Abstract: The interaction between Schiff base of Sulfathiazole and (β-CD) was investigated. The Inclusion complex was prepared followed freeze drying method and the mode of interaction was characterized by IR , 1HNMR and DSC analysis , the IR bands and 1HNMR signal undergo significant shifts or masked by host bands. The XRD patterns show the decrease of crystinality of the complex. The Phase solubility study was investigated following Higuchi and Connors method and the result indicated the enhancing the aqueous solubility by ~6 folds and the value of solubility constant (1131 M-1) indicate the formation of 1:1 Schiff : (β-CD) molar ratio.
Key Words: Sulfathiazole , Schiff base , Inclusion complex , Phase solubility
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