Abstract:Objective: Vitamin C is a vital antioxidant that may antagonize deleterious effects of smoking. The aim of this study was to evaluate the effects of administration of nicotine alone for three weeks or combined with vitamin C on the antioxidant defense status, functional, histopathological changes, and immunohistochemical demonstration of proliferating cell nuclear antigen (PCNA) in rat liver and kidney tissues. Methods: Animals were divided into four groups; (C) saline-treated, (VC) vitamin C-treated, (NIC) nicotine-treated, all were for 3 weeks, and (NIC+VC) is given vitamin C for 3 days prior, with nicotine injection and 2 days thereafter.
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