Abstract: Gas chromatophic FID analysis of leaves of Laportea aestuans was conducted and showed the presence of polyphenols, flavonoids, terpenes, carotenoids and saponins. The effects of Laportea (Linn) on alloxan induced diabetes in rats were also evaluated using glucose and lipid profiles. Animals weighing (160 – 200g) were divided into 3 groups of 21 animals each; Group 1 (normal control), Group 2 (diabetes control) and Group 3 (test). Diabetes was induced in albino rats by intraperitoneal injection of alloxan in group 2 and 3 respectively. Animals in group 1 and 2 received normal rat feed while animals in group 3 were fed with Laportea aestuans leaves for a period of 28 days. Animals were sacrificed on day 28. Glucose, glycated hemoglobin and lipid profile were estimated. Laportea aestuans leaves elicited significant (P<0.05) reduction of blood glucose and lipid profile parameters except high density lipoprotein cholesterol (HDL-C) which significantly increased. L. aestuans offer promise as antidiabetic and antihyperlipidemia.
Key words: Gas – chromatography – FID, Laportea aestuans, diabetes, hypercholesterolemia.
[1]. U.A. Essiet, N.I. Edet, and D.N. Bala, "Phytochemical and physiochemical analysis of the leaves of Laportea aestuans (Linn) Chew and Laportea aestuans (Schumach) Chew (male and female)", Asian Journal of Plant Science and Research, vol. 1 no. 2, pp. 35 – 42, 2011.
[2]. I.O. Oyewole, and P.F. Akingbala, "Phytochemical analysis and hypolipidemic properties of Jatropha tanjorensis leaf Extract", European Journal of Medicinal Plants, vol. 1, no. 4, pp. 180-185, 2011.
[3]. R.E. Olson, "Discovery of the lipoproteins, their roles in fat transport and their significance as risk factors", J. Nutr., vol. 128, no. 2, pp. 439 – 443, 1998.
[4]. P. Barter, A.M. Larosa, J.C. Maroni, J. Szareke, M.S.M. Grundy, J.P. Kastelein, and V. Bittner, "HDL cholesterol and cardiovascular events", New Engl. J. Med., vol. 357, no 13, pp. 1301 – 1309, 2007.
[5]. B.N. Okigbo, "Neglected plants of horticultural and nutritional importance in traditional farming systems of tropical Africa". Acta Horticulturae vol. 53, pp. 131-150, 1977.