: | 10.9790/3008-1301032934 |
Abstract: Cerebellum is the most important and critical part of the central nervous system, cerebellum is very sensitive to the abnormal changes during the embryological development in its histological structure, the exposure to any infection during embryogenesis produce abnormalities in the cerebellum and behavioral of offspring. In this study we tried to study the ontogenesis of the cerebellum in the embryos of the albino rats and detection the effect of the AgNPs on the ontogenesis of the rat cerebellum after exposure of AgNPs during pregnancy. we used 60 female pregnant rats divided in to three group, each contain 20 female, (G1) treated with 2mg/kg /day suspension of silver nanoparticles (Ag NPs) (G2) treated with 20mg/kg/day AgNPs from first day of pregnancy until delivery at.............
Key words: embryogenesis, metencephalon, rats, silver, nanoparticles.
[1]. Rivero, P. Urrutia, A. Goicoechea, J. and Arregui, F. J. Nanomaterials for functional textiles and fibers. Nanoscale Res Lett. (2015)10:501.
[2]. Prabhu, S. and Poulose, E. K. Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects. Int. Nano. Lett. 2(1) (2012):32.
[3]. Ribeiro, F.; GallegoUrrea, J. A.; Jurkschat, K. ; Crossley,A.; Hassellov, M.; Taylor,C.; Soares, A.M. and Loureiro,S. Silver nanoparticles and silver nitrate induce high toxicityto Pseudo kirchneriella subcapitata, Daphnia magna and Danio rerio. Sci. Total Environ.466–467 (2013) 232–241.
[4]. Gomes, M.G., Dreier,J., Brewer ,J., Martins , S., Brandl ,M. and Sarmento, B. A new approach for a blood-brain barrier model based on phospholipid vesicles: Membrane development and siRNA-loaded nanoparticles permeability. J. of Membrane Science. 503(2016):8–15..
[5]. Bhaskar, S. F.; Tian, T.; Stoeger, W.; Kreyling, J. M. de la Fuente, V. Grazu, P.; Borm, G.; Estrada, V.; Ntziachristos, D. and Razansky. Multifunctional Nanocarriers for di- agnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging, Part Fibre Toxicol. 7(2010): 3.
- Citation
- Abstract
- Reference
- Full PDF
| Paper Type | : | Research Paper |
| Title | : | Les Décollements De Rétine Post Contusifs: Étude Rétrospective A Propos De 62 Cas Contusive Retinal Detachment: A Retrospective Review Of 62 Patients |
| Country | : | Maroc |
| Authors | : | Samia Nassik || Aouatef Masmoudi || Salssabile Nafiz || Hajar Salek || Souhaila Karmoun || Amina Berraho |
|
: | 10.9790/3008-1301033536 |
Abstract: Les décollements de rétine sont une cause majeure de cécité dans les pays développés et en voie de développement. Et malgré l'essor de techniques chirurgicales pour améliorer les résultats anatomiques et fonctionnels, les yeux subissant un traumatisme oculaire sévère ont un pronostic réservé, lié notamment au développement d'un décollement de rétine. Notre étude porte sur 62 patients qui ont présenté un décollement de rétine dans les suites d'une contusion oculairepris en charge à l'hôpital des spécialités de Rabat entre 2005 et 2015. Nous en avons étudié les caractéristiques épidémiologiques, cliniques et thérapeutiques, et nous avons déterminé grâce à une analyse statistique que les décollements post contusif sont l'apanage du sujet jeune, les désinsertion à l'ora serrata étaient les lésions les plus fréquentes ,le succès anatomique a été noté dans plus de 90% des cas,il convient de renforcer l'information et la prévention, de réaliser un examen précoce et régulier de la périphérie rétinienne après tout traumatisme oculaire...........
Keywords: Retinal detachment, ocular blunt trauma
[1]. V. Shah, N. Hall, MJ. Goldacre.Retinal detachment in England: database studies of trends over time and geographical variation, Br J Ophthalmo,2015, 99: 639-643.
[2]. P. Girard, C. Boscher,F. Navarro, A. Forest. Les décollements de rétine par déchirures géantes, J Fr Ophtalmol,1984 , 7 : 205-209.
[3]. A. Ambresin, T.J. Wolfensberger, E.H. Bovey. Management of giant retinal tears with vitrectomy, internal tamponade, and peripheral 360 degrees retinal photocoagulation, Retina, 2003, 23 : 622-628.
[4]. Y.K. Ghosh, S. Banerjee, V. Savant, V. Kotamarthi, M.T. Benson, R.A. Scott, and al. Surgical treatment and outcome of patients with giant retinal tears Eye, 2004 ; 18 : 996-1000.
- Citation
- Abstract
- Reference
- Full PDF
| Paper Type | : | Research Paper |
| Title | : | Résultats DeLa Trabeculoplastie Sélective sur La Baisse Pressionnelle Dans Le GPAOResults of Selective Trabeculoplasty on Pressure Reduction in POAG |
| Country | : | Maroc |
| Authors | : | Samia Nassik Salssabile Nafizy || Aouatef Masmoudi || Hajar Salek || Souhaila Karmoun || Amina Berraho |
|
: | 10.9790/3008-1301033738 |
Abstract: Pour vérifier les résultats tonométriques de SLT dans le traitement du glaucome primaire à angle ouvert une étude rétrospective a été réalisée dans notre unité glaucome. 116yeux de 58 patients ont bénéficié de la procédure laser SLT. Le but du travail est d'étudier l'effet du Laser SLT sur la PIO et de comparer les résultats en fonction du mode de traitement : SLT 1ère intention , SLT 2ème et 3ème intention.Ainsi on a constater que le groupe de bon répondeurs était principalement constitué de patients non traités ou sous monothérapie soit une réduction de la pression intra oculaire entre 20% et 35%. Notre expérience a prouvé son efficacité comme traitement de 1ere intention dans les glaucomes débutant avec des chiffres tensionnels peu élevé seul ou en association avec d'autres thérapeutiques hypotonisantes, ce qui concorde avec les études publiées...........
Keywords:Glaucoma , selective laser trabeculoplasty
[1]. JB. Wise, SL. Witter. Argon laser therapy for open angle glaucoma : a pilot study,Arch ophthalmol, 1979 ; 97 : 319-22.
[2]. UP. Best, h. Domack, V. Schmidt. Long term results after selective laser trabeculoplasty: a clinical study on 269 eyes. Klin Monatsbl Augenheilk, 2005 ; 222 : 326-31.
[3]. MA. Latina, SA. Sibayan, DH et al. Shin. Q switcher 532-nm Nd, YAG laser trabeculoplasy: a multi center, pilot, clinical study. Ophthalmology, 1998 ; 105 : 2082-8.
[4]. LF. Jndra. SLT as primary treatment. Ophthalmol Management, 2004 ; 8 : 77-8.
[5]. S. Melamed, GJ. Ben Simon, H.Levkovitch-Verbin. Selective laser trabeculoplasty as primary treatment for open angle glaucoma : a prospective, non randomised pilot study. Arch Ophthalmo, 2003 ; 121 : 957-60. [6]. BA. Francis, T. Ianchulev, JK. Schofield, DS. Minckler. Selective laser trabeculoplasty as replaczement for médical therapy in open-angle glaucoma. Am j ophthalmol, 2005 ; 140 : 524-5..
- Citation
- Abstract
- Reference
- Full PDF
| Paper Type | : | Research Paper |
| Title | : | Effects of Ampiclox andAmoxicillin on thePharmacokinetics of Metformin in Type II Diabetic Patients |
| Country | : | Nigeria |
| Authors | : | Garba, M.A. || Bakare-Odunola, M.T. || Garba,M. || Yakasai, A.I. || Musa, A. || Haruna, A |
|
: | 10.9790/3008-1301033944 |
Abstract: Infection is common in diabetes and in the course of treatment,ampiclox and amoxicillin may be co-administered with metformin. The study was designed to evaluate the effects of co-administration of ampiclox and amoxicillin on the pharmacokinetics of metformin in type II diabetic patients. Twelve patients with age ranging from 25 – 55 years, weight 50 – 70 kg and height 1.5 – 1.75 m participated in the study. The study was divided into two phases with a washout period of seven days between the phases. In phase one, metformin alone was administered to all the subjects with 150 ml of water after an overnight fasting. In phase two, the subjects were divided into two groups..........
Keywords: Ampiclox,Amoxicillin,Diabetes, HPLC, Metformin
[1]. ADA (American Diabetes Association) (2013).Nutritional recommendations and principles for individual with diabetes Mellilus.Diabetes care.10:126 – 132.
[2]. Bhavesh D,.Chetan, G Bhat1 K. M.andShivprakash (2007). "Estimation and pharmacokinetics of metformin in human volunteers".Indian Journal.Pharm. Educ. Res. 41(2).
[3]. Bakare-Odunola, M.T., Garba, M., Enemali, S.I., Okeniyi, S.O. and Gebi, J. (2001).The influence of ampicillin/cloxacillin on the pharmacokinetics of chlorpropamide in Type 2 diabetic Patients.West African Journal of pharmacology. Drug Research 17: (1and 2) 74-76.
[4]. Burger A.S.V and Mitchell J.F (eds).1985.General Pharmacology, kinetics and sulphonylureas.In: Gaddum pharmacology. Oxford University Press, London.PP17, 162-201.
[5]. Charles, B.G., Precechagoom, Y., Lee, T.C., Sheer, P.A., Flennady, V.J. and Debuse, N.(2009).Population pharmacokinetic of intravenous amoxicillin in very low birth weight infants.Journal of Pharmaceutical Sciences.86(22):1288-12292...
- Citation
- Abstract
- Reference
- Full PDF
| Paper Type | : | Research Paper |
| Title | : | Analyzing the Impact of Statins Use in Type-2 Diabetes Mellitus Patients |
| Country | : | India |
| Authors | : | Dr .C.Vani || B. Laxmi Narayana || P. Prashanthi || B. Karthik |
|
: | 10.9790/3008-1301034553 |
Abstract: Aim: To analyze the impact of statins use in type-2 diabetes patients. Objective: To improve the quality of life and to decrease the risk associated with cardiovascular events, to increase the patient compliance towards statin therapy and to increase the awareness among patients about statin therapy and lifestyle modifications. To identify the cost of different statins containing drug brands. Methodology: A prospective observational study was conducted in secondary care centers and data was collected from medical case records,116 diabetic type 2 patients under treatment with stains were interviewed twice and their demographic data(age, gender, education) , statin information ,their serum lipid profile were recorded. In between three months after the initial visits, patients were assessed using questionnaires and also assessed cholesterol ratio. The Framingham Risk Score is a gender-specific algorithm used to estimate the 10-year cardiovascular risk of an individual..........
Keywords: Adherence, lipid profile, quality of life, Statin, Type-2 diabetes
[1]. Miettinen TA (March 1982). "Diurnal variation of cholesterol precursors squalene and methyl sterols in human plasma lipoproteins". Journal of Lipid Research. 23 (3): 466–73.
[2]. Cholesterol Treatment Trialists‟ (CTT) Collaboration. Baigent C, Blackwell L, Emberson J, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet. 2010;376(9753):1670–1681.
[3]. Saito Y, Yoshida S, Nakaya N, Hata Y, Goto Y (Jul–Aug 1991). "Comparison between morning and evening doses of simvastatin in hyperlipidemic subjects. A double-blind comparative study". Arterioscler Thromb. 11 (4): 816–26. doi:10.1161/01.ATV.11.4.816.
[4]. Wallace A, Chinn D, Rubin G (4 October 2003). "Taking simvastatin in the morning compared with in the evening: randomised controlled trial". British Medical Journal. 327 (7418): 788. doi:10.1136/bmj.327.7418.788.
[5]. Reiner Z, Catapano AL, De Backer G, Graham I, Taskinen MR, Wiklund O, et al. ESC/EAS guidelines for the management of dyslipidaemias. Eur Heart J. 2011;32:1769–1818. doi: 10.1093/eurheartj/ehr158
- Citation
- Abstract
- Reference
- Full PDF
| Paper Type | : | Research Paper |
| Title | : | Novel Proniosomes as Drug Delivery System for Transdermal Application of Itraconazole: Development, Characterization, Clinical and Bioavailability StudY |
| Country | : | Egypt |
| Authors | : | Ahmed M. Samy || Afaf A. Ramadan || Amal S.M. Abu El-Enin || Yasmin I. M. Mortagi || Mohammad M. Abd-Alhaseeb |
|
: | 10.9790/3008-1301035471 |
Abstract: Objectives: The objective of the present study was to incorporateItraconazole (ITC)proniosomes in different gel bases in order to develop ITC proniosomal gel for tansdermalapplication and alsoto achieve high drug plasma levels with enhanced bioavailability. Methods: ITCproniosomes optimized formula was prepared by slurry method and the prepared vesicles were evaluated for their entrapment efficiency (EE%),in-vitroITC release, zeta potential and vesicle size. The prepared optimized formula was then incorporated in different gelling agents as xanthan gum, methyl cellulose (MC), hydroxy propyl methyl cellulose (HPMC) and Carbopol 934. The effect of type and concentration of the employed gel bases on homogeneity, spreadability, extrudability, pH, drug content,the permeation study and viscosity measurement, was studied in all prepared gels. Effect of storage was studied forthe best four formulae at three different temperature for six months. Also,the best formula (G3 containing 5% MC) was used to study the antifungal activity, in vivo therapeutic efficacyand also pharmacokinetic parametersin the ratswhich then compared with commercially available formulations (Sporanox®) capsule and solution..........
Keywords: Itraconazole (ITC); entrapment efficiency (EE%); pharmacokinetics; bioavailability
[1]. Hay R.J., Dupont B. and Graybill J.R., Review Infectious Disease, 9 (1): 1-3, (1987).
[2]. Tang J., Wei H., Liu H., Ji H., DongD., Zhu D., and Wu L., Pharmacokinetics and biodistribution of Itraconazole in rats and mice following intravenous administration in a novel liposome formulation, Drug Deliv., 17 (4): 223-230, (2010).
[3]. Jamakandi V.G., Ghosh B., Desai B.G., and Khanam J., Recent trends in transdermal cardiovascular therapy, Ind. J. Pharm. Sci., 68: 556-561, (2006).
[4]. Schreier H., and Bouwastra J., Liposomes and niosomes as topical drug carriers: dermal and transdermal drug delivery, J. Control Release, 30: 1-15, (1994).
[5]. Thomas L., and Viswanad V., Formulation and optimization of Clotrimazole-loaded proniosomal gel using 32 factorial design, J. Pharm. Sci., 80: 731-748, (2012).
- Citation
- Abstract
- Reference
- Full PDF
| Paper Type | : | Research Paper |
| Title | : | SDS-PAGE Band Patterns of Partially Purified Peroxidase Isozymes Extracted from Telfairia Mosaic Virus (TeMV) Infected and HealthyP lant Leaves of Telfairia occide ntalis (Hook F.) |
| Country | : | Nigeria |
| Authors | : | Mofunanya, A. A. J || Egbe, A. O. |
|
: | 10.9790/3008-1301037277 |
Abstract: This study was carried out to separate Telfairia occidentalis peroxidase isozymes extracted from leaves of Telfairia mosaic virus (TeMV) infected and healthy plants by SDS-PAGE and compare their banding patterns for difference. Telfairia occidentalis plants were grown under green house condition and arranged in a completely randomized design prior to inoculation. Randomly selected plants were inoculated with TeMV. Peroxidase isozymes extracted from healthy and infected plants were separated by SDS-PAGE, using 12.5% resolving gel buffered at pH 8.8 and 5% stacking gel in tris glycine buffered at pH 6.8. The isozymes profiles of healthy and infected plants were qualitatively analyzed for presence or absence of bands and quantitatively using Rf values. Analysis of the peroxidase.........
Keywords: Band patterns, Peroxidase isozyme, Telfairia mosaic virus (TeMV), Telfairia occidentalis
[1]. S. A. Shoyinka and G. Thottappily, Occurrence of Telfairia mosaic virus in Nigeria. African Crop Science Journal.1998, 6(1): 69-78.
[2]. W. B. Akanbi, T. A. Adebayo, O. A. Togun, A. S. Adeyeye and O. A. Olaniran, The of compost extract as foiar spray nutrient source and botanical insecticide in Telfairia occidentalis. World Journal of Agriculture. 2007, 3(5): 642-652.
[3]. A. A. J. Mofunanya, D. N. Omokaro,A. T. Owolabi and N. E. Ine-Ibehe, Effect of Telfairia mosaic virus (TeMV) infection on the proximate, mineral and anti-nutritive contents of Telfairia occidentalis Hook (Fluted pumpkin). Nigerian Journal of Botany. 2008, 12(2): 304-315.
[4]. A. O. Fasuyi and V. A. Aletor, Varietal composition and functional properties of cassava (Manihot esculenta Crantz) leaf and leaf protein concentrates. Pakistan Journal of Nutrition. 2005, 4(1): 43-49.
[5]. A. A. J. Mofunanya, D. N. Omokaro, A. T. Owolabi, P. J. Nya, M. M. Etukudo and S. E. Osim, Determination of the effect of Telfairia mosaic virus on vitamins and amino acids profile of two ecotypes of Telfairia occidentalis (fluted pumpkin). Interantional Journal of Natural and Applied Sciences (IJNAS). 2009, 4(1&2): 1-10.
- Citation
- Abstract
- Reference
- Full PDF
| Paper Type | : | Research Paper |
| Title | : | Method Development and Validation of Mirabegron in Bulk Drug and Pharmaceutical Dosage Form |
| Country | : | India |
| Authors | : | Jyothsna M || Dr. RayeesAhmedMd || Dr. Ramesh T || Syed Anwar || Kranthi Raju P |
|
: | 10.9790/3008-1301037883 |
Abstract: A new, simple, precise, accurate and reproducible Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method for Simultaneous estimation of bulk and pharmaceutical formulations. Separation of Mirabegron was successfully achieve THERMO, C18, 250X4.6mm, 5μm or equivalent in an isocratic mode utilizing 0.1M KH2PO4 : Methanol (60:40) at a flow rate of 1.0ml/min and eluate was monitored at 248nm, with a retention time of 3.684 minutes for Mirabegron. The method was validated and the response was found to be linear in the drug concentration range of 50μg/ml to150 μg/ml for Mirabegron. The values of the correlation coefficient were found to 0.999for Mirabegron. The Limit of Detection(LOD) and Limit of Quantification (LOQ) for Mirabegron were found to be 0.149 and 0.498 respectively. This method was found to be good percentage recovery were found to.........
Keywords: Mirabegron, High performance liquid chromatography, Validation
[1]. Takasu T, Ukai M, Sato S, Matsui T, Nagase I, Maruyama T, Sasamata M, Miyata K, Uchida H, Yamaguchi O, Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl) amino] ethyl} acetanilide (YM178), a novel selective beta3-adrenoceptor Agonist, on bladder fun. J Pharmacol Exp Ther2007; 321(2), 642-7.
[2]. Yamaguchi O, Chapple CR. Beta3-adrenoceptors in urinary bladder. Neurourol Urodyn. 2007; 26(6):752-6
[3]. Raymond van Teijingen, John Meijer, Shin Takusagawa,Marcel van geldren,Cas van den Beld,Takashi usui.Development and validation of LC-MS/MS methods for the determination of Mirabegron and its metabolites in human plasma and their application to a clinical pharmacokinetic study. J Chromatography B, 2012; 102-111.
[4]. Available from www.drugbank.ca/drugs Mirabegron basic information: Physical and chemical properities.
[5]. Available from www.drugbank.ca/drugs Mirabegron Pharmacokinetics.